Human Gene SLC25A33 (ENST00000302692.7_4) from GENCODE V47lift37
  Description: solute carrier family 25 member 33 (from RefSeq NM_032315.3)
Gencode Transcript: ENST00000302692.7_4
Gencode Gene: ENSG00000171612.7_8
Transcript (Including UTRs)
   Position: hg19 chr1:9,599,524-9,645,231 Size: 45,708 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr1:9,599,751-9,642,559 Size: 42,809 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:9,599,524-9,645,231)mRNA (may differ from genome)Protein (321 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: S2533_HUMAN
DESCRIPTION: RecName: Full=Solute carrier family 25 member 33; AltName: Full=Bone marrow stromal cell mitochondrial carrier protein; Short=BMSC-MCP; Short=HuBMSC-MCP; AltName: Full=Protein PNC1;
FUNCTION: Probable mitochondrial transporter which participates in dendritic cell endocytosis. May associate with mitochondrial oxidative phosphorylation.
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in the central nervous system. Also expressed in testis and skeletal muscle. Weakly expressed in heart, liver, kidney, prostate, colon and peripheral blood leukocytes.
SIMILARITY: Belongs to the mitochondrial carrier family.
SIMILARITY: Contains 3 Solcar repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.36 RPKM in Testis
Total median expression: 160.26 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -128.80227-0.567 Picture PostScript Text
3' UTR -1074.402672-0.402 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom

Pfam Domains:
PF00153 - Mitochondrial carrier protein

SCOP Domains:
103506 - Mitochondrial carrier

ModBase Predicted Comparative 3D Structure on Q9BSK2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0015218 pyrimidine nucleotide transmembrane transporter activity

Biological Process:
GO:0000002 mitochondrial genome maintenance
GO:0002082 regulation of oxidative phosphorylation
GO:0006390 transcription from mitochondrial promoter
GO:0006839 mitochondrial transport
GO:0006864 pyrimidine nucleotide transport
GO:0007005 mitochondrion organization
GO:0008284 positive regulation of cell proliferation
GO:0030307 positive regulation of cell growth
GO:0031930 mitochondria-nucleus signaling pathway
GO:0032869 cellular response to insulin stimulus
GO:0034551 mitochondrial respiratory chain complex III assembly
GO:0051881 regulation of mitochondrial membrane potential
GO:0071156 regulation of cell cycle arrest
GO:1903426 regulation of reactive oxygen species biosynthetic process
GO:1990314 cellular response to insulin-like growth factor stimulus
GO:1990519 mitochondrial pyrimidine nucleotide import

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane


-  Descriptions from all associated GenBank mRNAs
  AJ880283 - Homo sapiens mRNA for PNC1 protein.
BC073135 - Homo sapiens solute carrier family 25, member 33, mRNA (cDNA clone MGC:87888 IMAGE:6172562), complete cds.
BC004991 - Homo sapiens solute carrier family 25, member 33, mRNA (cDNA clone MGC:4399 IMAGE:2905957), complete cds.
AF495714 - Homo sapiens mitochondrial carrier protein mRNA, complete cds; nuclear gene for mitochondrial product.
JD462484 - Sequence 443508 from Patent EP1572962.
KJ899778 - Synthetic construct Homo sapiens clone ccsbBroadEn_09172 SLC25A33 gene, encodes complete protein.
JD044871 - Sequence 25895 from Patent EP1572962.
JD433383 - Sequence 414407 from Patent EP1572962.
JD222883 - Sequence 203907 from Patent EP1572962.
JD497722 - Sequence 478746 from Patent EP1572962.
JD542665 - Sequence 523689 from Patent EP1572962.
JD481370 - Sequence 462394 from Patent EP1572962.
JD179712 - Sequence 160736 from Patent EP1572962.
JD169444 - Sequence 150468 from Patent EP1572962.
JD185438 - Sequence 166462 from Patent EP1572962.
JD366770 - Sequence 347794 from Patent EP1572962.
JD411186 - Sequence 392210 from Patent EP1572962.
JD336627 - Sequence 317651 from Patent EP1572962.
JD140421 - Sequence 121445 from Patent EP1572962.
JD518110 - Sequence 499134 from Patent EP1572962.
JD518111 - Sequence 499135 from Patent EP1572962.
JD106098 - Sequence 87122 from Patent EP1572962.
JD444836 - Sequence 425860 from Patent EP1572962.
JD431527 - Sequence 412551 from Patent EP1572962.
JD532687 - Sequence 513711 from Patent EP1572962.
JD531720 - Sequence 512744 from Patent EP1572962.
JD290186 - Sequence 271210 from Patent EP1572962.
JD321644 - Sequence 302668 from Patent EP1572962.
JD084935 - Sequence 65959 from Patent EP1572962.
JD248835 - Sequence 229859 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000302692.1, ENST00000302692.2, ENST00000302692.3, ENST00000302692.4, ENST00000302692.5, ENST00000302692.6, NM_032315, Q9BSK2, S2533_HUMAN, uc317nch.1, uc317nch.2
UCSC ID: ENST00000302692.7_4
RefSeq Accession: NM_032315.3
Protein: Q9BSK2 (aka S2533_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.