Human Gene SH3GLB2 (ENST00000372564.8_10) from GENCODE V47lift37

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Description: SH3 domain containing GRB2 like, endophilin B2, transcript variant 2 (from RefSeq NM_020145.4)
Gencode Transcript: ENST00000372564.8_10
Gencode Gene: ENSG00000148341.18_13
Transcript (Including UTRs)
Position: hg19 chr9:131,769,315-131,790,610 Size: 21,296 Total Exon Count: 11 Strand: -
Coding Region
Position: hg19 chr9:131,770,963-131,790,433 Size: 19,471 Coding Exon Count: 11

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr9:131,769,315-131,790,610)			mRNA (may differ from genome)		Protein (395 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: SHLB2_HUMAN DESCRIPTION: RecName: Full=Endophilin-B2; AltName: Full=SH3 domain-containing GRB2-like protein B2; SUBUNIT: Homodimer, and heterodimer with SH3GLB1. INTERACTION: Q9Y371:SH3GLB1; NbExp=5; IntAct=EBI-749607, EBI-2623095; SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Detected in skeletal muscle, adipocyte, brain, lung, colon and mammary gland. SIMILARITY: Belongs to the endophilin family. SIMILARITY: Contains 1 BAR domain. SIMILARITY: Contains 1 SH3 domain. SEQUENCE CAUTION: Sequence=AAG23792.1; Type=Frameshift; Positions=122, 128; Sequence=BAB47477.2; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen C017906 3-dinitrobenzene C009505 4,4'-diaminodiphenylmethane D015127 9,10-Dimethyl-1,2-benzanthracene D016604 Aflatoxin B1 D016572 Cyclosporine D003993 Dibutyl Phthalate D004041 Dietary Fats D004997 Ethinyl Estradiol D008628 Mercury more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 112.77 RPKM in Pituitary Total median expression: 2618.56 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-115.90	177	-0.655	Picture	PostScript	Text
3' UTR	-681.90	1648	-0.414	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR004148 - BAR_dom
IPR013606 - IRSp53/MIM_homology_IMD
IPR011511 - SH3_2
IPR001452 - SH3_domain

Pfam Domains:
PF00018 - SH3 domain
PF03114 - BAR domain
PF07653 - Variant SH3 domain
PF10455 - Bin/amphiphysin/Rvs domain for vesicular trafficking
PF14604 - Variant SH3 domain

SCOP Domains:
103657 - BAR/IMD domain-like
50044 - SH3-domain

ModBase Predicted Comparative 3D Structure on Q9NR46


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding GO:0042802 identical protein binding GO:0045296 cadherin binding Cellular Component: GO:0005654 nucleoplasm GO:0005737 cytoplasm GO:0005829 cytosol

Descriptions from all associated GenBank mRNAs


	BC005843 - Homo sapiens SH3-domain GRB2-like endophilin B2, mRNA (cDNA clone IMAGE:2821405), partial cds. AF257319 - Homo sapiens SH3-containing protein SH3GLB2 mRNA, complete cds. BC014635 - Homo sapiens SH3-domain GRB2-like endophilin B2, mRNA (cDNA clone MGC:11029 IMAGE:3677306), complete cds. AF258589 - Homo sapiens PP578 mRNA, complete cds. BC008029 - Homo sapiens, clone IMAGE:3608989, mRNA. AF370433 - Homo sapiens PP9455 mRNA, complete cds. AF370426 - Homo sapiens PP6569 mRNA, complete cds. AB058751 - Homo sapiens KIAA1848 mRNA for KIAA1848 protein. JD299633 - Sequence 280657 from Patent EP1572962. JD114856 - Sequence 95880 from Patent EP1572962. JD128523 - Sequence 109547 from Patent EP1572962. JD106434 - Sequence 87458 from Patent EP1572962. JD054830 - Sequence 35854 from Patent EP1572962. AL832592 - Homo sapiens mRNA; cDNA DKFZp451L0716 (from clone DKFZp451L0716). JD396300 - Sequence 377324 from Patent EP1572962. JD466866 - Sequence 447890 from Patent EP1572962. JD084743 - Sequence 65767 from Patent EP1572962. JD171977 - Sequence 153001 from Patent EP1572962. JD530955 - Sequence 511979 from Patent EP1572962. JD222121 - Sequence 203145 from Patent EP1572962. JD281541 - Sequence 262565 from Patent EP1572962. JD559861 - Sequence 540885 from Patent EP1572962. KJ894359 - Synthetic construct Homo sapiens clone ccsbBroadEn_03753 SH3GLB2 gene, encodes complete protein. AB384306 - Synthetic construct DNA, clone: pF1KSDA1848, Homo sapiens SH3GLB2 gene for SH3 domain GRB2-like protein B2, complete cds, without stop codon, in Flexi system. EU832345 - Synthetic construct Homo sapiens clone HAIB:100067374; DKFZo008G1127 SH3-domain GRB2-like endophilin B2 protein (SH3GLB2) gene, encodes complete protein. EU832430 - Synthetic construct Homo sapiens clone HAIB:100067459; DKFZo004G1128 SH3-domain GRB2-like endophilin B2 protein (SH3GLB2) gene, encodes complete protein. JD024326 - Sequence 5350 from Patent EP1572962. JD422443 - Sequence 403467 from Patent EP1572962. JD075902 - Sequence 56926 from Patent EP1572962. JD453117 - Sequence 434141 from Patent EP1572962.

Biochemical and Signaling Pathways


	BioCarta from NCI Cancer Genome Anatomy Project h_cblPathway - CBL mediated ligand-induced downregulation of EGF receptors

Other Names for This Gene


	Alternate Gene Symbols: A6NC47, A8MPS4, ENST00000372564.1, ENST00000372564.2, ENST00000372564.3, ENST00000372564.4, ENST00000372564.5, ENST00000372564.6, ENST00000372564.7, KIAA1848, NM_020145, PP578, Q8WY61, Q96JH9, Q9NR46, SHLB2_HUMAN, uc318kal.1, uc318kal.2 UCSC ID: ENST00000372564.8_10 RefSeq Accession: NM_020145.4 Protein: Q9NR46 (aka SHLB2_HUMAN or SHB2_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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