ID:SNPC5_HUMAN DESCRIPTION: RecName: Full=snRNA-activating protein complex subunit 5; Short=SNAPc subunit 5; AltName: Full=Small nuclear RNA-activating complex polypeptide 5; AltName: Full=snRNA-activating protein complex 19 kDa subunit; Short=SNAPc 19 kDa subunit; FUNCTION: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. SUBUNIT: Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC5 interacts with SNAPC4. SUBCELLULAR LOCATION: Nucleus.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75971
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006384 transcription initiation from RNA polymerase III promoter GO:0042795 snRNA transcription from RNA polymerase II promoter
LF384557 - JP 2014500723-A/192060: Polycomb-Associated Non-Coding RNAs. AK024763 - Homo sapiens cDNA: FLJ21110 fis, clone CAS05377. JD247471 - Sequence 228495 from Patent EP1572962. JD558431 - Sequence 539455 from Patent EP1572962. AK292051 - Homo sapiens cDNA FLJ76570 complete cds, highly similar to Homo sapiens small nuclear RNA activating complex, polypeptide 5, 19kDa, mRNA. BC014315 - Homo sapiens small nuclear RNA activating complex, polypeptide 5, 19kDa, mRNA (cDNA clone MGC:22700 IMAGE:3997264), complete cds. DQ583071 - Homo sapiens piRNA piR-50183, complete sequence. AF093593 - Homo sapiens snRNA activating protein complex 19kDa subunit (SNAP19) mRNA, complete cds. AK312018 - Homo sapiens cDNA, FLJ92293. KJ904649 - Synthetic construct Homo sapiens clone ccsbBroadEn_14043 SNAPC5 gene, encodes complete protein. AB464224 - Synthetic construct DNA, clone: pF1KB7505, Homo sapiens SNAPC5 gene for small nuclear RNA activating complex, polypeptide 5, 19kDa, without stop codon, in Flexi system. LF377480 - JP 2014500723-A/184983: Polycomb-Associated Non-Coding RNAs. MA620134 - JP 2018138019-A/192060: Polycomb-Associated Non-Coding RNAs. MA613057 - JP 2018138019-A/184983: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O75971 (Reactome details) participates in the following event(s):
R-HSA-83791 Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter R-HSA-6810239 SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) R-HSA-83793 Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex R-HSA-112054 RNA Polymerase III Abortive Initiation At Type 3 Open Promoters R-HSA-112156 RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters R-HSA-112152 RNA Polymerase III Promoter Opening at Type 3 Promoters R-HSA-6810234 General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene R-HSA-83803 Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex R-HSA-6810233 CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter R-HSA-6810238 RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) R-HSA-6810235 RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain R-HSA-6814885 CBCAP complex binds 7-methylguanosine cap of snRNA R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-6807505 RNA polymerase II transcribes snRNA genes R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation R-HSA-76046 RNA Polymerase III Transcription Initiation R-HSA-73857 RNA Polymerase II Transcription R-HSA-74158 RNA Polymerase III Transcription R-HSA-74160 Gene expression (Transcription)
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
