Human Gene SHC1 (ENST00000448116.7_13) from GENCODE V47lift37
Description: SHC adaptor protein 1, transcript variant 3 (from RefSeq NM_001130040.2)Gencode Transcript: ENST00000448116.7_13Gencode Gene: ENSG00000160691.19_20Transcript (Including UTRs) Position: hg19 chr1:154,934,774-154,943,223 Size: 8,450 Total Exon Count: 12 Strand: -Coding Region Position: hg19 chr1:154,936,279-154,943,002 Size: 6,724 Coding Exon Count: 12
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: SHC1_HUMAN DESCRIPTION: RecName: Full=SHC-transforming protein 1; AltName: Full=SHC-transforming protein 3; AltName: Full=SHC-transforming protein A; AltName: Full=Src homology 2 domain-containing-transforming protein C1; Short=SH2 domain protein C1;FUNCTION: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.SUBUNIT: Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR in vitro via the PID domain. Once activated, binds to GRB2. Interacts with tyrosine-phosphorylated CD3T and DDR2. Interacts with the N-terminal region of APS. Interacts with phosphorylated LRP1 and IRS4. Interacts with INPP5D/SHIP1 and INPPL1/SHIP2. Interacts with TRIM31. Interacts with PTPN6/SHP (tyrosine phosphorylated). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTT (By similarity). Interacts with ALK, GAB2, GRB7 and KIT. Interacts with FLT4 (tyrosine-phosphorylated). Interacts with EPHB1 and GRB2; activates the MAPK/ERK cascade to regulate cell migration. Interacts with PDGFRB (tyrosine-phosphorylated). Interacts with ERBB4. Interacts with TEK/TIE2 (tyrosine-phosphorylated). Interacts with the Trk receptors NTRK1, NTRK2 and NTRK3; in a phosphotyrosine-dependent manner. Interacts with PTK2/FAK1.INTERACTION: P05067:APP; NbExp=5; IntAct=EBI-78835, EBI-77613; P00533:EGFR; NbExp=5; IntAct=EBI-78835, EBI-297353; P03372-4:ESR1; NbExp=2; IntAct=EBI-78835, EBI-4309277; P62993:GRB2; NbExp=8; IntAct=EBI-78835, EBI-401755; P08069:IGF1R; NbExp=2; IntAct=EBI-1000553, EBI-475981;SUBCELLULAR LOCATION: Cytoplasm.SUBCELLULAR LOCATION: Isoform p46Shc: Mitochondrion matrix. Note=Localized to the mitochondria matrix. Targeting of isoform p46Shc to mitochondria is mediated by its first 32 amino acids, which behave as a bona fide mitochondrial targeting sequence. Isoform p52Shc and isoform p66Shc, that contain the same sequence but more internally located, display a different subcellular localization.SUBCELLULAR LOCATION: Isoform p66Shc: Mitochondrion (By similarity). Note=In case of oxidative conditions, phosphorylation at 'Ser-36' of isoform p66Shc, leads to mitochondrial accumulation (By similarity).TISSUE SPECIFICITY: Widely expressed. Expressed in neural stem cells but absent in mature neurons.DOMAIN: In response to a variety of growth factors, isoform p46Shc and isoform p52Shc bind to phosphorylated Trk receptors through their phosphotyrosine binding (PID) and/or SH2 domains. The PID and SH2 domains bind to specific phosphorylated tyrosine residues in the Asn-Pro-Xaa-Tyr(P) motif of the Trk receptors. Isoform p46Shc and isoform p52Shc are in turn phosphorylated on three tyrosine residues within the extended proline-rich domain. These phosphotyrosines act as docking site for GRB2 and thereby are involved in Ras activation (By similarity).PTM: Phosphorylated by activated epidermal growth factor receptor. Phosphorylated in response to FLT4 and KIT signaling. Isoform p46Shc and isoform p52Shc are phosphorylated on tyrosine residues of the Pro-rich domain. Isoform p66Shc is phosphorylated on