Human Gene SLC1A5 (ENST00000542575.6_8) from GENCODE V47lift37
  Description: solute carrier family 1 member 5, transcript variant 1 (from RefSeq NM_005628.3)
Gencode Transcript: ENST00000542575.6_8
Gencode Gene: ENSG00000105281.13_12
Transcript (Including UTRs)
   Position: hg19 chr19:47,278,140-47,291,851 Size: 13,712 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr19:47,278,767-47,291,222 Size: 12,456 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:47,278,140-47,291,851)mRNA (may differ from genome)Protein (541 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: AAAT_HUMAN
DESCRIPTION: RecName: Full=Neutral amino acid transporter B(0); Short=ATB(0); AltName: Full=Baboon M7 virus receptor; AltName: Full=RD114/simian type D retrovirus receptor; AltName: Full=Sodium-dependent neutral amino acid transporter type 2; AltName: Full=Solute carrier family 1 member 5;
FUNCTION: Has a broad substrate specificity, a preference for zwitterionic amino acids, and a sodium-dependence. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated amino acids, anionic amino acids, and cationic amino acids. Acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses.
INTERACTION: O75352:MPDU1; NbExp=1; IntAct=EBI-356576, EBI-1046501; Q9HC98:NEK6; NbExp=1; IntAct=EBI-356576, EBI-740364;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Probable). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
TISSUE SPECIFICITY: Placenta, lung, skeletal muscle, kidney, pancreas, and intestine.
SIMILARITY: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A5 subfamily.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SLC1A5
Diseases sorted by gene-association score: lacrimal gland adenocarcinoma (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 100.00 RPKM in Cells - Cultured fibroblasts
Total median expression: 1101.46 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -231.10629-0.367 Picture PostScript Text
3' UTR -245.00627-0.391 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001991 - Na-dicarboxylate_symporter
IPR018107 - Na-dicarboxylate_symporter_CS

Pfam Domains:
PF00375 - Sodium:dicarboxylate symporter family

SCOP Domains:
118215 - Proton glutamate symport protein

ModBase Predicted Comparative 3D Structure on Q15758
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001618 virus receptor activity
GO:0005515 protein binding
GO:0015171 amino acid transmembrane transporter activity
GO:0015175 neutral amino acid transmembrane transporter activity
GO:0015186 L-glutamine transmembrane transporter activity
GO:0015194 L-serine transmembrane transporter activity
GO:0015293 symporter activity
GO:0038023 signaling receptor activity

Biological Process:
GO:0006865 amino acid transport
GO:0006868 glutamine transport
GO:0007165 signal transduction
GO:0010585 glutamine secretion
GO:0015804 neutral amino acid transport
GO:0015825 L-serine transport
GO:0016032 viral process
GO:0046718 viral entry into host cell
GO:1903803 L-glutamine import into cell

