Human Gene SLC25A42 (ENST00000318596.8_4) from GENCODE V47lift37
  Description: solute carrier family 25 member 42, transcript variant 1 (from RefSeq NM_178526.5)
Gencode Transcript: ENST00000318596.8_4
Gencode Gene: ENSG00000181035.14_7
Transcript (Including UTRs)
   Position: hg19 chr19:19,174,803-19,223,839 Size: 49,037 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr19:19,206,934-19,221,685 Size: 14,752 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:19,174,803-19,223,839)mRNA (may differ from genome)Protein (318 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: S2542_HUMAN
DESCRIPTION: RecName: Full=Mitochondrial coenzyme A transporter SLC25A42; AltName: Full=Solute carrier family 25 member 42;
FUNCTION: Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'- diphosphate.
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the mitochondrial carrier family.
SIMILARITY: Contains 3 Solcar repeats.
SEQUENCE CAUTION: Sequence=AAC02758.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 36.29 RPKM in Liver
Total median expression: 497.87 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -87.40156-0.560 Picture PostScript Text
3' UTR -841.902154-0.391 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR014762 - DNA_mismatch_repair_CS
IPR002167 - Graves_DC
IPR002067 - Mit_carrier
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom

Pfam Domains:
PF00153 - Mitochondrial carrier protein

SCOP Domains:
103506 - Mitochondrial carrier

ModBase Predicted Comparative 3D Structure on Q86VD7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005347 ATP transmembrane transporter activity
GO:0015217 ADP transmembrane transporter activity
GO:0015228 coenzyme A transmembrane transporter activity
GO:0043262 adenosine-diphosphatase activity
GO:0080122 AMP transmembrane transporter activity

Biological Process:
GO:0006839 mitochondrial transport
GO:0015866 ADP transport
GO:0015867 ATP transport
GO:0035349 coenzyme A transmembrane transport
GO:0055085 transmembrane transport
GO:0080121 AMP transport

Cellular Component:
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC045598 - Homo sapiens solute carrier family 25, member 42, mRNA (cDNA clone MGC:26694 IMAGE:4819096), complete cds.
FN356975 - Homo sapiens mRNA for solute carrier family 25, member 42 (SLC25A42 gene).
AK303785 - Homo sapiens cDNA FLJ54826 complete cds, highly similar to Homo sapiens solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16 (SLC25A16), mRNA.
KJ900570 - Synthetic construct Homo sapiens clone ccsbBroadEn_09964 SLC25A42 gene, encodes complete protein.
AF521885 - Homo sapiens unknown mRNA.
BC041973 - Homo sapiens hypothetical protein MGC26694, mRNA (cDNA clone IMAGE:5302893).
JD065226 - Sequence 46250 from Patent EP1572962.
JD215136 - Sequence 196160 from Patent EP1572962.
JD203671 - Sequence 184695 from Patent EP1572962.
JD141108 - Sequence 122132 from Patent EP1572962.
JD223130 - Sequence 204154 from Patent EP1572962.
JD477286 - Sequence 458310 from Patent EP1572962.
JD193693 - Sequence 174717 from Patent EP1572962.
JD038697 - Sequence 19721 from Patent EP1572962.
JD310923 - Sequence 291947 from Patent EP1572962.
JD275107 - Sequence 256131 from Patent EP1572962.
JD464031 - Sequence 445055 from Patent EP1572962.
JD054938 - Sequence 35962 from Patent EP1572962.
JD055738 - Sequence 36762 from Patent EP1572962.
JD123326 - Sequence 104350 from Patent EP1572962.
JD271358 - Sequence 252382 from Patent EP1572962.
JD460411 - Sequence 441435 from Patent EP1572962.
JD398902 - Sequence 379926 from Patent EP1572962.
JD096277 - Sequence 77301 from Patent EP1572962.
JD156563 - Sequence 137587 from Patent EP1572962.
JD130626 - Sequence 111650 from Patent EP1572962.
JD222131 - Sequence 203155 from Patent EP1572962.
JD201811 - Sequence 182835 from Patent EP1572962.
JD108881 - Sequence 89905 from Patent EP1572962.
JD060844 - Sequence 41868 from Patent EP1572962.
JD265443 - Sequence 246467 from Patent EP1572962.
JD414229 - Sequence 395253 from Patent EP1572962.
JD482222 - Sequence 463246 from Patent EP1572962.
JD385065 - Sequence 366089 from Patent EP1572962.
JD495686 - Sequence 476710 from Patent EP1572962.
JD402804 - Sequence 383828 from Patent EP1572962.
JD254088 - Sequence 235112 from Patent EP1572962.
JD550072 - Sequence 531096 from Patent EP1572962.
JD374466 - Sequence 355490 from Patent EP1572962.
JD418816 - Sequence 399840 from Patent EP1572962.
JD543909 - Sequence 524933 from Patent EP1572962.
JD197313 - Sequence 178337 from Patent EP1572962.
JD206456 - Sequence 187480 from Patent EP1572962.
JD214972 - Sequence 195996 from Patent EP1572962.
JD424234 - Sequence 405258 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: D2T2J5, ENST00000318596.1, ENST00000318596.2, ENST00000318596.3, ENST00000318596.4, ENST00000318596.5, ENST00000318596.6, ENST00000318596.7, NM_178526, O14553, O43378, Q86VD7, S2542_HUMAN, uc317qmy.1, uc317qmy.2
UCSC ID: ENST00000318596.8_4
RefSeq Accession: NM_178526.5
Protein: Q86VD7 (aka S2542_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.