ID:SHOX2_HUMAN DESCRIPTION: RecName: Full=Short stature homeobox protein 2; AltName: Full=Homeobox protein Og12X; AltName: Full=Paired-related homeobox protein SHOT; FUNCTION: May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in heart, skeletal muscle, liver, lung, bone marrow fibroblast, pancreas and placenta. DEVELOPMENTAL STAGE: Expressed during cranofacial development as well as in heart. SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily. SIMILARITY: Contains 1 homeobox DNA-binding domain. SEQUENCE CAUTION: Sequence=AAC39662.1; Type=Erroneous initiation; Sequence=CAA05341.1; Type=Erroneous initiation; Sequence=CAA05342.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 46689 - Homeodomain-like 88659 - Sigma3 and sigma4 domains of RNA polymerase sigma factors
ModBase Predicted Comparative 3D Structure on O60902
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001501 skeletal system development GO:0001649 osteoblast differentiation GO:0002053 positive regulation of mesenchymal cell proliferation GO:0002062 chondrocyte differentiation GO:0002063 chondrocyte development GO:0003170 heart valve development GO:0003209 cardiac atrium morphogenesis GO:0006355 regulation of transcription, DNA-templated GO:0007275 multicellular organism development GO:0007399 nervous system development GO:0007507 heart development GO:0030326 embryonic limb morphogenesis GO:0032330 regulation of chondrocyte differentiation GO:0035115 embryonic forelimb morphogenesis GO:0045880 positive regulation of smoothened signaling pathway GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048557 embryonic digestive tract morphogenesis GO:0048598 embryonic morphogenesis GO:0048743 positive regulation of skeletal muscle fiber development GO:0050772 positive regulation of axonogenesis GO:0060272 embryonic skeletal joint morphogenesis GO:0060351 cartilage development involved in endochondral bone morphogenesis GO:0060415 muscle tissue morphogenesis GO:2000172 regulation of branching morphogenesis of a nerve
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
