Human Gene SCD (ENST00000370355.3_4) from GENCODE V47lift37
  Description: stearoyl-CoA desaturase (from RefSeq NM_005063.5)
Gencode Transcript: ENST00000370355.3_4
Gencode Gene: ENSG00000099194.6_7
Transcript (Including UTRs)
   Position: hg19 chr10:102,106,990-102,124,583 Size: 17,594 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr10:102,107,262-102,120,690 Size: 13,429 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:102,106,990-102,124,583)mRNA (may differ from genome)Protein (359 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ACOD_HUMAN
DESCRIPTION: RecName: Full=Acyl-CoA desaturase; EC=1.14.19.1; AltName: Full=Delta(9)-desaturase; Short=Delta-9 desaturase; AltName: Full=Fatty acid desaturase; AltName: Full=Stearoyl-CoA desaturase;
FUNCTION: Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA.
CATALYTIC ACTIVITY: Stearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O.
COFACTOR: Iron.
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable).
DOMAIN: The histidine box domains may contain the active site and/or be involved in metal ion binding.
SIMILARITY: Belongs to the fatty acid desaturase family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SCD
Diseases sorted by gene-association score: reye syndrome (6), obesity (2), diabetes mellitus, noninsulin-dependent (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 533.98 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 3555.39 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -109.70272-0.403 Picture PostScript Text
3' UTR -1185.503893-0.305 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005804 - Fatty_acid_desaturase-1
IPR001522 - Fatty_acid_desaturase-1_C
IPR015876 - Fatty_acid_desaturase-1_core

ModBase Predicted Comparative 3D Structure on O00767
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGD  WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004768 stearoyl-CoA 9-desaturase activity
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
GO:0046872 metal ion binding

Biological Process:
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006636 unsaturated fatty acid biosynthetic process
GO:0045540 regulation of cholesterol biosynthetic process
GO:0046949 fatty-acyl-CoA biosynthetic process
GO:0055114 oxidation-reduction process
GO:1903966 monounsaturated fatty acid biosynthetic process