Ser-36 by PRKCB upon treatment with insulin, hydrogen peroxide or irradiation with ultraviolet light (By similarity). Tyrosine phosphorylated in response to FLT3 signaling (By similarity). Tyrosine phosphorylated by activated PTK2B/PYK2 (By similarity). Tyrosine phosphorylated by ligand-activated ALK. Tyrosine phosphorylated by ligand-activated PDGFRB. Tyrosine phosphorylated by TEK/TIE2. May be tyrosine phosphorylated by activated PTK2/FAK1; tyrosine phosphorylation was seen in an astrocytoma biopsy, where PTK2/FAK1 kinase activity is high, but not in normal brain tissue.SIMILARITY: Contains 1 PID domain.SIMILARITY: Contains 1 SH2 domain.SEQUENCE CAUTION: Sequence=CAI13254.1; Type=Erroneous gene model prediction;
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR011993 - PH_like_domIPR006019 - PID_domainIPR006020 - PTyr_interaction_domIPR000980 - SH2Pfam Domains: PF00017 - SH2 domainPF00640 - Phosphotyrosine interaction domain (PTB/PID)SCOP Domains: 50729 - PH domain-like55550 - SH2 domainProtein Data Bank (PDB) 3-D Structure ModBase Predicted Comparative 3D Structure on P29353 The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BX647136 - Homo sapiens mRNA; cDNA DKFZp686J19171 (from clone DKFZp686J19171).U73377 - Human p66shc (SHC) mRNA, complete cds.BC033925 - Homo sapiens SHC (Src homology 2 domain containing) transforming protein 1, mRNA (cDNA clone MGC:39145 IMAGE:4896385), complete cds.BX647149 - Homo sapiens mRNA; cDNA DKFZp686L06171 (from clone DKFZp686L06171).HV708928 - JP 2012506450-A/26: Methods for treating eye disorders.HW061203 - JP 2012529430-A/78: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.HW061205 - JP 2012529430-A/80: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.JA482158 - Sequence 141 from Patent WO2011072091.JA482160 - Sequence 143 from Patent WO2011072091.JB252011 - Sequence 78 from Patent EP2440214.JB252013 - Sequence 80 from Patent EP2440214.JE980450 - Sequence 141 from Patent EP2862929.JE980452 - Sequence 143 from Patent EP2862929.LP764910 - Sequence 78 from Patent EP3276004.LP764912 - Sequence 80 from Patent EP3276004.X68148 - H.sapiens SHC mRNA.BC014158 - Homo sapiens SHC (Src homology 2 domain containing) transforming protein 1, mRNA (cDNA clone MGC:20839 IMAGE:4541216), complete cds.HV708929 - JP 2012506450-A/27: Methods for treating eye disorders.HW061204 - JP 2012529430-A/79: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.HW061206 - JP 2012529430-A/81: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.JA482159 - Sequence 142 from Patent WO2011072091.JA482161 - Sequence 144 from Patent WO2011072091.JB252012 - Sequence 79 from Patent EP2440214.JB252014 - Sequence 81 from Patent EP2440214.JE980451 - Sequence 142 from Patent EP2862929.JE980453 - Sequence 144 from Patent EP2862929.LP764911 - Sequence 79 from Patent EP3276004.LP764913 - Sequence 81 from Patent EP3276004.AB208849 - Homo sapiens mRNA for SHC (Src homology 2 domain containing) transforming protein 1 isoform p66Shc variant protein.AK096169 - Homo sapiens cDNA FLJ38850 fis, clone MESAN2010031, highly similar to SHC TRANSFORMING PROTEIN.JD192123 - Sequence 173147 from Patent EP1572962.JD210637 - Sequence 191661 from Patent EP1572962.JD513788 - Sequence 494812 from Patent EP1572962.JD297493 - Sequence 278517 from Patent EP1572962.JD221485 - Sequence 202509 from Patent EP1572962.JD403885 - Sequence 384909 from Patent EP1572962.JD288256 - Sequence 269280 from Patent EP1572962.JD297191 - Sequence 278215 from Patent