ID:SIR4_HUMAN DESCRIPTION: RecName: Full=NAD-dependent protein deacetylase sirtuin-4; EC=3.5.1.-; AltName: Full=NAD-dependent ADP-ribosyltransferase sirtuin-4; EC=2.4.2.-; AltName: Full=Regulatory protein SIR2 homolog 4; AltName: Full=SIR2-like protein 4; Flags: Precursor; FUNCTION: NAD-dependent protein ADP-ribosyl transferase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1. Inhibits GLUD1 enzyme activity. Down- regulates insulin secretion. Has no detectable protein deacetylase activity. CATALYTIC ACTIVITY: NAD(+) + a protein = nicotinamide + an N-(ADP- D-ribosyl)-protein. CATALYTIC ACTIVITY: NAD(+) + an acetylprotein = nicotinamide + O- acetyl-ADP-ribose + a protein. COFACTOR: Binds 1 zinc ion per subunit (By similarity). SUBUNIT: Interacts with GLUD1, IDE and SLC25A5. INTERACTION: P05141:SLC25A5; NbExp=2; IntAct=EBI-2606540, EBI-355133; SUBCELLULAR LOCATION: Mitochondrion matrix. TISSUE SPECIFICITY: Detected in vascular smooth muscle and striated muscle. Detected in insulin-producing beta-cells in pancreas islets of Langerhans (at protein level). Widely expressed. Weakly expressed in leukocytes and fetal thymus. MISCELLANEOUS: The reported ADP-ribosyltransferase activity of sirtuins may be an inefficient side reaction of the deacetylase activity and may not be physiologically relevant (By similarity). SIMILARITY: Belongs to the sirtuin family. Class II subfamily. SIMILARITY: Contains 1 deacetylase sirtuin-type domain. SEQUENCE CAUTION: Sequence=AAB95634.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y6E7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000820 regulation of glutamine family amino acid metabolic process GO:0006342 chromatin silencing GO:0006471 protein ADP-ribosylation GO:0006541 glutamine metabolic process GO:0006974 cellular response to DNA damage stimulus GO:0007005 mitochondrion organization GO:0010667 negative regulation of cardiac muscle cell apoptotic process GO:0034983 peptidyl-lysine deacetylation GO:0046322 negative regulation of fatty acid oxidation GO:0046676 negative regulation of insulin secretion GO:0046889 positive regulation of lipid biosynthetic process GO:0071456 cellular response to hypoxia GO:0072350 tricarboxylic acid metabolic process GO:1903217 negative regulation of protein processing involved in protein targeting to mitochondrion GO:1904182 regulation of pyruvate dehydrogenase activity
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
