Human Gene SH3BGRL2 (ENST00000369838.6_5) from GENCODE V47lift37
  Description: SH3 domain binding glutamate rich protein like 2, transcript variant 1 (from RefSeq NM_031469.4)
Gencode Transcript: ENST00000369838.6_5
Gencode Gene: ENSG00000198478.9_8
Transcript (Including UTRs)
   Position: hg19 chr6:80,341,046-80,413,372 Size: 72,327 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr6:80,341,179-80,409,226 Size: 68,048 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:80,341,046-80,413,372)mRNA (may differ from genome)Protein (107 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SH3L2_HUMAN
DESCRIPTION: RecName: Full=SH3 domain-binding glutamic acid-rich-like protein 2; AltName: Full=Fovea-associated SH3 domain-binding protein;
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Highly expressed in brain, placenta, liver and kidney. Expressed in retina.
SIMILARITY: Belongs to the SH3BGR family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 32.95 RPKM in Thyroid
Total median expression: 556.36 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -65.90133-0.495 Picture PostScript Text
3' UTR -1071.104146-0.258 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006993 - Glut_rich_SH3-bd
IPR012336 - Thioredoxin-like_fold

Pfam Domains:
PF00462 - Glutaredoxin
PF04908 - SH3-binding, glutamic acid-rich protein

SCOP Domains:
52833 - Thioredoxin-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2CT6 - NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q9UJC5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0017124 SH3 domain binding