Cellular Component:
GO:0005730 nucleolus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AB032261 - Homo sapiens Scd mRNA for stearoyl-CoA desaturase, complete cds.
BC062303 - Homo sapiens stearoyl-CoA desaturase (delta-9-desaturase), mRNA (cDNA clone MGC:71288 IMAGE:6586153), complete cds.
AK312312 - Homo sapiens cDNA, FLJ92619, highly similar to Homo sapiens stearoyl-CoA desaturase (delta-9-desaturase) (SCD), mRNA.
AB208982 - Homo sapiens mRNA for stearoyl-CoA desaturase variant protein.
LF345707 - JP 2014500723-A/153210: Polycomb-Associated Non-Coding RNAs.
AF097514 - Homo sapiens stearoyl-CoA desaturase (SCD) mRNA, complete cds.
JD469937 - Sequence 450961 from Patent EP1572962.
AK222862 - Homo sapiens mRNA for stearoyl-CoA desaturase variant, clone: HEP13102.
Y13647 - Homo sapiens mRNA for stearoyl-CoA desaturase.
JD487006 - Sequence 468030 from Patent EP1572962.
BC005807 - Homo sapiens stearoyl-CoA desaturase (delta-9-desaturase), mRNA (cDNA clone IMAGE:3844850), complete cds.
JD534022 - Sequence 515046 from Patent EP1572962.
LF345708 - JP 2014500723-A/153211: Polycomb-Associated Non-Coding RNAs.
AB529038 - Synthetic construct DNA, clone: pF1KB3456, Homo sapiens SCD gene for stearoyl-CoA desaturase, without stop codon, in Flexi system.
KJ897520 - Synthetic construct Homo sapiens clone ccsbBroadEn_06914 SCD gene, encodes complete protein.
S70284 - stearoyl-CoA desaturase [human, adipose tissue, mRNA Partial, 712 nt].
LF345710 - JP 2014500723-A/153213: Polycomb-Associated Non-Coding RNAs.
AF116616 - Homo sapiens PRO0998 mRNA, complete cds.
JD239446 - Sequence 220470 from Patent EP1572962.
JD364234 - Sequence 345258 from Patent EP1572962.
LF345711 - JP 2014500723-A/153214: Polycomb-Associated Non-Coding RNAs.
LF345712 - JP 2014500723-A/153215: Polycomb-Associated Non-Coding RNAs.
JD355925 - Sequence 336949 from Patent EP1572962.
LF345716 - JP 2014500723-A/153219: Polycomb-Associated Non-Coding RNAs.
LF345718 - JP 2014500723-A/153221: Polycomb-Associated Non-Coding RNAs.
LF345719 - JP 2014500723-A/153222: Polycomb-Associated Non-Coding RNAs.
LF345722 - JP 2014500723-A/153225: Polycomb-Associated Non-Coding RNAs.
LF345726 - JP 2014500723-A/153229: Polycomb-Associated Non-Coding RNAs.
LF345759 - JP 2014500723-A/153262: Polycomb-Associated Non-Coding RNAs.
LF345729 - JP 2014500723-A/153232: Polycomb-Associated Non-Coding RNAs.
JD332950 - Sequence 313974 from Patent EP1572962.
JD301735 - Sequence 282759 from Patent EP1572962.
LF345731 - JP 2014500723-A/153234: Polycomb-Associated Non-Coding RNAs.
JD261523 - Sequence 242547 from Patent EP1572962.
JD327490 - Sequence 308514 from Patent EP1572962.
LF345733 - JP 2014500723-A/153236: Polycomb-Associated Non-Coding RNAs.
JD145551 - Sequence 126575 from Patent EP1572962.
JD048350 - Sequence 29374 from Patent EP1572962.
LF345735 - JP 2014500723-A/153238: Polycomb-Associated Non-Coding RNAs.
JD268257 - Sequence 249281 from Patent EP1572962.
JD183408 - Sequence 164432 from Patent EP1572962.
JD503943 - Sequence 484967 from Patent EP1572962.
JD314756 - Sequence 295780 from Patent EP1572962.
LF345736 - JP 2014500723-A/153239: Polycomb-Associated Non-Coding RNAs.
JD410283 - Sequence 391307 from Patent EP1572962.
JD526129 - Sequence 507153 from Patent EP1572962.
JD088296 - Sequence 69320 from Patent EP1572962.
JD201002 - Sequence 182026 from Patent EP1572962.
AF109362 - Homo sapiens MSTP008 mRNA, complete cds.
LF345737 - JP 2014500723-A/153240: Polycomb-Associated Non-Coding RNAs.
JD344961 - Sequence 325985 from Patent EP1572962.
LF345738 - JP 2014500723-A/153241: Polycomb-Associated Non-Coding RNAs.
JD187544 - Sequence 168568 from Patent EP1572962.
JD491344 - Sequence 472368 from Patent EP1572962.
JD377528 - Sequence 358552 from Patent EP1572962.
JD338838 - Sequence 319862 from Patent EP1572962.
JD463943 - Sequence 444967 from Patent EP1572962.
JD356728 - Sequence 337752 from Patent EP1572962.
JD348436 - Sequence 329460 from Patent EP1572962.
JD262748 - Sequence 243772 from Patent EP1572962.
LF345739 - JP 2014500723-A/153242: Polycomb-Associated Non-Coding RNAs.
JD442467 - Sequence 423491 from Patent EP1572962.
LF345740 - JP 2014500723-A/153243: Polycomb-Associated Non-Coding RNAs.
LF345742 - JP 2014500723-A/153245: Polycomb-Associated Non-Coding RNAs.
JD555094 - Sequence 536118 from Patent EP1572962.
JD244582 - Sequence 225606 from Patent EP1572962.
JD398842 - Sequence 379866 from Patent EP1572962.
JD219450 - Sequence 200474 from Patent EP1572962.
LF345744 - JP 2014500723-A/153247: Polycomb-Associated Non-Coding RNAs.
JD040472 - Sequence 21496 from Patent EP1572962.
JD314296 - Sequence 295320 from Patent EP1572962.
JD328463 - Sequence 309487 from Patent EP1572962.
JD167683 - Sequence 148707 from Patent EP1572962.
JD525562 - Sequence 506586 from Patent EP1572962.
JD377538 - Sequence 358562 from Patent EP1572962.
JD455778 - Sequence 436802 from Patent EP1572962.
JD515747 - Sequence 496771 from Patent EP1572962.
JD492794 - Sequence 473818 from Patent EP1572962.
