ID:SETB2_HUMAN DESCRIPTION: RecName: Full=Histone-lysine N-methyltransferase SETDB2; EC=2.1.1.43; AltName: Full=Chronic lymphocytic leukemia deletion region gene 8 protein; AltName: Full=Lysine N-methyltransferase 1F; AltName: Full=SET domain bifurcated 2; FUNCTION: Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. SUBCELLULAR LOCATION: Nucleus. Chromosome (Probable). TISSUE SPECIFICITY: Ubiquitous. Highest expression in heart, testis and ovary. SIMILARITY: Belongs to the histone-lysine methyltransferase family. SIMILARITY: Contains 1 MBD (methyl-CpG-binding) domain. SIMILARITY: Contains 1 pre-SET domain. SIMILARITY: Contains 1 SET domain. SEQUENCE CAUTION: Sequence=CAH56265.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=CAI10818.2; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 82199 - SET domain 54171 - DNA-binding domain
ModBase Predicted Comparative 3D Structure on Q96T68
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.