ID:S40A1_HUMAN DESCRIPTION: RecName: Full=Solute carrier family 40 member 1; AltName: Full=Ferroportin-1; AltName: Full=Iron-regulated transporter 1; FUNCTION: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). INTERACTION: P05067:APP; NbExp=4; IntAct=EBI-725153, EBI-77613; SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=Localized to the basolateral membrane of polarized epithelial cells. TISSUE SPECIFICITY: Expressed in placenta, intestine, muscle and spleen. DISEASE: Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4) [MIM:606069]. HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation. SIMILARITY: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SLC40A1";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 103473 - MFS general substrate transporter
ModBase Predicted Comparative 3D Structure on Q9NP59
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005381 iron ion transmembrane transporter activity GO:0005515 protein binding GO:0015093 ferrous iron transmembrane transporter activity GO:0017046 peptide hormone binding GO:0042802 identical protein binding GO:0097689 iron channel activity
Biological Process: GO:0002260 lymphocyte homeostasis GO:0003158 endothelium development GO:0006811 ion transport GO:0006826 iron ion transport GO:0006879 cellular iron ion homeostasis GO:0034395 regulation of transcription from RNA polymerase II promoter in response to iron GO:0034755 iron ion transmembrane transport GO:0043066 negative regulation of apoptotic process GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048536 spleen development GO:0055072 iron ion homeostasis GO:0060345 spleen trabecula formation GO:0060586 multicellular organismal iron ion homeostasis GO:1903988 ferrous iron export
DQ065762 - Homo sapiens putative ferroportin 1 variant IIIA (SLC40A1) mRNA, partial cds. DQ065763 - Homo sapiens putative ferroportin 1 variant IIIB (SLC40A1) mRNA, partial cds. DQ065764 - Homo sapiens putative ferroportin 1 variant IIIC (SLC40A1) mRNA, partial cds. BX537503 - Homo sapiens mRNA; cDNA DKFZp779A1311 (from clone DKFZp779A1311). AF215636 - Homo sapiens SLC11A3 iron transporter mRNA, complete cds. AL136944 - Homo sapiens mRNA; cDNA DKFZp586J0624 (from clone DKFZp586J0624). BC037733 - Homo sapiens solute carrier family 40 (iron-regulated transporter), member 1, mRNA (cDNA clone MGC:26152 IMAGE:4823308), complete cds. LP895418 - Sequence 282 from Patent EP3253886. AK002038 - Homo sapiens cDNA FLJ11176 fis, clone PLACE1007386. JD560298 - Sequence 541322 from Patent EP1572962. AK223236 - Homo sapiens mRNA for solute carrier family 40 (iron-regulated transporter), member 1 variant, clone: STM01809. JD167419 - Sequence 148443 from Patent EP1572962. JD516103 - Sequence 497127 from Patent EP1572962. JD052620 - Sequence 33644 from Patent EP1572962. JD229041 - Sequence 210065 from Patent EP1572962. JD085271 - Sequence 66295 from Patent EP1572962. JD061869 - Sequence 42893 from Patent EP1572962. JD510079 - Sequence 491103 from Patent EP1572962. JD410872 - Sequence 391896 from Patent EP1572962. AK292146 - Homo sapiens cDNA FLJ78004 complete cds, highly similar to Homo sapiens solute carrier family 40 (iron-regulated transporter), member 1, mRNA. AF231121 - Homo sapiens iron-regulated transporter IREG1 (IREG1) mRNA, complete cds. AF147322 - Homo sapiens full length insert cDNA clone YB21H04. AF226614 - Homo sapiens ferroportin1 (FPN1) mRNA, complete cds. BC035893 - Homo sapiens solute carrier family 40 (iron-regulated transporter), member 1, mRNA (cDNA clone MGC:46472 IMAGE:5213437), complete cds. CR533564 - Homo sapiens full open reading frame cDNA clone RZPDo834H0721D for gene SLC40A1, solute carrier family 40 (iron-regulated transporter), member 1; complete cds, incl. stopcodon. JD156040 - Sequence 137064 from Patent EP1572962. JD282437 - Sequence 263461 from Patent EP1572962. AK314827 - Homo sapiens cDNA, FLJ95707, Homo sapiens solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3 (SLC11A3), mRNA. KJ898767 - Synthetic construct Homo sapiens clone ccsbBroadEn_08161 SLC40A1 gene, encodes complete protein. KR711009 - Synthetic construct Homo sapiens clone CCSBHm_00018931 SLC40A1 (SLC40A1) mRNA, encodes complete protein. KR711010 - Synthetic construct Homo sapiens clone CCSBHm_00018941 SLC40A1 (SLC40A1) mRNA, encodes complete protein. KR711011 - Synthetic construct Homo sapiens clone CCSBHm_00018956 SLC40A1 (SLC40A1) mRNA, encodes complete protein. KR711012 - Synthetic construct Homo sapiens clone CCSBHm_00018959 SLC40A1 (SLC40A1) mRNA, encodes complete protein. DQ890880 - Synthetic construct clone IMAGE:100003510; FLH166742.01X; RZPDo839C0988D solute carrier family 40 (iron-regulated transporter), member 1 (SLC40A1) gene, encodes complete protein. DQ894034 - Synthetic construct Homo sapiens clone IMAGE:100008494; FLH166738.01L; RZPDo839C0987D solute carrier family 40 (iron-regulated transporter), member 1 (SLC40A1) gene, encodes complete protein. AB463271 - Synthetic construct DNA, clone: pF1KB8672, Homo sapiens SLC40A1 gene for solute carrier family 40 (iron-regulated transporter), member 1, without stop codon, in Flexi system. AM393277 - Synthetic construct Homo sapiens clone IMAGE:100001858 for hypothetical protein (SLC40A1 gene). KJ904734 - Synthetic construct Homo sapiens clone ccsbBroadEn_14128 SLC40A1 gene, encodes complete protein. AF171087 - Homo sapiens MSTP079 (MST079) mRNA, complete cds. DQ065759 - Homo sapiens ferroportin 1 variant I (SLC40A1) mRNA, partial cds. DQ065761 - Homo sapiens ferroportin 1 variant IIB (SLC40A1) mRNA, partial cds. DQ065760 - Homo sapiens ferroportin 1 variant IIA (SLC40A1) mRNA, partial cds. JD186844 - Sequence 167868 from Patent EP1572962. JD131733 - Sequence 112757 from Patent EP1572962. JD226860 - Sequence 207884 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9NP59 (Reactome details) participates in the following event(s):
R-HSA-442368 SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region R-HSA-917933 SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ R-HSA-904830 SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region R-HSA-917891 SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ R-HSA-425410 Metal ion SLC transporters R-HSA-917937 Iron uptake and transport R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-382551 Transport of small molecules R-HSA-425407 SLC-mediated transmembrane transport
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
