ID:SC6A9_HUMAN DESCRIPTION: RecName: Full=Sodium- and chloride-dependent glycine transporter 1; Short=GlyT-1; Short=GlyT1; AltName: Full=Solute carrier family 6 member 9; FUNCTION: Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Isoform GlyT-1A and isoform GlyT-1B can be found in brain, kidney, pancreas, lung, placenta and liver but isoform GlyT-1C is only found in brain. SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily. SEQUENCE CAUTION: Sequence=AAB30784.1; Type=Frameshift; Positions=8; Sequence=AAB30785.1; Type=Frameshift; Positions=8; Sequence=CAI19428.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI19429.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P48067
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0003333 amino acid transmembrane transport GO:0006836 neurotransmitter transport GO:0006865 amino acid transport GO:0015816 glycine transport GO:0055085 transmembrane transport GO:0061537 glycine secretion, neurotransmission GO:1903825 organic acid transmembrane transport
AK295659 - Homo sapiens cDNA FLJ50533 complete cds, highly similar to Sodium-and chloride-dependent glycine transporter 1. S70609 - glycine transporter type 1b [human, substantia nigra, mRNA, 2364 nt]. S70612 - glycine transporter type 1c {alternatively spliced} [human, substantia nigra, mRNA, 2202 nt]. AK304057 - Homo sapiens cDNA FLJ59814 complete cds, highly similar to Sodium-and chloride-dependent glycine transporter 1. AK296438 - Homo sapiens cDNA FLJ56886 complete cds, highly similar to Sodium-and chloride-dependent glycine transporter 1. AK298611 - Homo sapiens cDNA FLJ50609 complete cds, highly similar to Sodium-and chloride-dependent glycine transporter 1. BC156979 - Synthetic construct Homo sapiens clone IMAGE:100062833, MGC:190627 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 (SLC6A9) mRNA, encodes complete protein. AK315233 - Homo sapiens cDNA, FLJ96233. AK315933 - Homo sapiens cDNA, FLJ78832 complete cds, highly similar to Sodium- and chloride-dependent glycine transporter 1. AK311136 - Homo sapiens cDNA, FLJ18178.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P48067 (Reactome details) participates in the following event(s):
R-HSA-444120 SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425428 Amine compound SLC transporters R-HSA-425407 SLC-mediated transmembrane transport R-HSA-382551 Transport of small molecules
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
