ID:SKA1_HUMAN DESCRIPTION: RecName: Full=Spindle and kinetochore-associated protein 1; FUNCTION: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules. SUBUNIT: Component of the SKA1 complex, composed of SKA1, SKA2 and SKA3. Forms a heterodimer with SKA2; the heterodimer interacting with SKA3. The core SKA1 complex is composed of 2 SKA1-SKA2 heterodimers, each heterodimer interacting with a molecule of the SKA3 homodimer. The core SKA1 complex associates with microtubules and forms oligomeric assemblies. Interacts directly with microtubules, SKA2 and SKA3. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore-associated proteins. Associates with kinetochores following microtubule attachment from prometaphase, through mid- anaphase and then vanishes in telophase. SIMILARITY: Belongs to the SKA1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96BD8
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
JF432641 - Synthetic construct Homo sapiens clone IMAGE:100073878 chromosome 18 open reading frame 24 (C18orf24) gene, encodes complete protein. KJ895848 - Synthetic construct Homo sapiens clone ccsbBroadEn_05242 SKA1 gene, encodes complete protein. LF211093 - JP 2014500723-A/18596: Polycomb-Associated Non-Coding RNAs. BC015706 - Homo sapiens chromosome 18 open reading frame 24, mRNA (cDNA clone MGC:10200 IMAGE:3909951), complete cds. AK313968 - Homo sapiens cDNA, FLJ94615. AK303464 - Homo sapiens cDNA FLJ52985 complete cds. JD317044 - Sequence 298068 from Patent EP1572962. JD369106 - Sequence 350130 from Patent EP1572962. JD226639 - Sequence 207663 from Patent EP1572962. JD143374 - Sequence 124398 from Patent EP1572962. LF343962 - JP 2014500723-A/151465: Polycomb-Associated Non-Coding RNAs. JD090794 - Sequence 71818 from Patent EP1572962. JD219363 - Sequence 200387 from Patent EP1572962. JD432788 - Sequence 413812 from Patent EP1572962. JD202319 - Sequence 183343 from Patent EP1572962. JD432793 - Sequence 413817 from Patent EP1572962. JD295756 - Sequence 276780 from Patent EP1572962. JD295757 - Sequence 276781 from Patent EP1572962. JD546590 - Sequence 527614 from Patent EP1572962. JD246635 - Sequence 227659 from Patent EP1572962. JD541864 - Sequence 522888 from Patent EP1572962. JD040550 - Sequence 21574 from Patent EP1572962. JD052865 - Sequence 33889 from Patent EP1572962. JD504438 - Sequence 485462 from Patent EP1572962. JD504439 - Sequence 485463 from Patent EP1572962. JD560126 - Sequence 541150 from Patent EP1572962. JD090931 - Sequence 71955 from Patent EP1572962. JD466797 - Sequence 447821 from Patent EP1572962. JD444260 - Sequence 425284 from Patent EP1572962. JD506082 - Sequence 487106 from Patent EP1572962. JD213807 - Sequence 194831 from Patent EP1572962. JD198832 - Sequence 179856 from Patent EP1572962. JD154404 - Sequence 135428 from Patent EP1572962. JD166666 - Sequence 147690 from Patent EP1572962. JD296915 - Sequence 277939 from Patent EP1572962. JD321206 - Sequence 302230 from Patent EP1572962. BC005972 - Homo sapiens cDNA clone IMAGE:4094587. JD326119 - Sequence 307143 from Patent EP1572962. JD548600 - Sequence 529624 from Patent EP1572962. JD261672 - Sequence 242696 from Patent EP1572962. JD430403 - Sequence 411427 from Patent EP1572962. JD557508 - Sequence 538532 from Patent EP1572962. JD557507 - Sequence 538531 from Patent EP1572962. JD529583 - Sequence 510607 from Patent EP1572962. JD529582 - Sequence 510606 from Patent EP1572962. JD169998 - Sequence 151022 from Patent EP1572962. JD170000 - Sequence 151024 from Patent EP1572962. JD169999 - Sequence 151023 from Patent EP1572962. JD310834 - Sequence 291858 from Patent EP1572962. BC015606 - Homo sapiens chromosome 18 open reading frame 24, mRNA (cDNA clone IMAGE:4761969), partial cds. JD549665 - Sequence 530689 from Patent EP1572962. JD492293 - Sequence 473317 from Patent EP1572962. JD099851 - Sequence 80875 from Patent EP1572962. JD360722 - Sequence 341746 from Patent EP1572962. JD385818 - Sequence 366842 from Patent EP1572962. JD511267 - Sequence 492291 from Patent EP1572962. JD515471 - Sequence 496495 from Patent EP1572962. JD183093 - Sequence 164117 from Patent EP1572962. JD469235 - Sequence 450259 from Patent EP1572962. JD170709 - Sequence 151733 from Patent EP1572962. JD510779 - Sequence 491803 from Patent EP1572962. JD170855 - Sequence 151879 from Patent EP1572962. JD486319 - Sequence 467343 from Patent EP1572962. JD295524 - Sequence 276548 from Patent EP1572962. MA579539 - JP 2018138019-A/151465: Polycomb-Associated Non-Coding RNAs. MA446670 - JP 2018138019-A/18596: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q96BD8 (Reactome details) participates in the following event(s):
R-HSA-141409 Mad1 binds kinetochore R-HSA-375302 Kinetochore capture of astral microtubules R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex R-HSA-141439 Release of activated MAD2 from kinetochores R-HSA-2467811 Separation of sister chromatids R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-68877 Mitotic Prometaphase R-HSA-5663220 RHO GTPases Activate Formins R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2467813 Separation of Sister Chromatids R-HSA-141424 Amplification of signal from the kinetochores R-HSA-68886 M Phase R-HSA-195258 RHO GTPase Effectors R-HSA-68882 Mitotic Anaphase R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-69278 Cell Cycle (Mitotic) R-HSA-194315 Signaling by Rho GTPases R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69620 Cell Cycle Checkpoints R-HSA-1640170 Cell Cycle R-HSA-162582 Signal Transduction
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
