ID:XCT_HUMAN DESCRIPTION: RecName: Full=Cystine/glutamate transporter; AltName: Full=Amino acid transport system xc-; AltName: Full=Calcium channel blocker resistance protein CCBR1; AltName: Full=Solute carrier family 7 member 11; AltName: Full=xCT; FUNCTION: Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. SUBUNIT: Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc (By similarity). INTERACTION: P16070:CD44; NbExp=4; IntAct=EBI-3843348, EBI-490245; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UPY5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AB040875 - Homo sapiens hxCT mRNA for cystine/glutamate exchanger, complete cds. LP747434 - Sequence 21 from Patent WO2018009939. BC041925 - Homo sapiens solute carrier family 7, (cationic amino acid transporter, y+ system) member 11, mRNA (cDNA clone IMAGE:5300264). JD481599 - Sequence 462623 from Patent EP1572962. JD370292 - Sequence 351316 from Patent EP1572962. AJ277882 - Homo sapiens mRNA for cystine/glutamate transporter (XCT gene). JD219896 - Sequence 200920 from Patent EP1572962. JD517811 - Sequence 498835 from Patent EP1572962. JD240839 - Sequence 221863 from Patent EP1572962. JD514380 - Sequence 495404 from Patent EP1572962. JD238664 - Sequence 219688 from Patent EP1572962. JD451320 - Sequence 432344 from Patent EP1572962. JD422000 - Sequence 403024 from Patent EP1572962. JD446551 - Sequence 427575 from Patent EP1572962. JD077584 - Sequence 58608 from Patent EP1572962. JD199613 - Sequence 180637 from Patent EP1572962. JD472573 - Sequence 453597 from Patent EP1572962. JD565679 - Sequence 546703 from Patent EP1572962. JD432589 - Sequence 413613 from Patent EP1572962. JD112449 - Sequence 93473 from Patent EP1572962. JD112448 - Sequence 93472 from Patent EP1572962. JD089547 - Sequence 70571 from Patent EP1572962. JD216171 - Sequence 197195 from Patent EP1572962. JD302649 - Sequence 283673 from Patent EP1572962. JD305905 - Sequence 286929 from Patent EP1572962. AF252872 - Homo sapiens cystine/glutamate transporter xCT mRNA, complete cds. JD061390 - Sequence 42414 from Patent EP1572962. JD502583 - Sequence 483607 from Patent EP1572962. BC012087 - Homo sapiens solute carrier family 7, (cationic amino acid transporter, y+ system) member 11, mRNA (cDNA clone MGC:20026 IMAGE:4562994), complete cds. AK290359 - Homo sapiens cDNA FLJ78174 complete cds, highly similar to Homo sapiens mRNA for cystine/glutamate transporter (XCT gene). JD301044 - Sequence 282068 from Patent EP1572962. JD302053 - Sequence 283077 from Patent EP1572962. JD244964 - Sequence 225988 from Patent EP1572962. JD308379 - Sequence 289403 from Patent EP1572962. AF200708 - Homo sapiens calcium channel blocker resistance protein CCBR1 mRNA, complete cds. AB026891 - Homo sapiens mRNA for cystine/glutamate transporter, complete cds. JD332604 - Sequence 313628 from Patent EP1572962. AK314855 - Homo sapiens cDNA, FLJ95753, Homo sapiens solute carrier family 7, (cationic amino acidtransporter, y+ system) member 11 (SLC7A11), mRNA. JF432710 - Synthetic construct Homo sapiens clone IMAGE:100073949 solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 (SLC7A11) gene, encodes complete protein. KJ893432 - Synthetic construct Homo sapiens clone ccsbBroadEn_02826 SLC7A11 gene, encodes complete protein. AB385133 - Synthetic construct DNA, clone: pF1KB5613, Homo sapiens SLC7A11 gene for solute carrier family 7, member 11, complete cds, without stop codon, in Flexi system. MB486574 - JP 2019531699-A/21: METHODS FOR DIAGNOSING AND TREATING CANCER.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9UPY5 (Reactome details) participates in the following event(s):
R-HSA-375131 Basigin binds CD98 complex R-HSA-378513 SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate R-HSA-210991 Basigin interactions R-HSA-352230 Amino acid transport across the plasma membrane R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-425374 Amino acid and oligopeptide SLC transporters R-HSA-425393 Metabolism of nitrogenous molecules R-HSA-109582 Hemostasis R-HSA-425407 SLC-mediated transmembrane transport R-HSA-382551 Transport of small molecules
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
