ID:3BP5_HUMAN DESCRIPTION: RecName: Full=SH3 domain-binding protein 5; Short=SH3BP-5; AltName: Full=SH3 domain-binding protein that preferentially associates with BTK; FUNCTION: Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. SUBUNIT: Interacts with BTK. Interacts with all isoforms of MAPK8, MAPK9, MAPK10 and MAPK12. INTERACTION: Q06187:BTK; NbExp=4; IntAct=EBI-624860, EBI-624835; SUBCELLULAR LOCATION: Mitochondrion. TISSUE SPECIFICITY: Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate. SIMILARITY: Belongs to the SH3BP5 family. SEQUENCE CAUTION: Sequence=BAA25922.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60239
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004860 protein kinase inhibitor activity GO:0005515 protein binding GO:0017124 SH3 domain binding
Biological Process: GO:0006469 negative regulation of protein kinase activity GO:0007165 signal transduction GO:0035556 intracellular signal transduction GO:0061099 negative regulation of protein tyrosine kinase activity
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
