ID:SDA1_HUMAN DESCRIPTION: RecName: Full=Protein SDA1 homolog; AltName: Full=Nucleolar protein 130; AltName: Full=SDA1 domain-containing protein 1; Short=hSDA; FUNCTION: Required for 60S pre-ribosomal subunits export to the cytoplasm (By similarity). INTERACTION: Q15583:TGIF1; NbExp=1; IntAct=EBI-1043768, EBI-714215; SUBCELLULAR LOCATION: Nucleus, nucleolus. TISSUE SPECIFICITY: Highly expressed in testis, kidney, spleen, brain and fetal tissues. Also expressed at lower level in heart, lung, liver, small intestine, ovary, uterus, mammary gland and placenta. POLYMORPHISM: Variations in SDAD1 may be a cause of susceptibility to seasonal allergic rhinitis (SAR). SAR is a common allergic disorder characterized by episodes of sneezing, rhinorrhea, and swelling of the nasal mucosa. MISCELLANEOUS: DAZL and PUM2 bind its 3'-UTR mRNA, suggesting that these proteins may regulate its translation. SIMILARITY: Belongs to the SDA1 family. SEQUENCE CAUTION: Sequence=AAI07896.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAA91648.1; Type=Frameshift; Positions=53; Sequence=BAB14177.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14790.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NVU7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000055 ribosomal large subunit export from nucleus GO:0015031 protein transport GO:0030036 actin cytoskeleton organization GO:0042254 ribosome biogenesis GO:0042273 ribosomal large subunit biogenesis
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