EP1572962.JD484678 - Sequence 465702 from Patent EP1572962.JD398160 - Sequence 379184 from Patent EP1572962.BC011813 - Homo sapiens cDNA clone IMAGE:3161064, containing frame-shift errors.BC017283 - Homo sapiens cDNA clone IMAGE:4890240, containing frame-shift errors.AK296786 - Homo sapiens cDNA FLJ56101 complete cds, highly similar to SHC-transforming protein 1.AK315842 - Homo sapiens cDNA, FLJ79491 complete cds, highly similar to SHC-transforming protein 1.AK130014 - Homo sapiens cDNA FLJ26504 fis, clone KDN07054, highly similar to SHC transforming protein.JD450347 - Sequence 431371 from Patent EP1572962.JD482826 - Sequence 463850 from Patent EP1572962.JD168834 - Sequence 149858 from Patent EP1572962.JD495311 - Sequence 476335 from Patent EP1572962.JD303038 - Sequence 284062 from Patent EP1572962.JD491298 - Sequence 472322 from Patent EP1572962.JD195602 - Sequence 176626 from Patent EP1572962.AK292143 - Homo sapiens cDNA FLJ75052 complete cds, highly similar to Homo sapiens SHC (Src homology 2 domain containing) transforming protein 1 (SHC1), transcript variant 2, mRNA.AK225332 - Homo sapiens mRNA for SHC transforming protein 1 variant, clone: HEP09014.HQ448284 - Synthetic construct Homo sapiens clone IMAGE:100071687; CCSB007372_03 SHC (Src homology 2 domain containing) transforming protein 1 (SHC1) gene, encodes complete protein.KJ892137 - Synthetic construct Homo sapiens clone ccsbBroadEn_01531 SHC1 gene, encodes complete protein.AB451255 - Homo sapiens SHC1 mRNA for SHC-transforming protein 1, complete cds, clone: FLJ08067AAAN.AB451379 - Homo sapiens SHC1 mRNA for SHC-transforming protein 1, partial cds, clone: FLJ08067AAAF.AB527815 - Synthetic construct DNA, clone: pF1KB9993, Homo sapiens SHC1 gene for SHC (Src homology 2 domain containing) transforming protein 1, without stop codon, in Flexi system.CU680810 - Synthetic construct Homo sapiens gateway clone IMAGE:100017341 5' read SHC1 mRNA.DL492542 - Novel nucleic acids.DL491011 - Novel nucleic acids.JD370469 - Sequence 351493 from Patent EP1572962.JD431593 - Sequence 412617 from Patent EP1572962.JD339406 - Sequence 320430 from Patent EP1572962.JD295948 - Sequence 276972 from Patent EP1572962.JD381874 - Sequence 362898 from Patent EP1572962.JD356142 - Sequence 337166 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_epoPathway - EPO Signaling Pathwayh_il4Pathway - IL 4 signaling pathwayh_bcrPathway - BCR Signaling Pathwayh_ecmPathway - Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epitheliah_igf1Pathway - IGF-1 Signaling Pathwayh_pdgfPathway - PDGF Signaling Pathwayh_vegfPathway - VEGF, Hypoxia, and Angiogenesish_TPOPathway - TPO Signaling Pathwayh_il2Pathway - IL 2 signaling pathwayh_p38mapkPathway - p38 MAPK Signaling Pathway h_At1rPathway - Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signalingh_integrinPathway - Integrin Signaling Pathwayh_HBxPathway - Calcium Signaling by HBx of Hepatitis B virush_biopeptidesPathway - Bioactive Peptide Induced Signaling Pathwayh_ghPathway - Growth Hormone Signaling Pathwayh_il6Pathway - IL 6 signaling pathwayh_tffPathway - Trefoil Factors Initiate Mucosal Healingh_egfPathway - EGF Signaling Pathwayh_erk5Pathway - Role of Erk5 in Neuronal Survivalh_mapkPathway - MAPKinase Signaling Pathwayh_pyk2Pathway - Links between Pyk2 and Map Kinasesh_fcer1Pathway - Fc Epsilon Receptor I Signaling in Mast Cellsh_il2rbPathway - IL-2 Receptor Beta Chain in T cell Activationh_insulinPathway - Insulin Signaling Pathwayh_ngfPathway - Nerve growth factor pathway (NGF)h_ptenPathway - PTEN dependent cell cycle arrest and apoptosish_tcrPathway - T Cell Receptor Signaling Pathwayh_trkaPathway - Trka Receptor Signaling Pathwayh_erkPathway - Erk1/Erk2 Mapk Signaling pathwayh_her2Pathway - Role of ERBB2 in Signal Transduction and Oncologyh_igf1rPathway - Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylationh_il3Pathway - IL 3 signaling pathwayh_longevityPathway - The IGF-1 Receptor and Longevityh_spryPathway - Sprouty regulation of tyrosine kinase signalsReactome (by CSHL, EBI, and GO) Reactome details) participates in the following event(s):R-HSA-74740 Binding of SHC1 to insulin receptorR-HSA-177925 SHC1 binds to the phosphorylated EGF receptor:ligand complexR-HSA-204861 Interaction of Tie2 and Shc1R-HSA-432096 Activated integrin alphaIIb beta3 binds SHC1R-HSA-452091 Phosphorylation of IL2RB Y338 enables SHC recruitmentR-HSA-879934 Recruitment of SHC1 is mediated by Y593 of the common beta chainR-HSA-1225947 Binding of SHC1 to p-6Y-EGFR mutantsR-HSA-1250357 SHC1 binds P-ERBB4 isoform dimersR-HSA-1963578 SHC1 binds phosphorylated ERBB2 heterodimersR-HSA-5637766 Binding of SHC1 to p-5Y-EGFRvIIIR-HSA-8853737 2x p-5Y-RET:GDNF:GFRA complexes bind SHC1R-HSA-74746 GRB2-1:SOS1 binds p-Y427-SHC1R-HSA-74743 Dissociation of p-Y427-SHC1 from insulin receptorR-HSA-5686074 GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociatesR-HSA-74742 Phosphorylation of SHC1R-HSA-177933 SHC1 phosphorylation by phosphorylated EGFRR-HSA-452100 SHC1 bound to IL2 receptor is phosphorylatedR-HSA-1225952 Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutantsR-HSA-1250195 SHC1 phosphorylation by ERBB2 heterodimersR-HSA-1250348 Phosphorylation of SHC1 by ERBB4 homodimersR-HSA-5637796 Phosphorylation of SHC1 by p-5Y-EGFRvIIIR-HSA-167056 SHC binds to the activated TrkA receptorR-HSA-109822 MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1R-HSA-8983394 IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2R-HSA-5685366 GRB2-1:SOS1 binds p-Y-SHCR-HSA-167217 Phospho-Shc dissociates from the TrkA receptorR-HSA-177936 GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFRR-HSA-1225961 Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complexR-HSA-1250486 Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimersR-HSA-1250380 Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimersR-HSA-5637798 Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complexR-HSA-8853734 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1R-HSA-879925 SHC1 bound to the common beta chain becomes tyrosine phosphorylatedR-HSA-167019 SHC, complexed with TrkA, is tyrosine-phosphorylatedR-HSA-109807 GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RASR-HSA-453111 Phosphorylated SHC recruits GRB2:SOS1R-HSA-913374 Phosphorylated SHC1 recruits SHIPR-HSA-5672965 RAS GEFs promote RAS nucleotide exchangeR-HSA-508247 Gab2 binds the p85 subunit of Class 1A PI3 kinasesR-HSA-913424 The SHC1:SHIP1 complex is stabilized by GRB2R-HSA-5686071 GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RASR-HSA-177945 SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)R-HSA-1225957 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)R-HSA-1250463 RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimersR-HSA-1250383 RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4R-HSA-5637808 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)R-HSA-8855508 p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11R-HSA-74751 