Human Gene SLC25A16 (ENST00000609923.6_7) from GENCODE V47lift37
  Description: solute carrier family 25 member 16, transcript variant 1 (from RefSeq NM_152707.4)
Gencode Transcript: ENST00000609923.6_7
Gencode Gene: ENSG00000122912.15_12
Transcript (Including UTRs)
   Position: hg19 chr10:70,237,755-70,287,280 Size: 49,526 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr10:70,243,189-70,287,132 Size: 43,944 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:70,237,755-70,287,280)mRNA (may differ from genome)Protein (332 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GDC_HUMAN
DESCRIPTION: RecName: Full=Graves disease carrier protein; Short=GDC; AltName: Full=Graves disease autoantigen; Short=GDA; AltName: Full=Mitochondrial solute carrier protein homolog; AltName: Full=Solute carrier family 25 member 16;
FUNCTION: Required for the accumulation of coenzyme A in the mitochondrial matrix.
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the mitochondrial carrier family.
SIMILARITY: Contains 3 Solcar repeats.
SEQUENCE CAUTION: Sequence=AAA36329.1; Type=Frameshift; Positions=320;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SLC25A16
Diseases sorted by gene-association score: graves' disease (72), lemierre's syndrome (11), subclavian artery aneurysm (9), vertebral artery occlusion (9), basilar artery occlusion (9), cerebral arterial disease (8), hemometra (8), sphenoid sinusitis (7), cranial nerve palsy (7), subacute bacterial endocarditis (6), skull base meningioma (6), skull base neoplasm (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.23 RPKM in Liver
Total median expression: 136.33 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -59.90148-0.405 Picture PostScript Text
3' UTR -2177.205434-0.401 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002167 - Graves_DC
IPR002067 - Mit_carrier
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom

Pfam Domains:
PF00153 - Mitochondrial carrier protein

SCOP Domains:
103506 - Mitochondrial carrier

ModBase Predicted Comparative 3D Structure on P16260
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details   Gene Details
Gene SorterGene Sorter   Gene Sorter
 RGDEnsembl  SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0015291 secondary active transmembrane transporter activity
GO:0015297 antiporter activity
GO:0022857 transmembrane transporter activity

Biological Process:
GO:0006839 mitochondrial transport
GO:0009108 coenzyme biosynthetic process
GO:0055085 transmembrane transport

