Human Gene SLC25A6 (ENST00000381401.11_7) from GENCODE V47lift37

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Description: solute carrier family 25 member 6 (from RefSeq NM_001636.4)
Gencode Transcript: ENST00000381401.11_7
Gencode Gene: ENSG00000169100.14_9
Transcript (Including UTRs)
Position: hg19 chrX:1,505,045-1,511,006 Size: 5,962 Total Exon Count: 4 Strand: -
Coding Region
Position: hg19 chrX:1,505,495-1,510,902 Size: 5,408 Coding Exon Count: 4

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chrX:1,505,045-1,511,006)			mRNA (may differ from genome)		Protein (298 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
Malacards	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: Q6I9V5_HUMAN DESCRIPTION: SubName: Full=SLC25A6 protein; SubName: Full=Solute carrier family 25 (Mitochondrial carrier; adenine nucleotide translocator), member 6; SubName: Full=cDNA, FLJ92654, highly similar to Homo sapiens solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 (SLC25A6), mRNA; SIMILARITY: Belongs to the mitochondrial carrier family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: SLC25A6 Diseases sorted by gene-association score: influenza (6), autosomal dominant progressive external ophthalmoplegia (2)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid D001554 Benzene C099555 CD 437 D004040 Dietary Carbohydrates D004317 Doxorubicin C568376 MT19c compound D015741 Metribolone D012643 Selenium D012460 Sulfasalazine D014212 Tretinoin more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 459.78 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 10357.04 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-32.90	104	-0.316	Picture	PostScript	Text
3' UTR	-139.70	450	-0.310	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR002113 - Aden_trnslctor
IPR002067 - Mit_carrier
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom

Pfam Domains:
PF00153 - Mitochondrial carrier protein

SCOP Domains:
101307 - YutG-like
103506 - Mitochondrial carrier

ModBase Predicted Comparative 3D Structure on Q6I9V5


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0022857 transmembrane transporter activity Biological Process: GO:0055085 transmembrane transport Cellular Component: GO:0005739 mitochondrion GO:0005743 mitochondrial inner membrane GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	BC031912 - Homo sapiens solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6, mRNA (cDNA clone MGC:29984 IMAGE:5141625), complete cds. BC014775 - Homo sapiens solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6, mRNA (cDNA clone MGC:17525 IMAGE:3458777), complete cds. BC008737 - Homo sapiens solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6, mRNA (cDNA clone MGC:3042 IMAGE:3342722), complete cds. GQ891512 - Homo sapiens clone HEL-S-233 epididymis secretory sperm binding protein mRNA, complete cds. JD244261 - Sequence 225285 from Patent EP1572962. JD335965 - Sequence 316989 from Patent EP1572962. AB209822 - Homo sapiens mRNA for ADP,ATP carrier protein, liver isoform T2 variant protein. AY007135 - Homo sapiens clone CDABP0051 mRNA sequence. BC007850 - Homo sapiens solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6, mRNA (cDNA clone MGC:14294 IMAGE:4136545), complete cds. BC013256 - Homo sapiens solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6, mRNA (cDNA clone IMAGE:3865895). BC035469 - Homo sapiens solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6, mRNA (cDNA clone IMAGE:3867130). BC007295 - Homo sapiens solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6, mRNA (cDNA clone MGC:15671 IMAGE:3349670), complete cds. AF076617 - Homo sapiens ADP/ATP translocase mRNA, 3'UTR. J03592 - Human ADP/ATP translocase mRNA, 3' end, clone pHAT8. JD143217 - Sequence 124241 from Patent EP1572962. BC008935 - Homo sapiens solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6, mRNA (cDNA clone MGC:2387 IMAGE:2824067), complete cds. JD160448 - Sequence 141472 from Patent EP1572962. JD296208 - Sequence 277232 from Patent EP1572962. CR457400 - Homo sapiens full open reading frame cDNA clone RZPDo834C0514D for gene SLC25A6, solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6; complete cds, incl. stopcodon. AK312336 - Homo sapiens cDNA, FLJ92654, highly similar to Homo sapiens solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 (SLC25A6), mRNA. KJ890674 - Synthetic construct Homo sapiens clone ccsbBroadEn_00068 SLC25A6 gene, encodes complete protein. KJ896425 - Synthetic construct Homo sapiens clone ccsbBroadEn_05819 SLC25A6 gene, encodes complete protein. KJ896426 - Synthetic construct Homo sapiens clone ccsbBroadEn_05820 SLC25A6 gene, encodes complete protein. DQ891478 - Synthetic construct clone IMAGE:100004108; FLH177340.01X; RZPDo839G06124D solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 (SLC25A6) gene, encodes complete protein. DQ894667 - Synthetic construct Homo sapiens clone IMAGE:100009127; FLH177337.01L; RZPDo839G06123D solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 (SLC25A6) gene, encodes complete protein. JD023307 - Sequence 4331 from Patent EP1572962. JD036339 - Sequence 17363 from Patent EP1572962. JD026831 - Sequence 7855 from Patent EP1572962.

Biochemical and Signaling Pathways


	BioCarta from NCI Cancer Genome Anatomy Project h_etcPathway - Electron Transport Reaction in Mitochondria

Other Names for This Gene


	Alternate Gene Symbols: ENST00000381401.1, ENST00000381401.10, ENST00000381401.2, ENST00000381401.3, ENST00000381401.4, ENST00000381401.5, ENST00000381401.6, ENST00000381401.7, ENST00000381401.8, ENST00000381401.9, hCG_1746794 , NM_001636, Q6I9V5, Q6I9V5_HUMAN, SLC25A6 , uc318qfv.1, uc318qfv.2 UCSC ID: ENST00000381401.11_7 RefSeq Accession: NM_001636.4 Protein: Q6I9V5

Gene Model Information


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Methods, Credits, and Use Restrictions


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