ID:SCAR5_HUMAN DESCRIPTION: RecName: Full=Scavenger receptor class A member 5; AltName: Full=Scavenger receptor hlg; FUNCTION: Ferritin receptor that mediates non-transferrin- dependent delivery of iron. Mediates cellular uptake of ferritin- bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type- specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1) (By similarity). SUBUNIT: Homotrimer (By similarity). SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein (By similarity). SIMILARITY: Belongs to the SCARA5 family. SIMILARITY: Contains 1 collagen-like domain. SIMILARITY: Contains 1 SRCR domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 140718 - Mediator hinge subcomplex-like 56487 - SRCR-like
ModBase Predicted Comparative 3D Structure on Q6ZMJ2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