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC030266 - Homo sapiens solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16, mRNA (cDNA clone MGC:39851 IMAGE:5241247), complete cds.
M31659 - Human GT mitochondrial solute carrier protein homologue mRNA, complete cds.
AK298510 - Homo sapiens cDNA FLJ60777 complete cds, highly similar to Grave disease carrier protein.
AK123772 - Homo sapiens cDNA FLJ41778 fis, clone IMR322015523, highly similar to GRAVE'S DISEASE CARRIER PROTEIN.
AK290255 - Homo sapiens cDNA FLJ76073 complete cds, highly similar to Homo sapiens solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16 (SLC25A16), mRNA.
AK295287 - Homo sapiens cDNA FLJ59258 complete cds, highly similar to Grave disease carrier protein.
DQ891710 - Synthetic construct clone IMAGE:100004340; FLH179316.01X; RZPDo839F02130D solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16 (SLC25A16) gene, encodes complete protein.
KJ904593 - Synthetic construct Homo sapiens clone ccsbBroadEn_13987 SLC25A16 gene, encodes complete protein.
DQ894887 - Synthetic construct Homo sapiens clone IMAGE:100009347; FLH179312.01L; RZPDo839F02129D solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16 (SLC25A16) gene, encodes complete protein.
BC023330 - Homo sapiens, clone IMAGE:4944844, mRNA.
JD160722 - Sequence 141746 from Patent EP1572962.
JD160721 - Sequence 141745 from Patent EP1572962.
JD152935 - Sequence 133959 from Patent EP1572962.
JD198301 - Sequence 179325 from Patent EP1572962.
JD325840 - Sequence 306864 from Patent EP1572962.
JD140581 - Sequence 121605 from Patent EP1572962.
JD367185 - Sequence 348209 from Patent EP1572962.
JD152934 - Sequence 133958 from Patent EP1572962.
JD198300 - Sequence 179324 from Patent EP1572962.
JD271993 - Sequence 253017 from Patent EP1572962.
JD160719 - Sequence 141743 from Patent EP1572962.
JD152933 - Sequence 133957 from Patent EP1572962.
JD194913 - Sequence 175937 from Patent EP1572962.
JD537421 - Sequence 518445 from Patent EP1572962.
JD274889 - Sequence 255913 from Patent EP1572962.
JD274888 - Sequence 255912 from Patent EP1572962.
JD496993 - Sequence 478017 from Patent EP1572962.
JD404850 - Sequence 385874 from Patent EP1572962.
JD376020 - Sequence 357044 from Patent EP1572962.
JD497708 - Sequence 478732 from Patent EP1572962.
JD222877 - Sequence 203901 from Patent EP1572962.
JD112370 - Sequence 93394 from Patent EP1572962.
JD188053 - Sequence 169077 from Patent EP1572962.
JD112369 - Sequence 93393 from Patent EP1572962.
JD277919 - Sequence 258943 from Patent EP1572962.
JD177540 - Sequence 158564 from Patent EP1572962.
JD177541 - Sequence 158565 from Patent EP1572962.
JD447034 - Sequence 428058 from Patent EP1572962.
JD321014 - Sequence 302038 from Patent EP1572962.
JD041256 - Sequence 22280 from Patent EP1572962.
JD169228 - Sequence 150252 from Patent EP1572962.
JD529141 - Sequence 510165 from Patent EP1572962.
JD557323 - Sequence 538347 from Patent EP1572962.
JD564076 - Sequence 545100 from Patent EP1572962.
JD235836 - Sequence 216860 from Patent EP1572962.
JD261869 - Sequence 242893 from Patent EP1572962.
JD556767 - Sequence 537791 from Patent EP1572962.
JD298849 - Sequence 279873 from Patent EP1572962.
JD358710 - Sequence 339734 from Patent EP1572962.
JD315622 - Sequence 296646 from Patent EP1572962.
JD488574 - Sequence 469598 from Patent EP1572962.
JD112085 - Sequence 93109 from Patent EP1572962.
JD112084 - Sequence 93108 from Patent EP1572962.
JD231531 - Sequence 212555 from Patent EP1572962.
JD441698 - Sequence 422722 from Patent EP1572962.
JD329768 - Sequence 310792 from Patent EP1572962.
JD441697 - Sequence 422721 from Patent EP1572962.
JD400409 - Sequence 381433 from Patent EP1572962.
JD393041 - Sequence 374065 from Patent EP1572962.
JD495785 - Sequence 476809 from Patent EP1572962.
JD325756 - Sequence 306780 from Patent EP1572962.
JD277937 - Sequence 258961 from Patent EP1572962.
JD470244 - Sequence 451268 from Patent EP1572962.
JD136378 - Sequence 117402 from Patent EP1572962.
CU688872 - Synthetic construct Homo sapiens gateway clone IMAGE:100016721 5' read SLC25A16 mRNA.
BC001407 - Homo sapiens solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16, mRNA (cDNA clone IMAGE:3139311), with apparent retained intron.
KJ904594 - Synthetic construct Homo sapiens clone ccsbBroadEn_13988 SLC25A16 gene, encodes complete protein.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P16260 (Reactome details) participates in the following event(s):

R-HSA-199216 SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix
R-HSA-196783 Coenzyme A biosynthesis
R-HSA-199220 Vitamin B5 (pantothenate) metabolism
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000609923.1, ENST00000609923.2, ENST00000609923.3, ENST00000609923.4, ENST00000609923.5, GDA, GDC_HUMAN, NM_152707, P16260, Q8N2U1, SLC25A16 , uc327mjv.1, uc327mjv.2
UCSC ID: ENST00000609923.6_7
RefSeq Accession: NM_152707.4
Protein: P16260 (aka GDC_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.