ID:S27A4_HUMAN DESCRIPTION: RecName: Full=Long-chain fatty acid transport protein 4; Short=FATP-4; Short=Fatty acid transport protein 4; EC=6.2.1.-; AltName: Full=Solute carrier family 27 member 4; FUNCTION: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Probable). TISSUE SPECIFICITY: Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tissue. DISEASE: Defects in SLC27A4 are the cause of ichthyosis prematurity syndrome (IPS) [MIM:608649]. A keratinization disorder characterized by complications in the second trimester of pregnancy resulting from polyhydramnion, with premature birth of a child with thick caseous desquamating epidermis, respiratory complications and transient eosinophilia. After recovery during the first months of life, the symptoms are relatively benign and the patients suffer from a lifelong non-scaly ichthyosis with atopic manifestations. MISCELLANEOUS: SLC27A4/FATP4-mediated fatty acid uptake is associated to paramaters related to insulin resistance, which is associated with disturbed fatty acid metabolism and homeostasis, such as obesity. SLC27A4/FATP4 expression is positively correlated with acquired obesity. SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family. SEQUENCE CAUTION: Sequence=AAD11623.1; Type=Frameshift; Positions=362, 387, 612, 619;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6P1M0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000038 very long-chain fatty acid metabolic process GO:0001579 medium-chain fatty acid transport GO:0001676 long-chain fatty acid metabolic process GO:0006629 lipid metabolic process GO:0006631 fatty acid metabolic process GO:0006869 lipid transport GO:0007584 response to nutrient GO:0008152 metabolic process GO:0015908 fatty acid transport GO:0015909 long-chain fatty acid transport GO:0042760 very long-chain fatty acid catabolic process GO:0043588 skin development GO:0044539 long-chain fatty acid import
HZ408867 - JP 2015528002-A/1464: CHIRAL CONTROL. HZ460764 - WO 2015190584-A/261: Kit or device and method for detecting prostate cancer. HZ461557 - WO 2015190586-A/370: Kit and method for detecting colon cancer. HZ462268 - WO 2015190591-A/423: Kit and method for detecting breast cancer. HZ463251 - WO 2015194535-A/345: Kit and method for detecting stomach cancer. HZ463895 - WO 2015194610-A/331: Kit and method for detecting lung cancer. HZ465315 - WO 2015194627-A/368: Kit and method for detecting esophageal cancer. LG052201 - KR 1020150036642-A/1467: CHIRAL CONTROL. LY496498 - KR 1020170018406-A/368: ESOPHAGEAL CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY497200 - KR 1020170016485-A/370: COLORECTAL CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY497796 - KR 1020170018409-A/331: KIT OR DEVICE FOR DETECTING LUNG CANCER, AND LUNG CANCER DETECTION METHOD. LY499271 - KR 1020170018412-A/423: BREAST CANCER DETECTION KIT OR DEVICE, AND METHOD FOR DETECTING BREAST CANCER. LY500064 - KR 1020170019425-A/345: STOMACH CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LY500637 - KR 1020170016490-A/261: PROSTATE CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD. LZ238749 - WO 2017171048-A/410: Kit, device and method for detecting early pancreatic cancer or precancerous lesion of pancreas. MS869556 - Sequence 261 from Patent EP3156483. MS880586 - Sequence 423 from Patent EP3156498. MS884387 - Sequence 370 from Patent EP3156499. MS885183 - Sequence 345 from Patent EP3156503. MS994506 - Sequence 368 from Patent EP3159406. MS996862 - Sequence 331 from Patent EP3159416. MA806041 - WO 2018199275-A/301: Kit, device and method for detection of ovary tumor. MA822707 - WO 2019004436-A/520: Kit, device, and method for detection of lung cancer. LY616513 - KR 1020180129785-A/410: KIT OR DEVICE FOR DETECTING EARLY STAGE PANCREATIC CANCER OR PANCREATIC CANCER PRECURSOR LESIONS AND DETECTION METHOD THEREFOR. MB472857 - WO 2019208671-A/256: Kit or device and method for detecting bladder cancer. AK290222 - Homo sapiens cDNA FLJ76070 complete cds, highly similar to Homo sapiens solute carrier family 27 (fatty acid transporter), member 4 (SLC27A4), mRNA. BC065003 - Homo sapiens solute carrier family 27 (fatty acid transporter), member 4, mRNA (cDNA clone MGC:75102 IMAGE:6023438), complete cds. BC009959 - Homo sapiens solute carrier family 27 (fatty acid transporter), member 4, mRNA (cDNA clone IMAGE:4131025), complete cds. AK314681 - Homo sapiens cDNA, FLJ95532. DD153956 - New method. DD153957 - New method. KJ902184 - Synthetic construct Homo sapiens clone ccsbBroadEn_11578 SLC27A4 gene, encodes complete protein. AF055899 - Homo sapiens fatty acid transport protein (FATP) mRNA, complete cds. AK027504 - Homo sapiens cDNA FLJ14598 fis, clone NT2RM4002558, highly similar to Long-chain fatty acid transport protein 4 (EC 6.2.1.-). AK074831 - Homo sapiens cDNA FLJ90350 fis, clone NT2RP2003210, highly similar to Long-chain fatty acid transport protein 4 (EC 6.2.1.-). BC004268 - Homo sapiens, clone IMAGE:3613739, mRNA, partial cds. AK000722 - Homo sapiens cDNA FLJ20715 fis, clone HUV00206, highly similar to AF055899 Homo sapiens fatty acid transport protein.
Protein Q6P1M0 (Reactome details) participates in the following event(s):
R-HSA-879585 SLC27A1,4,6 transport LCFAs from extracellular region to cytosol R-HSA-804914 Transport of fatty acids R-HSA-425397 Transport of vitamins, nucleosides, and related molecules R-HSA-425407 SLC-mediated transmembrane transport R-HSA-382551 Transport of small molecules
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