JD515891 - Sequence 496915 from Patent EP1572962.
JD081509 - Sequence 62533 from Patent EP1572962.
JD271879 - Sequence 252903 from Patent EP1572962.
JD465179 - Sequence 446203 from Patent EP1572962.
LF345745 - JP 2014500723-A/153248: Polycomb-Associated Non-Coding RNAs.
LF345746 - JP 2014500723-A/153249: Polycomb-Associated Non-Coding RNAs.
JD558529 - Sequence 539553 from Patent EP1572962.
JD331530 - Sequence 312554 from Patent EP1572962.
JD053765 - Sequence 34789 from Patent EP1572962.
JD428039 - Sequence 409063 from Patent EP1572962.
JD428038 - Sequence 409062 from Patent EP1572962.
JD202246 - Sequence 183270 from Patent EP1572962.
JD539396 - Sequence 520420 from Patent EP1572962.
JD045382 - Sequence 26406 from Patent EP1572962.
JD197538 - Sequence 178562 from Patent EP1572962.
LF345747 - JP 2014500723-A/153250: Polycomb-Associated Non-Coding RNAs.
JD206941 - Sequence 187965 from Patent EP1572962.
JD257841 - Sequence 238865 from Patent EP1572962.
JD207292 - Sequence 188316 from Patent EP1572962.
LF345748 - JP 2014500723-A/153251: Polycomb-Associated Non-Coding RNAs.
AF113690 - Homo sapiens clone FLB4718.
JD311423 - Sequence 292447 from Patent EP1572962.
JD180622 - Sequence 161646 from Patent EP1572962.
JD226878 - Sequence 207902 from Patent EP1572962.
JD051850 - Sequence 32874 from Patent EP1572962.
JD349545 - Sequence 330569 from Patent EP1572962.
LF345749 - JP 2014500723-A/153252: Polycomb-Associated Non-Coding RNAs.
JD139610 - Sequence 120634 from Patent EP1572962.
JD358492 - Sequence 339516 from Patent EP1572962.
JD358493 - Sequence 339517 from Patent EP1572962.
LF345750 - JP 2014500723-A/153253: Polycomb-Associated Non-Coding RNAs.
JD193253 - Sequence 174277 from Patent EP1572962.
JD368236 - Sequence 349260 from Patent EP1572962.
JD281942 - Sequence 262966 from Patent EP1572962.
JD327085 - Sequence 308109 from Patent EP1572962.
JD232860 - Sequence 213884 from Patent EP1572962.
JD056585 - Sequence 37609 from Patent EP1572962.
LF345752 - JP 2014500723-A/153255: Polycomb-Associated Non-Coding RNAs.
JD057086 - Sequence 38110 from Patent EP1572962.
JD050726 - Sequence 31750 from Patent EP1572962.
MA581284 - JP 2018138019-A/153210: Polycomb-Associated Non-Coding RNAs.
MA581285 - JP 2018138019-A/153211: Polycomb-Associated Non-Coding RNAs.
MA581287 - JP 2018138019-A/153213: Polycomb-Associated Non-Coding RNAs.
MA581288 - JP 2018138019-A/153214: Polycomb-Associated Non-Coding RNAs.
MA581289 - JP 2018138019-A/153215: Polycomb-Associated Non-Coding RNAs.
MA581293 - JP 2018138019-A/153219: Polycomb-Associated Non-Coding RNAs.
MA581295 - JP 2018138019-A/153221: Polycomb-Associated Non-Coding RNAs.
MA581296 - JP 2018138019-A/153222: Polycomb-Associated Non-Coding RNAs.
MA581299 - JP 2018138019-A/153225: Polycomb-Associated Non-Coding RNAs.
MA581303 - JP 2018138019-A/153229: Polycomb-Associated Non-Coding RNAs.
MA581336 - JP 2018138019-A/153262: Polycomb-Associated Non-Coding RNAs.
MA581306 - JP 2018138019-A/153232: Polycomb-Associated Non-Coding RNAs.
MA581308 - JP 2018138019-A/153234: Polycomb-Associated Non-Coding RNAs.
MA581310 - JP 2018138019-A/153236: Polycomb-Associated Non-Coding RNAs.
MA581312 - JP 2018138019-A/153238: Polycomb-Associated Non-Coding RNAs.
MA581313 - JP 2018138019-A/153239: Polycomb-Associated Non-Coding RNAs.
MA581314 - JP 2018138019-A/153240: Polycomb-Associated Non-Coding RNAs.
MA581315 - JP 2018138019-A/153241: Polycomb-Associated Non-Coding RNAs.
MA581316 - JP 2018138019-A/153242: Polycomb-Associated Non-Coding RNAs.
MA581317 - JP 2018138019-A/153243: Polycomb-Associated Non-Coding RNAs.
MA581319 - JP 2018138019-A/153245: Polycomb-Associated Non-Coding RNAs.
MA581321 - JP 2018138019-A/153247: Polycomb-Associated Non-Coding RNAs.
MA581322 - JP 2018138019-A/153248: Polycomb-Associated Non-Coding RNAs.
MA581323 - JP 2018138019-A/153249: Polycomb-Associated Non-Coding RNAs.
MA581324 - JP 2018138019-A/153250: Polycomb-Associated Non-Coding RNAs.
MA581325 - JP 2018138019-A/153251: Polycomb-Associated Non-Coding RNAs.
MA581326 - JP 2018138019-A/153252: Polycomb-Associated Non-Coding RNAs.
MA581327 - JP 2018138019-A/153253: Polycomb-Associated Non-Coding RNAs.
MA581329 - JP 2018138019-A/153255: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-5996 - oleate biosynthesis

Reactome (by CSHL, EBI, and GO)

Protein O00767 (Reactome details) participates in the following event(s):

R-HSA-5690565 SCD desaturates ST-CoA to OLE-CoA
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-75105 Fatty acyl-CoA biosynthesis
R-HSA-8957322 Metabolism of steroids
R-HSA-8978868 Fatty acid metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: B2R5U0, D3DR68, ENST00000370355.1, ENST00000370355.2, FADS5 , NM_005063, O00767, Q16150, Q53GR9, Q5W037, Q5W038, Q6GSS4, Q96KF6, Q9BS07, Q9Y695, SCD1 , SCDOS , SCD_HUMAN, uc318ihu.1, uc318ihu.2
UCSC ID: ENST00000370355.3_4
RefSeq Accession: NM_005063.5
Protein: O00767 (aka ACOD_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.