Human Gene SHCBP1 (ENST00000303383.8_8) from GENCODE V47lift37
Description: SHC binding and spindle associated 1, transcript variant 4 (from RefSeq NR_136738.2)
Gencode Transcript: ENST00000303383.8_8
Gencode Gene: ENSG00000171241.9_10
Transcript (Including UTRs)
Position: hg19 chr16:46,612,503-46,655,291 Size: 42,789 Total Exon Count: 13 Strand: -
Coding Region
Position: hg19 chr16:46,615,641-46,655,271 Size: 39,631 Coding Exon Count: 13
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: SHCBP_HUMAN
DESCRIPTION: RecName: Full=SHC SH2 domain-binding protein 1;
FUNCTION: May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells (By similarity).SUBUNIT: Interacts directly with isoform p52shc of SHC1 via its SH2 domain. Interacts with TRIM71; leading to enhance SHCBP1 protein stability (By similarity).SIMILARITY: Contains 5 PbH1 repeats.SEQUENCE CAUTION: Sequence=BAB15208.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
D001564
Benzo(a)pyrene
D013749
Tetrachlorodibenzodioxin
C028474
1,4-bis(2-(3,5-dichloropyridyloxy))benzene
C029497
2,3-bis(3'-hydroxybenzyl)butyrolactone
C010914
2,4-diaminotoluene
C036990
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
C009505
4,4'-diaminodiphenylmethane
D015123
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
C547126
AZM551248
D000082
Acetaminophen
more ... click here to view the complete list
Common Gene Haplotype Alleles
Press "+" in the title bar above to open this section.
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
Press "+" in the title bar above to open this section.
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR006626 - PbH1
IPR012334 - Pectin_lyas_fold
IPR011050 - Pectin_lyase_fold/virulence
Pfam Domains: PF05048 - Periplasmic copper-binding protein (NosD)
PF13229 - Right handed beta helix region
SCOP Domains: 51126 - Pectin lyase-like
ModBase Predicted Comparative 3D Structure on Q8NEM2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
JD558837 - Sequence 539861 from Patent EP1572962.JD293521 - Sequence 274545 from Patent EP1572962.JD119327 - Sequence 100351 from Patent EP1572962.BC030699 - Homo sapiens SHC SH2-domain binding protein 1, mRNA (cDNA clone MGC:26900 IMAGE:4829528), complete cds.AK025662 - Homo sapiens cDNA: FLJ22009 fis, clone HEP07114.AK225315 - Homo sapiens mRNA for SHC SH2-domain binding protein 1 variant, clone: HEP07114.BC000960 - Homo sapiens SHC SH2-domain binding protein 1, mRNA (cDNA clone IMAGE:3451160), partial cds.AK055931 - Homo sapiens cDNA FLJ31369 fis, clone NB9N42000104, moderately similar to Mus musculus Shc binding protein (mPAL) mRNA.JD113384 - Sequence 94408 from Patent EP1572962.JD558980 - Sequence 540004 from Patent EP1572962.JD092343 - Sequence 73367 from Patent EP1572962.JD183980 - Sequence 165004 from Patent EP1572962.JD268449 - Sequence 249473 from Patent EP1572962.JD229236 - Sequence 210260 from Patent EP1572962.JD281733 - Sequence 262757 from Patent EP1572962.JD446831 - Sequence 427855 from Patent EP1572962.JD445137 - Sequence 426161 from Patent EP1572962.JD341190 - Sequence 322214 from Patent EP1572962.JD065684 - Sequence 46708 from Patent EP1572962.JD324497 - Sequence 305521 from Patent EP1572962.JD454995 - Sequence 436019 from Patent EP1572962.JD454994 - Sequence 436018 from Patent EP1572962.JD356990 - Sequence 338014 from Patent EP1572962.JD286858 - Sequence 267882 from Patent EP1572962.JD286857 - Sequence 267881 from Patent EP1572962.JD532298 - Sequence 513322 from Patent EP1572962.JD430980 - Sequence 412004 from Patent EP1572962.JD413505 - Sequence 394529 from Patent EP1572962.JD198187 - Sequence 179211 from Patent EP1572962.JD212804 - Sequence 193828 from Patent EP1572962.JD542821 - Sequence 523845 from Patent EP1572962.JD247109 - Sequence 228133 from Patent EP1572962.JD542820 - Sequence 523844 from Patent EP1572962.JD376048 - Sequence 357072 from Patent EP1572962.JD497753 - Sequence 478777 from Patent EP1572962.JD089526 - Sequence 70550 from Patent EP1572962.JD222899 - Sequence 203923 from Patent EP1572962.JD182060 - Sequence 163084 from Patent EP1572962.JD184073 - Sequence 165097 from Patent EP1572962.JD553927 - Sequence 534951 from Patent EP1572962.JD429644 - Sequence 410668 from Patent EP1572962.AK292164 - Homo sapiens cDNA FLJ78530 complete cds, highly similar to Homo sapiens SHC SH2-domain binding protein 1 (SHCBP1), mRNA.JD359517 - Sequence 340541 from Patent EP1572962.AK315706 - Homo sapiens cDNA, FLJ96805, highly similar to Homo sapiens SHC SH2-domain binding protein 1 (SHCBP1), mRNA.EU176232 - Synthetic construct Homo sapiens clone IMAGE:100006356; FLH167799.01X; RZPDo839D07250D SHC SH2-domain binding protein 1 (SHCBP1) gene, encodes complete protein.EU176536 - Synthetic construct Homo sapiens clone IMAGE:100011641; FLH263999.01L; RZPDo839D09245D SHC SH2-domain binding protein 1 (SHCBP1) gene, encodes complete protein.EU176544 - Synthetic construct Homo sapiens clone IMAGE:100011653; FLH264080.01L; RZPDo839F05257D SHC SH2-domain binding protein 1 (SHCBP1) gene, encodes complete protein.AK310430 - Homo sapiens cDNA, FLJ17472.JD408656 - Sequence 389680 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: ENST00000303383.1, ENST00000303383.2, ENST00000303383.3, ENST00000303383.4, ENST00000303383.5, ENST00000303383.6, ENST00000303383.7, NR_136738, Q8NEM2, Q96N60, Q9BVS0, Q9H6P6, SHCBP_HUMAN, uc317nfp.1, uc317nfp.2UCSC ID: ENST00000303383.8_8RefSeq Accession: NM_024745.5
Protein: Q8NEM2
(aka SHCBP_HUMAN)
Gene Model Information
Click here
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
Click here
for details on how this gene model was made and data restrictions if any.