Human Gene SEPTIN10 (ENST00000356688.8_7) from GENCODE V47lift37
  Description: septin 10, transcript variant 4 (from RefSeq NM_001321498.2)
Gencode Transcript: ENST00000356688.8_7
Gencode Gene: ENSG00000186522.15_15
Transcript (Including UTRs)
   Position: hg19 chr2:110,300,559-110,371,720 Size: 71,162 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg19 chr2:110,301,699-110,371,404 Size: 69,706 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:110,300,559-110,371,720)mRNA (may differ from genome)Protein (544 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsMGIOMIM
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: B5ME97_HUMAN
DESCRIPTION: SubName: Full=Septin 10, isoform CRA_c; SubName: Full=Septin-10;
SIMILARITY: Belongs to the septin family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 32.39 RPKM in Bladder
Total median expression: 792.47 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -127.00316-0.402 Picture PostScript Text
3' UTR -237.001140-0.208 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000038 - Cell_div_GTP-bd

Pfam Domains:
PF00735 - Septin

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on B5ME97
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005525 GTP binding


-  Descriptions from all associated GenBank mRNAs
  AF146760 - Homo sapiens septin 10 mRNA, complete cds.
BC020502 - Homo sapiens septin 10, mRNA (cDNA clone MGC:10238 IMAGE:3913356), complete cds.
BC050345 - Homo sapiens septin 10, mRNA (cDNA clone MGC:51137 IMAGE:4830029), complete cds.
AK092033 - Homo sapiens cDNA FLJ34714 fis, clone MESAN2004288, highly similar to Septin-10.
AK295560 - Homo sapiens cDNA FLJ55844 complete cds, highly similar to Septin-10.
AK292038 - Homo sapiens cDNA FLJ78458 complete cds, highly similar to Homo sapiens septin 10 (SEPT10), transcript variant 1, mRNA.
KJ903874 - Synthetic construct Homo sapiens clone ccsbBroadEn_13268 SEPT10 gene, encodes complete protein.
AK021681 - Homo sapiens cDNA FLJ11619 fis, clone HEMBA1004131, moderately similar to SEPTIN 2 HOMOLOG.
HQ448247 - Synthetic construct Homo sapiens clone IMAGE:100071648; CCSB000780_01 septin 10 (SEPT10) gene, encodes complete protein.
KJ895651 - Synthetic construct Homo sapiens clone ccsbBroadEn_05045 SEPT10 gene, encodes complete protein.
AK294427 - Homo sapiens cDNA FLJ59501 complete cds, highly similar to Septin-10.
CU676536 - Synthetic construct Homo sapiens gateway clone IMAGE:100017304 5' read SEPT10 mRNA.
AB208875 - Homo sapiens mRNA for septin 10 isoform 2 variant protein.
AL353938 - Homo sapiens mRNA; cDNA DKFZp547B243 (from clone DKFZp547B243).
AK125706 - Homo sapiens cDNA FLJ43718 fis, clone TESOP2006053.
AK022682 - Homo sapiens cDNA FLJ12620 fis, clone NT2RM4001714, moderately similar to SEPTIN 2 HOMOLOG.
AL049934 - Homo sapiens mRNA; cDNA DKFZp564M1416 (from clone DKFZp564M1416).
JD326857 - Sequence 307881 from Patent EP1572962.
JD344298 - Sequence 325322 from Patent EP1572962.
JD297302 - Sequence 278326 from Patent EP1572962.
JD244445 - Sequence 225469 from Patent EP1572962.
JD491306 - Sequence 472330 from Patent EP1572962.
JD147334 - Sequence 128358 from Patent EP1572962.
JD048403 - Sequence 29427 from Patent EP1572962.
JD232257 - Sequence 213281 from Patent EP1572962.
JD515216 - Sequence 496240 from Patent EP1572962.
JD102725 - Sequence 83749 from Patent EP1572962.
AF316880 - Homo sapiens clone Shinc-1 mRNA, partial sequence.
JD057410 - Sequence 38434 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B5ME97, B5ME97_HUMAN, ENST00000356688.1, ENST00000356688.2, ENST00000356688.3, ENST00000356688.4, ENST00000356688.5, ENST00000356688.6, ENST00000356688.7, hCG_27895 , NM_001321498, SEPT10 , SEPTIN10 , uc317zrd.1
UCSC ID: ENST00000356688.8_7
RefSeq Accession: NM_001321498.2
Protein: B5ME97

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.