ID:SASH1_HUMAN DESCRIPTION: RecName: Full=SAM and SH3 domain-containing protein 1; AltName: Full=Proline-glutamate repeat-containing protein; FUNCTION: May have a role in a signaling pathway. Could act as a tumor suppressor. TISSUE SPECIFICITY: Expressed ubiquitously, with highest levels in lung, placenta, spleen and thymus. Down-regulated in the majority (74%) of breast tumors in comparison with corresponding normal breast epithelial tissues. SIMILARITY: Contains 2 SAM (sterile alpha motif) domains. SIMILARITY: Contains 1 SH3 domain. SEQUENCE CAUTION: Sequence=BAA34510.1; Type=Erroneous initiation; Sequence=BAB14909.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O94885
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0008022 protein C-terminus binding GO:0019901 protein kinase binding GO:0031435 mitogen-activated protein kinase kinase kinase binding GO:0032947 protein complex scaffold
Biological Process: GO:0000209 protein polyubiquitination GO:0010595 positive regulation of endothelial cell migration GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway GO:0043507 positive regulation of JUN kinase activity GO:0045766 positive regulation of angiogenesis GO:1900044 regulation of protein K63-linked ubiquitination GO:1900745 positive regulation of p38MAPK cascade GO:1901224 positive regulation of NIK/NF-kappaB signaling GO:1902498 regulation of protein autoubiquitination
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
