Human Gene SH3RF3 (ENST00000309415.8_4) from GENCODE V47lift37
  Description: SH3 domain containing ring finger 3 (from RefSeq NM_001099289.3)
Gencode Transcript: ENST00000309415.8_4
Gencode Gene: ENSG00000172985.11_7
Transcript (Including UTRs)
   Position: hg19 chr2:109,745,661-110,262,211 Size: 516,551 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr2:109,745,997-110,259,248 Size: 513,252 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:109,745,661-110,262,211)mRNA (may differ from genome)Protein (882 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SH3R3_HUMAN
DESCRIPTION: RecName: Full=SH3 domain-containing RING finger protein 3; AltName: Full=Plenty of SH3s 2; AltName: Full=SH3 multiple domains protein 4;
SUBUNIT: Interacts with PAK2.
DOMAIN: The third SH3 domain mediates interaction with PAK2.
SIMILARITY: Belongs to the SH3RF family.
SIMILARITY: Contains 1 RING-type zinc finger.
SIMILARITY: Contains 4 SH3 domains.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.07 RPKM in Artery - Tibial
Total median expression: 159.51 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -175.40336-0.522 Picture PostScript Text
3' UTR -1089.402963-0.368 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000108 - p67phox
IPR001452 - SH3_domain
IPR001841 - Znf_RING
IPR013083 - Znf_RING/FYVE/PHD
IPR017907 - Znf_RING_CS

Pfam Domains:
PF00018 - SH3 domain
PF00097 - Zinc finger, C3HC4 type (RING finger)
PF07653 - Variant SH3 domain
PF13445 - RING-type zinc-finger
PF13639 - Ring finger domain
PF13923 - Zinc finger, C3HC4 type (RING finger)
PF14604 - Variant SH3 domain

SCOP Domains:
50044 - SH3-domain
57850 - RING/U-box

ModBase Predicted Comparative 3D Structure on Q8TEJ3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0046872 metal ion binding


-  Descriptions from all associated GenBank mRNAs
  AK074131 - Homo sapiens mRNA for FLJ00204 protein.
AL831825 - Homo sapiens mRNA; cDNA DKFZp547G0613 (from clone DKFZp547G0613).
DQ307286 - Homo sapiens plenty of SH3s-2 (POSH2) mRNA, partial cds.
AK093821 - Homo sapiens cDNA FLJ36502 fis, clone TKIDN1000066.

-  Other Names for This Gene
  Alternate Gene Symbols: A0SDZ7, A8MPR1, ENST00000309415.1, ENST00000309415.2, ENST00000309415.3, ENST00000309415.4, ENST00000309415.5, ENST00000309415.6, ENST00000309415.7, NM_001099289, POSH2 , Q8NDU1, Q8TEJ3, SH3MD4, SH3R3_HUMAN, uc317oni.1, uc317oni.2
UCSC ID: ENST00000309415.8_4
RefSeq Accession: NM_001099289.3
Protein: Q8TEJ3 (aka SH3R3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.