Insulin receptor signalling cascadeR-HSA-180336 SHC1 events in EGFR signalingR-HSA-210993 Tie2 SignalingR-HSA-354192 Integrin alphaIIb beta3 signalingR-HSA-9020558 Interleukin-2 signalingR-HSA-512988 Interleukin-3, 5 and GM-CSF signalingR-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer VariantsR-HSA-1250347 SHC1 events in ERBB4 signalingR-HSA-1250196 SHC1 events in ERBB2 signalingR-HSA-5637810 Constitutive Signaling by EGFRvIIIR-HSA-8853659 RET signalingR-HSA-8983432 Interleukin-15 signalingR-HSA-74749 Signal attenuationR-HSA-381038 XBP1(S) activates chaperone genesR-HSA-167044 Signalling to RASR-HSA-74752 Signaling by Insulin receptorR-HSA-177929 Signaling by EGFRR-HSA-202733 Cell surface interactions at the vascular wallR-HSA-76009 Platelet Aggregation (Plug Formation)R-HSA-9006921 Integrin signalingR-HSA-451927 Interleukin-2 family signalingR-HSA-449147 Signaling by InterleukinsR-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in CancerR-HSA-1236394 Signaling by ERBB4R-HSA-1227986 Signaling by ERBB2R-HSA-5637812 Signaling by EGFRvIII in CancerR-HSA-422475 Axon guidanceR-HSA-381070 IRE1alpha activates chaperonesR-HSA-187687 Signalling to ERKsR-HSA-9006934 Signaling by Receptor Tyrosine KinasesR-HSA-109582 HemostasisR-HSA-76002 Platelet activation, signaling and aggregationR-HSA-162582 Signal TransductionR-HSA-1280215 Cytokine Signaling in Immune systemR-HSA-1643713 Signaling by EGFR in CancerR-HSA-1266738 Developmental BiologyR-HSA-381119 Unfolded Protein Response (UPR)R-HSA-912526 Interleukin receptor SHC signalingR-HSA-187037 Signaling by NTRK1 (TRKA)R-HSA-168256 Immune SystemR-HSA-5663202 Diseases of signal transductionR-HSA-392499 Metabolism of proteinsR-HSA-5673001 RAF/MAP kinase cascadeR-HSA-166520 Signaling by NTRKsR-HSA-1643685 DiseaseR-HSA-5684996 MAPK1/MAPK3 signalingR-HSA-5683057 MAPK family signaling cascadesR-HSA-2730886 Phosphorylation of SHC by SYK kinaseR-HSA-8851888 MET binds SHC1-2R-HSA-2730844 Interaction of GRB2:SOS complex with p-SHC1R-HSA-8851890 MET phosphorylates SHC1-2R-HSA-5654404 Activated FGFR2 binds SHC1R-HSA-5654425 Activated FGFR4 binds SHC1R-HSA-5654573 Activated FGFR1 binds SHC1R-HSA-5654625 Activated FGFR3 binds SHC1R-HSA-9026493 p-Y516 of p-5Y-NTRK2 recruits SHC1R-HSA-2396599 Recruitment of GRB2:SOS to p-5Y-LATR-HSA-2730837 Recruitment of GRB2:SOS to p-10Y-NTALR-HSA-5686073 GRB2-1:SOS1 binds p-3Y-SHC1R-HSA-5686072 p-3Y-SHC1 dissociates from IGF1RR-HSA-8934446 Activated PKC phosphorylates SHC1R-HSA-2404195 IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1R-HSA-8851900 SHC1-2 bound to MET recruits GRB2:SOS1R-HSA-8934465 SHC1 binds PTPN12R-HSA-5654582 Activated FGFR1 phosphorylates SHC1R-HSA-5654407 Activated FGFR2 phosphorylates SHC1R-HSA-5654634 Activated FGFR3 phosphorylates SHC1R-HSA-5654428 Activated FGFR4 phosphorylates SHC1R-HSA-9026890 NTRK2 phosphorylates SHC1R-HSA-5654597 Activated FGFR1:p-SHC1 binds GRB2:SOS1R-HSA-5654406 Activated FGFR2:p-SHC1 binds GRB2:SOS1R-HSA-5654646 Activated FGFR3:p-SHC1 binds GRB2:SOS1R-HSA-5654423 Activated FGFR4:p-SHC1 binds GRB2:SOS1R-HSA-2396561 Recruitment of GADS:SLP-76 to p-5Y-LATR-HSA-2730848 Recruitment of GAB2 to PM and FCERI by binding to GRB2R-HSA-2404193 IGF1R phosphorylates SHC1R-HSA-9028328 SHC1 bound to activated NTRK2 recruits GRB2:SOS1R-HSA-1112666 BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphateR-HSA-2424485 Release of p-PLCG1R-HSA-2424481 Recruitment of VAV and BTK to p-SLP-76R-HSA-2730892 Recruitment