ID:SKP2_HUMAN DESCRIPTION: RecName: Full=S-phase kinase-associated protein 2; AltName: Full=Cyclin-A/CDK2-associated protein p45; AltName: Full=F-box protein Skp2; AltName: Full=F-box/LRR-repeat protein 1; AltName: Full=p45skp2; FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, MLL, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Part of a SCF(SKP2) complex consisting of CUL1, RBX1, SKP1 and SKP2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Interacts directly with CUL1 and SKP1. Interacts with CKS1. Interacts with the cyclin-A-CDK2 complex. Interacts with ORC1, phosphorylated CDT1, phosphorylated RBL2, ELF4, phosphorylated RAG2, FOXO1, UBP43, MYC, TOB1, TAL1 and MLL. Interacts with TRIM21. INTERACTION: Self; NbExp=3; IntAct=EBI-456291, EBI-456291; P09803:Cdh1 (xeno); NbExp=2; IntAct=EBI-456291, EBI-984420; P46527:CDKN1B; NbExp=2; IntAct=EBI-456291, EBI-519280; P61024:CKS1B; NbExp=3; IntAct=EBI-456291, EBI-456371; Q13616:CUL1; NbExp=8; IntAct=EBI-456291, EBI-359390; P28562:DUSP1; NbExp=3; IntAct=EBI-456291, EBI-975493; Q09472:EP300; NbExp=3; IntAct=EBI-456291, EBI-447295; Q9UM11:FZR1; NbExp=2; IntAct=EBI-456291, EBI-724997; P01106:MYC; NbExp=2; IntAct=EBI-456291, EBI-447544; Q13415:ORC1; NbExp=2; IntAct=EBI-456291, EBI-374847; Q9NTG7:SIRT3; NbExp=5; IntAct=EBI-456291, EBI-724621; P63208:SKP1; NbExp=6; IntAct=EBI-456291, EBI-307486; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. PTM: Ubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Deubiquitinated by USP13. PTM: Acetylation at Lys-68 and Lys-71 increases stability through impairment of APC/C-mediated proteolysis and promotes cytoplasmic retention. Deacetylated by SIRT3. SIMILARITY: Contains 1 F-box domain. SIMILARITY: Contains 10 LRR (leucine-rich) repeats. SEQUENCE CAUTION: Sequence=AAC50242.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAB87202.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13309
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004842 ubiquitin-protein transferase activity GO:0005515 protein binding GO:0042802 identical protein binding GO:0061630 ubiquitin protein ligase activity
Biological Process: GO:0000082 G1/S transition of mitotic cell cycle GO:0000086 G2/M transition of mitotic cell cycle GO:0000209 protein polyubiquitination GO:0006511 ubiquitin-dependent protein catabolic process GO:0008283 cell proliferation GO:0016567 protein ubiquitination GO:0016579 protein deubiquitination GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway GO:0042981 regulation of apoptotic process GO:0043687 post-translational protein modification GO:0048661 positive regulation of smooth muscle cell proliferation GO:0051726 regulation of cell cycle GO:0071460 cellular response to cell-matrix adhesion GO:1902916 positive regulation of protein polyubiquitination
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
