ID:S100B_HUMAN DESCRIPTION: RecName: Full=Protein S100-B; AltName: Full=S-100 protein beta chain; AltName: Full=S-100 protein subunit beta; AltName: Full=S100 calcium-binding protein B; FUNCTION: Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. SUBUNIT: Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. The S100B dimer binds two molecules of STK38. Interacts with AGER (By similarity). The S100B dimer interacts with two molecules of CAPZA1. Interacts with ATAD3A; this interaction probably occurs in the cytosol prior to ATAD3A mitochondrial targeting. Interacts with CACYBP in a calcium- dependent manner (By similarity). INTERACTION: Self; NbExp=4; IntAct=EBI-458391, EBI-458391; P23297:S100A1; NbExp=5; IntAct=EBI-458391, EBI-743686; P31949:S100A11; NbExp=5; IntAct=EBI-458391, EBI-701862; P06703:S100A6; NbExp=5; IntAct=EBI-458391, EBI-352877; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues. MISCELLANEOUS: In addition to metal-ion binding, this protein is involved with the regulation of protein phosphorylation in brain tissue. SIMILARITY: Belongs to the S-101 family. SIMILARITY: Contains 2 EF-hand domains. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/S100BID42195ch21q22.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P04271
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
CS301701 - Sequence 2 from Patent WO2006000719. CS301702 - Sequence 3 from Patent WO2006000719. JD144113 - Sequence 125137 from Patent EP1572962. JD156342 - Sequence 137366 from Patent EP1572962. JD482303 - Sequence 463327 from Patent EP1572962. JD316280 - Sequence 297304 from Patent EP1572962. BC001766 - Homo sapiens S100 calcium binding protein B, mRNA (cDNA clone MGC:1323 IMAGE:3543825), complete cds. FW339990 - Screening. JD307532 - Sequence 288556 from Patent EP1572962. JD444882 - Sequence 425906 from Patent EP1572962. JD362184 - Sequence 343208 from Patent EP1572962. DQ892491 - Synthetic construct clone IMAGE:100005121; FLH186785.01X; RZPDo839A0672D S100 calcium binding protein, beta (neural) (S100B) gene, encodes complete protein. EU176695 - Synthetic construct Homo sapiens clone IMAGE:100011660; FLH264093.01L; RZPDo839G05257D S100 calcium binding protein B (S100B) gene, encodes complete protein. CR542123 - Homo sapiens full open reading frame cDNA clone RZPDo834C0623D for gene S100B, S100 calcium binding protein, beta (neural); complete cds, incl. stopcodon. KJ897514 - Synthetic construct Homo sapiens clone ccsbBroadEn_06908 S100B gene, encodes complete protein. AB464700 - Synthetic construct DNA, clone: pF1KB8857, Homo sapiens S100B gene for S100 calcium binding protein B, without stop codon, in Flexi system. KU178319 - Homo sapiens S100 calcium binding protein B isoform 1 (S100B) mRNA, partial cds. KU178320 - Homo sapiens S100 calcium binding protein B isoform 2 (S100B) mRNA, complete cds, alternatively spliced. BC041935 - Homo sapiens S100 calcium binding protein, beta (neural), mRNA (cDNA clone IMAGE:5300855).
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P04271 (Reactome details) participates in the following event(s):
R-HSA-879377 The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B R-HSA-879411 Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor R-HSA-879362 AGER binds ERK1/2 R-NUL-997411 AGER binds rat ERK1/2 R-HSA-1251985 Nuclear signaling by ERBB4 R-HSA-879415 Advanced glycosylation endproduct receptor signaling R-HSA-1236394 Signaling by ERBB4 R-HSA-168249 Innate Immune System R-HSA-9006934 Signaling by Receptor Tyrosine Kinases R-HSA-168256 Immune System R-HSA-162582 Signal Transduction
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
