ID:SH3G1_HUMAN DESCRIPTION: RecName: Full=Endophilin-A2; AltName: Full=EEN fusion partner of MLL; AltName: Full=Endophilin-2; AltName: Full=Extra eleven-nineteen leukemia fusion gene protein; Short=EEN; AltName: Full=SH3 domain protein 2B; AltName: Full=SH3 domain-containing GRB2-like protein 1; FUNCTION: Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). SUBUNIT: Interacts with ARC (By similarity). Interacts with SYNJ1 and DNM1. Interacts with PDCD6IP. INTERACTION: Q7L190:DPPA4; NbExp=3; IntAct=EBI-697911, EBI-710457; Q9H788:SH2D4A; NbExp=3; IntAct=EBI-697911, EBI-747035; Q99963:SH3GL3; NbExp=3; IntAct=EBI-697911, EBI-473910; SUBCELLULAR LOCATION: Cytoplasm (By similarity). Early endosome membrane; Peripheral membrane protein (By similarity). Note=Associated with postsynaptic endosomes in hippocampal neurons (By similarity). TISSUE SPECIFICITY: Ubiquitous. Higher expression in pancreas, placenta, prostate, testis and uterus. DOMAIN: An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes (By similarity). DISEASE: Note=In some cases of acute leukemia, a translocation results in the formation of a MLL-EEN fusion gene. SIMILARITY: Belongs to the endophilin family. SIMILARITY: Contains 1 BAR domain. SIMILARITY: Contains 1 SH3 domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/EEN.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99961
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006897 endocytosis GO:0007165 signal transduction GO:0007417 central nervous system development GO:0016191 synaptic vesicle uncoating GO:0098815 modulation of excitatory postsynaptic potential GO:1900242 regulation of synaptic vesicle endocytosis GO:1900244 positive regulation of synaptic vesicle endocytosis
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