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0031965 nuclear membrane


-  Descriptions from all associated GenBank mRNAs
  AF340151 - Homo sapiens fovea-associated SH3 domain binding protein (FASH3) mRNA, complete cds.
BC109043 - Homo sapiens SH3 domain binding glutamic acid-rich protein like 2, mRNA (cDNA clone MGC:125696 IMAGE:40028800), complete cds.
BC109044 - Homo sapiens SH3 domain binding glutamic acid-rich protein like 2, mRNA (cDNA clone MGC:125697 IMAGE:40028802), complete cds.
AK311757 - Homo sapiens cDNA, FLJ92017, Homo sapiens SH3 domain binding glutamic acid-rich protein like 2(SH3BGRL2), mRNA.
BC040489 - Homo sapiens SH3 domain binding glutamic acid-rich protein like 2, mRNA (cDNA clone MGC:33682 IMAGE:5286092), complete cds.
AK074506 - Homo sapiens cDNA FLJ90025 fis, clone HEMBA1001184, moderately similar to SH3BGR PROTEIN.
BC052987 - Homo sapiens SH3 domain binding glutamic acid-rich protein like 2, mRNA (cDNA clone MGC:60185 IMAGE:5503583), complete cds.
BC060799 - Homo sapiens SH3 domain binding glutamic acid-rich protein like 2, mRNA (cDNA clone MGC:71608 IMAGE:30330699), complete cds.
BC070059 - Homo sapiens SH3 domain binding glutamic acid-rich protein like 2, mRNA (cDNA clone MGC:87241 IMAGE:30346325), complete cds.
KJ894895 - Synthetic construct Homo sapiens clone ccsbBroadEn_04289 SH3BGRL2 gene, encodes complete protein.
KJ899714 - Synthetic construct Homo sapiens clone ccsbBroadEn_09108 SH3BGRL2 gene, encodes complete protein.
KJ906352 - Synthetic construct Homo sapiens clone ccsbBroadEn_16022 SH3BGRL2 gene, encodes complete protein.
AJ297972 - Homo sapiens mRNA for SH3BGRL2 protein.
AK307145 - Homo sapiens cDNA, FLJ97093.
JD406187 - Sequence 387211 from Patent EP1572962.
JD142891 - Sequence 123915 from Patent EP1572962.
JD205785 - Sequence 186809 from Patent EP1572962.
JD436474 - Sequence 417498 from Patent EP1572962.
JD309515 - Sequence 290539 from Patent EP1572962.
JD067694 - Sequence 48718 from Patent EP1572962.
JD054934 - Sequence 35958 from Patent EP1572962.
JD067465 - Sequence 48489 from Patent EP1572962.
JD130184 - Sequence 111208 from Patent EP1572962.
JD238794 - Sequence 219818 from Patent EP1572962.
JD497631 - Sequence 478655 from Patent EP1572962.
JD262599 - Sequence 243623 from Patent EP1572962.
JD436606 - Sequence 417630 from Patent EP1572962.
JD563608 - Sequence 544632 from Patent EP1572962.
JD115206 - Sequence 96230 from Patent EP1572962.
JD235513 - Sequence 216537 from Patent EP1572962.
JD519964 - Sequence 500988 from Patent EP1572962.
JD056860 - Sequence 37884 from Patent EP1572962.
JD226176 - Sequence 207200 from Patent EP1572962.
JD090972 - Sequence 71996 from Patent EP1572962.
JD317082 - Sequence 298106 from Patent EP1572962.
JD206311 - Sequence 187335 from Patent EP1572962.
JD269245 - Sequence 250269 from Patent EP1572962.
JD297048 - Sequence 278072 from Patent EP1572962.
JD445786 - Sequence 426810 from Patent EP1572962.
JD111723 - Sequence 92747 from Patent EP1572962.
JD282080 - Sequence 263104 from Patent EP1572962.
JD288584 - Sequence 269608 from Patent EP1572962.
JD526107 - Sequence 507131 from Patent EP1572962.
JD280502 - Sequence 261526 from Patent EP1572962.
JD369957 - Sequence 350981 from Patent EP1572962.
JD429473 - Sequence 410497 from Patent EP1572962.
AF131754 - Homo sapiens clone 25085 mRNA sequence.
JD552545 - Sequence 533569 from Patent EP1572962.
JD042641 - Sequence 23665 from Patent EP1572962.
JD502700 - Sequence 483724 from Patent EP1572962.
JD561970 - Sequence 542994 from Patent EP1572962.
JD519674 - Sequence 500698 from Patent EP1572962.
JD392715 - Sequence 373739 from Patent EP1572962.
JD299429 - Sequence 280453 from Patent EP1572962.
JD286190 - Sequence 267214 from Patent EP1572962.
JD306774 - Sequence 287798 from Patent EP1572962.
JD085278 - Sequence 66302 from Patent EP1572962.
JD338977 - Sequence 320001 from Patent EP1572962.
JD248090 - Sequence 229114 from Patent EP1572962.
JD204057 - Sequence 185081 from Patent EP1572962.
JD426650 - Sequence 407674 from Patent EP1572962.
JD448646 - Sequence 429670 from Patent EP1572962.
JD224184 - Sequence 205208 from Patent EP1572962.
JD059126 - Sequence 40150 from Patent EP1572962.
JD419077 - Sequence 400101 from Patent EP1572962.
JD189221 - Sequence 170245 from Patent EP1572962.
JD530457 - Sequence 511481 from Patent EP1572962.
JD316632 - Sequence 297656 from Patent EP1572962.
JD170222 - Sequence 151246 from Patent EP1572962.
JD469320 - Sequence 450344 from Patent EP1572962.
JD283840 - Sequence 264864 from Patent EP1572962.
JD360273 - Sequence 341297 from Patent EP1572962.
JD376410 - Sequence 357434 from Patent EP1572962.
JD355317 - Sequence 336341 from Patent EP1572962.
JD090582 - Sequence 71606 from Patent EP1572962.
JD346906 - Sequence 327930 from Patent EP1572962.
JD130302 - Sequence 111326 from Patent EP1572962.
JD519923 - Sequence 500947 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8MQU2, ENST00000369838.1, ENST00000369838.2, ENST00000369838.3, ENST00000369838.4, ENST00000369838.5, FASH3, NM_031469, Q2VPC2, Q5VV96, Q6NSK8, Q6P9E8, Q7Z734, Q8IWD3, Q9BPY5, Q9UJC5, SH3L2_HUMAN, uc318hwz.1, uc318hwz.2
UCSC ID: ENST00000369838.6_5
RefSeq Accession: NM_031469.4
Protein: Q9UJC5 (aka SH3L2_HUMAN or SH3M_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.