of VAV to p-SLP-76R-HSA-2396594 Phosphorylation of SLP-76 by p-SYKR-HSA-2730851 Phosphorylation of SLP-76 by p-SYKR-HSA-2396606 Recruitment of PLC-gamma to SLP-76 and p-5Y-LATR-HSA-2424477 SOS mediated nucleotide exchange of RAS (SHC)R-HSA-2730842 PI3K associates with phosphorylated GAB2R-HSA-2730860 Phosphorylation of GAB2 by SYK/FYNR-HSA-5686318 GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RASR-HSA-8851899 RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and METR-HSA-5654600 Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchangeR-HSA-5654402 Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchangeR-HSA-5654647 Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchangeR-HSA-5654426 Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchangeR-HSA-2424487 Phosphorylation of PLC-gamma by p-BTK/p-SYKR-HSA-2424484 Phosphorylation of BTK by p-SYKR-HSA-2424486 Phosphorylation and activation of VAV2/VAV3 by SYKR-HSA-2730888 Phosphorylation of PLC-gammaR-HSA-2730858 Autophosphorylation of BTK/ITKR-HSA-2730840 Activation of RAC1 by VAVR-HSA-2730841 Phosphorylation and activation of VAVR-HSA-2730885 Recruitment of TEC kinases to p-SLP-76R-HSA-2730833 Phosphorylation of TEC kinases by p-SYKR-HSA-2730889 Recruitment of PAK to the membrane by binding active RAC1R-HSA-2730856 Autophosphorylation of PAKR-HSA-5672965 RAS GEFs promote RAS nucleotide exchangeR-HSA-9026891 NTRK2 activates RAS signaling through SHC1R-HSA-2424476 Activation of RAC1 by VAV2/3R-HSA-2730847 Hydrolysis of PIP2 by PLCGR-HSA-2730870 Phosphorylation of PIP2 to PIP3 by PI3KR-HSA-2871796 FCERI mediated MAPK activationR-HSA-8851805 MET activates RAS signalingR-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengersR-HSA-5654699 SHC-mediated cascade:FGFR2R-HSA-5654719 SHC-mediated cascade:FGFR4R-HSA-5654688 SHC-mediated cascade:FGFR1R-HSA-5654704 SHC-mediated cascade:FGFR3R-HSA-9026519 Activated NTRK2 signals through RASR-HSA-2454202 Fc epsilon receptor (FCERI) signalingR-HSA-6806834 Signaling by METR-HSA-2424491 DAP12 signalingR-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilizationR-HSA-2428933 SHC-related events triggered by IGF1RR-HSA-1250196 SHC1 events in ERBB2 signalingR-HSA-983705 Signaling by the B Cell Receptor (BCR)R-HSA-5654696 Downstream signaling of activated FGFR2R-HSA-5654716 Downstream signaling of activated FGFR4R-HSA-5654687 Downstream signaling of activated FGFR1R-HSA-5654708 Downstream signaling of activated FGFR3R-HSA-9006115 Signaling by NTRK2 (TRKB)R-HSA-168249 Innate Immune SystemR-HSA-9006934 Signaling by Receptor Tyrosine KinasesR-HSA-2172127 DAP12 interactionsR-HSA-2428924 IGF1R signaling cascadeR-HSA-1227986 Signaling by ERBB2R-HSA-1280218 Adaptive Immune SystemR-HSA-5654738 Signaling by FGFR2R-HSA-5654743 Signaling by FGFR4R-HSA-5654736 Signaling by FGFR1R-HSA-5654741 Signaling by FGFR3R-HSA-166520 Signaling by NTRKsR-HSA-168256 Immune SystemR-HSA-162582 Signal TransductionR-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-190236 Signaling by FGFRR-HSA-2871809 FCERI mediated Ca+2 mobilizationR-HSA-5673001 RAF/MAP kinase cascadeR-HSA-5684996 MAPK1/MAPK3 signalingR-HSA-5683057 MAPK family signaling cascadesR-HSA-5654404 Activated FGFR2 binds SHC1R-HSA-5654425 Activated FGFR4 binds SHC1R-HSA-5654573 Activated FGFR1 binds SHC1R-HSA-5654625 Activated FGFR3 binds SHC1R-HSA-9026493 p-Y516 of p-5Y-NTRK2 recruits SHC1R-HSA-5686073 GRB2-1:SOS1 binds p-3Y-SHC1R-HSA-5686072 p-3Y-SHC1 dissociates from IGF1RR-HSA-2404195 IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1R-HSA-5654597 Activated FGFR1:p-SHC1 binds GRB2:SOS1R-HSA-5654582 Activated FGFR1 phosphorylates SHC1R-HSA-5654406 Activated FGFR2:p-SHC1 binds GRB2:SOS1R-HSA-5654407 Activated FGFR2 phosphorylates SHC1R-HSA-5654646 Activated FGFR3:p-SHC1 binds GRB2:SOS1R-HSA-5654634 Activated FGFR3 phosphorylates SHC1R-HSA-5654423 Activated FGFR4:p-SHC1 binds GRB2:SOS1R-HSA-5654428 Activated FGFR4 phosphorylates SHC1R-HSA-9026890 NTRK2 phosphorylates SHC1R-HSA-2404193 IGF1R phosphorylates SHC1R-HSA-9028328 SHC1 bound to activated NTRK2 recruits GRB2:SOS1R-HSA-1112666 BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphateR-HSA-5686318 GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RASR-HSA-5654600 Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchangeR-HSA-5654402 Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchangeR-HSA-5654647 Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchangeR-HSA-5654426 Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchangeR-HSA-9026891 NTRK2 activates RAS signaling through SHC1R-HSA-5672965 RAS GEFs promote RAS nucleotide exchangeR-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengersR-HSA-5654699 SHC-mediated cascade:FGFR2R-HSA-5654719 SHC-mediated cascade:FGFR4R-HSA-5654688 SHC-mediated cascade:FGFR1R-HSA-5654704 SHC-mediated cascade:FGFR3R-HSA-9026519 Activated NTRK2 signals through RASR-HSA-2428933 SHC-related events triggered by IGF1RR-HSA-983705 Signaling by the B Cell Receptor (BCR)R-HSA-5654696 Downstream signaling of activated FGFR2R-HSA-5654716 Downstream signaling of activated FGFR4R-HSA-5654687 Downstream signaling of activated FGFR1R-HSA-5654708 Downstream signaling of activated FGFR3R-HSA-9006115 Signaling by NTRK2 (TRKB)R-HSA-2428924 IGF1R signaling cascadeR-HSA-1280218 Adaptive Immune SystemR-HSA-5654738 Signaling by FGFR2R-HSA-5654743 Signaling by FGFR4R-HSA-5654736 Signaling by FGFR1R-HSA-5654741 Signaling by FGFR3R-HSA-166520 Signaling by NTRKsR-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-168256 Immune SystemR-HSA-190236 Signaling by FGFRR-HSA-9006934 Signaling by Receptor Tyrosine KinasesR-HSA-5673001 RAF/MAP kinase cascadeR-HSA-162582 Signal TransductionR-HSA-5684996 MAPK1/MAPK3 signalingR-HSA-5683057 MAPK family signaling cascadesR-HSA-5686073 GRB2-1:SOS1 binds p-3Y-SHC1R-HSA-5686072 p-3Y-SHC1 dissociates from IGF1RR-HSA-8934446 Activated PKC phosphorylates SHC1R-HSA-2404195 IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1R-HSA-8934465 SHC1 binds PTPN12R-HSA-2404193 IGF1R phosphorylates SHC1R-HSA-5686318 GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RASR-HSA-2428933 SHC-related events triggered by IGF1RR-HSA-1250196 SHC1 events in ERBB2 signalingR-HSA-2428924 IGF1R signaling cascadeR-HSA-1227986 Signaling by ERBB2R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-9006934 Signaling by Receptor Tyrosine KinasesR-HSA-162582 Signal Transduction
Other Names for This Gene
Alternate Gene Symbols: B5BU19, D3DV78, ENST00000448116.1, ENST00000448116.2, ENST00000448116.3, ENST00000448116.4, ENST00000448116.5, ENST00000448116.6, NM_001130040, O15290, P29353, Q5T180, Q5T183, Q5T184, Q5T185, Q5T186, Q8N4K5, Q96CL1, SHC, SHC1_HUMAN, SHCA, uc320psh.1, uc320psh.2UCSC ID: ENST00000448116.7_13RefSeq Accession: NM_001130040.2 Protein: P29353
(aka SHC1_HUMAN)
Gene Model Information
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for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
