ID:SC22B_HUMAN DESCRIPTION: RecName: Full=Vesicle-trafficking protein SEC22b; AltName: Full=ER-Golgi SNARE of 24 kDa; Short=ERS-24; Short=ERS24; AltName: Full=SEC22 vesicle-trafficking protein homolog B; AltName: Full=SEC22 vesicle-trafficking protein-like 1; FUNCTION: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. SUBUNIT: Component of two distinct SNARE complexes consisting of STX5, GOSR2/BOS1, BET1 and SEC22B or STX18, USE1L, BNIP1/SEC20L and SEC22B. YKT6 can probably replace SEC22B in either complex. SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type IV membrane protein (By similarity). Golgi apparatus membrane; Single-pass type IV membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type IV membrane protein (By similarity). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the synaptobrevin family. SIMILARITY: Contains 1 longin domain. SIMILARITY: Contains 1 v-SNARE coiled-coil homology domain. CAUTION: The reference genome displays a polymorphic premature stop codon in position 39. SEQUENCE CAUTION: Sequence=AL359758; Type=Erroneous termination; Positions=39; Note=Translated as Gln;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75396
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0006888 ER to Golgi vesicle-mediated transport GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0015031 protein transport GO:0016192 vesicle-mediated transport GO:0045732 positive regulation of protein catabolic process GO:0048208 COPII vesicle coating GO:0048280 vesicle fusion with Golgi apparatus GO:1902902 negative regulation of autophagosome assembly GO:1990668 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane GO:0006887 exocytosis
Protein O75396 (Reactome details) participates in the following event(s):
R-HSA-5694415 SEC24A,B:SEC23A bind SEC22B R-HSA-8863914 Transport of SEC22B, TAP and PLC from ER to ERGIC R-HSA-6811422 NSF ATPase activity dissociates cis-SNARE at the ER R-HSA-8863858 SEC22B, CALR, STX4, TAP and TAPBP bind R-HSA-6811417 ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi R-HSA-6811425 NSF and SNAPs bind cis-SNARE at the ER membrane R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs R-HSA-204008 SEC31:SEC13 and v-SNARE recruitment R-HSA-8951595 CALR, TAP, TAPBP dissociate from SEC22B:STX4 R-HSA-5694425 NSF ATPase activity dissociates cis-SNARE R-HSA-6811418 ARFGAPs stimulate ARF GTPase activity at the Golgi membrane R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules R-HSA-203973 Vesicle budding R-HSA-5694446 BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle R-HSA-5694441 CSNK1D phosphorylates SEC23 R-HSA-5694439 COPII coat binds TRAPPCII and RAB1:GDP R-HSA-5694423 NSF and SNAPs bind cis-SNARE complex R-HSA-5694418 RAB1:GTP binds USO1 and GORASP1:GOLGA2 R-HSA-5694409 Nucleotide exchange on RAB1 R-HSA-5694530 Cargo concentration in the ER R-HSA-1236974 ER-Phagosome pathway R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-204005 COPII-mediated vesicle transport R-HSA-199977 ER to Golgi Anterograde Transport R-HSA-1236975 Antigen processing-Cross presentation R-HSA-8856688 Golgi-to-ER retrograde transport R-HSA-199991 Membrane Trafficking R-HSA-948021 Transport to the Golgi and subsequent modification R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-5653656 Vesicle-mediated transport R-HSA-446203 Asparagine N-linked glycosylation R-HSA-1280218 Adaptive Immune System R-HSA-597592 Post-translational protein modification R-HSA-168256 Immune System R-HSA-392499 Metabolism of proteins
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Common Gene Haplotype Alleles 