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042470 melanosome
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AF334818 - Homo sapiens sodium-dependent neutral amino acid transporter type 2 truncated isoform (ASCT2) mRNA, partial cds.
AF102826 - Homo sapiens RD114/simian type D retrovirus receptor (RDR) mRNA, complete cds.
BC000062 - Homo sapiens solute carrier family 1 (neutral amino acid transporter), member 5, mRNA (cDNA clone MGC:1387 IMAGE:3506037), complete cds.
AF105423 - Homo sapiens sodium-dependent neutral amino acid transporter (R16) mRNA, complete cds.
E11159 - cDNAs encoding a human apoptosis related peptide.
AK299137 - Homo sapiens cDNA FLJ58403 complete cds, highly similar to Neutral amino acid transporter B(0).
AK055630 - Homo sapiens cDNA FLJ31068 fis, clone HSYRA2001232, highly similar to NEUTRAL AMINO ACID TRANSPORTER B(0).
AK125222 - Homo sapiens cDNA FLJ43232 fis, clone HCHON2001712, highly similar to Neutral amino acid transporter B.
AK292690 - Homo sapiens cDNA FLJ76460 complete cds, highly similar to Homo sapiens solute carrier family 1 (neutral amino acid transporter), member 5 (SLC1A5), mRNA.
U53347 - Human neutral amino acid transporter B mRNA, complete cds.
JD434263 - Sequence 415287 from Patent EP1572962.
JD316514 - Sequence 297538 from Patent EP1572962.
JD519358 - Sequence 500382 from Patent EP1572962.
JD253185 - Sequence 234209 from Patent EP1572962.
AK293433 - Homo sapiens cDNA FLJ58765 complete cds, highly similar to Neutral amino acid transporter B(0).
AF105230 - Homo sapiens neutral amino acid transporter (SLC1A5) mRNA, complete cds.
JD513088 - Sequence 494112 from Patent EP1572962.
JD029543 - Sequence 10567 from Patent EP1572962.
JD027185 - Sequence 8209 from Patent EP1572962.
AK301661 - Homo sapiens cDNA FLJ57638 complete cds, highly similar to Neutral amino acid transporter B(0).
JD465546 - Sequence 446570 from Patent EP1572962.
JD482298 - Sequence 463322 from Patent EP1572962.
JD370012 - Sequence 351036 from Patent EP1572962.
AK316546 - Homo sapiens cDNA, FLJ79445 complete cds, highly similar to Neutral amino acid transporter B(0).
AB209738 - Homo sapiens mRNA for solute carrier family 1 (neutral amino acid transporter), member 5 variant protein.
JD515724 - Sequence 496748 from Patent EP1572962.
GQ919058 - Homo sapiens solute carrier family 1 member 5 isoform 1 (SLC1A5) mRNA, complete cds.
KJ897563 - Synthetic construct Homo sapiens clone ccsbBroadEn_06957 SLC1A5 gene, encodes complete protein.
DQ892148 - Synthetic construct clone IMAGE:100004778; FLH183472.01X; RZPDo839C11142D solute carrier family 1 (neutral amino acid transporter), member 5 (SLC1A5) gene, encodes complete protein.
DQ895345 - Synthetic construct Homo sapiens clone IMAGE:100009805; FLH183468.01L; RZPDo839C11141D solute carrier family 1 (neutral amino acid transporter), member 5 (SLC1A5) gene, encodes complete protein.
AB527629 - Synthetic construct DNA, clone: pF1KB5081, Homo sapiens SLC1A5 gene for solute carrier family 1 (neutral amino acid transporter), member 5, without stop codon, in Flexi system.
JD021937 - Sequence 2961 from Patent EP1572962.
JD035466 - Sequence 16490 from Patent EP1572962.
E11158 - cDNAs encoding a human apoptosis related peptide.
CU674018 - Synthetic construct Homo sapiens gateway clone IMAGE:100023436 5' read SLC1A5 mRNA.
JD025219 - Sequence 6243 from Patent EP1572962.
JD035826 - Sequence 16850 from Patent EP1572962.
JD023099 - Sequence 4123 from Patent EP1572962.
JD034368 - Sequence 15392 from Patent EP1572962.
JD372165 - Sequence 353189 from Patent EP1572962.
JD387331 - Sequence 368355 from Patent EP1572962.
JD120963 - Sequence 101987 from Patent EP1572962.
JD468223 - Sequence 449247 from Patent EP1572962.
JD514324 - Sequence 495348 from Patent EP1572962.
JD440535 - Sequence 421559 from Patent EP1572962.
JD068073 - Sequence 49097 from Patent EP1572962.
JD353636 - Sequence 334660 from Patent EP1572962.
JD166982 - Sequence 148006 from Patent EP1572962.
JD308045 - Sequence 289069 from Patent EP1572962.
JD460400 - Sequence 441424 from Patent EP1572962.
JD024366 - Sequence 5390 from Patent EP1572962.
JD186170 - Sequence 167194 from Patent EP1572962.
JD482226 - Sequence 463250 from Patent EP1572962.
JD033325 - Sequence 14349 from Patent EP1572962.
JD439461 - Sequence 420485 from Patent EP1572962.
JD336157 - Sequence 317181 from Patent EP1572962.
JD192329 - Sequence 173353 from Patent EP1572962.
JD147909 - Sequence 128933 from Patent EP1572962.
JD544816 - Sequence 525840 from Patent EP1572962.
JD021583 - Sequence 2607 from Patent EP1572962.
JD028754 - Sequence 9778 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q15758 (Reactome details) participates in the following event(s):

R-HSA-352379 SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane
R-HSA-352385 SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane
R-HSA-352230 Amino acid transport across the plasma membrane
R-HSA-425374 Amino acid and oligopeptide SLC transporters
R-HSA-425393 Metabolism of nitrogenous molecules
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: A8K9H5, AAAT_HUMAN, ASCT2 , B4DR77, B4DWS4, B7ZB81, D0EYG6, E9PC01, ENST00000542575.1, ENST00000542575.2, ENST00000542575.3, ENST00000542575.4, ENST00000542575.5, M7V1, NM_005628, O95720, Q15758, Q96RL9, Q9BWQ3, Q9UNP2, RDR, RDRC, SLC1A5 , uc324tys.1, uc324tys.2
UCSC ID: ENST00000542575.6_8
RefSeq Accession: NM_005628.3
Protein: Q15758 (aka AAAT_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.