ID:SHRM3_HUMAN DESCRIPTION: RecName: Full=Protein Shroom3; AltName: Full=Shroom-related protein; Short=hShrmL; FUNCTION: Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). SUBUNIT: Interacts with F-actin (By similarity). SUBCELLULAR LOCATION: Cell junction, adherens junction (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Colocalizes with F-actin in stress fibers and adherens junctions (By similarity). DOMAIN: The ASD1 domain mediates F-actin binding (By similarity). DOMAIN: The ASD2 domain is required for apical constriction induction (By similarity). SIMILARITY: Belongs to the shroom family. SIMILARITY: Contains 1 ASD1 domain. SIMILARITY: Contains 1 ASD2 domain. SIMILARITY: Contains 1 PDZ (DHR) domain. CAUTION: It is uncertain whether Met-1 or Met-2 is the initiator. Met-2 is more conserved than Met-1 among the orthologs. SEQUENCE CAUTION: Sequence=AAQ13515.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB84689.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TF72
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
