Human Gene SNRK (ENST00000296088.12_4) from GENCODE V47lift37
  Description: SNF related kinase, transcript variant 1 (from RefSeq NM_017719.5)
Gencode Transcript: ENST00000296088.12_4
Gencode Gene: ENSG00000163788.14_7
Transcript (Including UTRs)
   Position: hg19 chr3:43,328,032-43,392,635 Size: 64,604 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr3:43,344,696-43,390,049 Size: 45,354 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:43,328,032-43,392,635)mRNA (may differ from genome)Protein (765 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SNRK_HUMAN
DESCRIPTION: RecName: Full=SNF-related serine/threonine-protein kinase; EC=2.7.11.1; AltName: Full=SNF1-related kinase;
FUNCTION: May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Magnesium.
ENZYME REGULATION: Activated by phosphorylation on Thr-173.
SUBCELLULAR LOCATION: Nucleus (By similarity).
TISSUE SPECIFICITY: Expressed in hematopoietic progenitor cells and leukemic cell lines. Weakly expressed in the testis.
PTM: Autophosphorylated. Phosphorylation on Thr-173 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.
SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
SIMILARITY: Contains 1 protein kinase domain.
SIMILARITY: Contains 1 UBA domain.
SEQUENCE CAUTION: Sequence=BAA07744.2; Type=Erroneous initiation; Sequence=CAH18415.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.82 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 492.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -102.20304-0.336 Picture PostScript Text
3' UTR -667.402586-0.258 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS
IPR015940 - UBA/transl_elong_EF1B_N_euk

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine and serine/threonine kinase
PF14531 - Kinase-like

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on Q9NRH2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
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 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding

Biological Process:
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation
GO:0030099 myeloid cell differentiation
GO:0035556 intracellular signal transduction

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK291360 - Homo sapiens cDNA FLJ77864 complete cds, highly similar to Homo sapiens HSNFRK (HSNFRK) mRNA.
LF208679 - JP 2014500723-A/16182: Polycomb-Associated Non-Coding RNAs.
BC071567 - Homo sapiens SNF related kinase, mRNA (cDNA clone MGC:87067 IMAGE:4375623), complete cds.
AK295187 - Homo sapiens cDNA FLJ59517 complete cds, highly similar to SNF-related serine/threonine-protein kinase (EC 2.7.11.1).
CR749621 - Homo sapiens mRNA; cDNA DKFZp779A1866 (from clone DKFZp779A1866).
AF226044 - Homo sapiens HSNFRK (HSNFRK) mRNA, complete cds.
AK314376 - Homo sapiens cDNA, FLJ95149, highly similar to Homo sapiens SNF-1 related kinase (SNRK), mRNA.
D43636 - Homo sapiens mRNA for KIAA0096 gene.
AB383747 - Synthetic construct DNA, clone: pF1KSDA0096, Homo sapiens SNRK gene for SNF-related serine/threonine-protein kinase, complete cds, without stop codon, in Flexi system.
KJ899030 - Synthetic construct Homo sapiens clone ccsbBroadEn_08424 SNRK gene, encodes complete protein.
MA444256 - JP 2018138019-A/16182: Polycomb-Associated Non-Coding RNAs.
JD211214 - Sequence 192238 from Patent EP1572962.
AK000231 - Homo sapiens cDNA FLJ20224 fis, clone COLF5039.
U57452 - Human SNF1-like protein kinase mRNA, partial cds.
AK098414 - Homo sapiens cDNA FLJ25548 fis, clone JTH01554.
AK097949 - Homo sapiens cDNA FLJ40630 fis, clone THYMU2014327, highly similar to Homo sapiens HSNFRK (HSNFRK) mRNA.
AK025449 - Homo sapiens cDNA: FLJ21796 fis, clone HEP00537.
JD104101 - Sequence 85125 from Patent EP1572962.
JD270120 - Sequence 251144 from Patent EP1572962.
JD492947 - Sequence 473971 from Patent EP1572962.
JD251805 - Sequence 232829 from Patent EP1572962.
JD236323 - Sequence 217347 from Patent EP1572962.
JD531225 - Sequence 512249 from Patent EP1572962.
JD509867 - Sequence 490891 from Patent EP1572962.
JD550723 - Sequence 531747 from Patent EP1572962.
JD152850 - Sequence 133874 from Patent EP1572962.
JD296316 - Sequence 277340 from Patent EP1572962.
JD166051 - Sequence 147075 from Patent EP1572962.
JD192180 - Sequence 173204 from Patent EP1572962.
JD396756 - Sequence 377780 from Patent EP1572962.
JD527739 - Sequence 508763 from Patent EP1572962.
JD076709 - Sequence 57733 from Patent EP1572962.
AK026013 - Homo sapiens cDNA: FLJ22360 fis, clone HRC06511.
JD250398 - Sequence 231422 from Patent EP1572962.
JD110162 - Sequence 91186 from Patent EP1572962.
JD528641 - Sequence 509665 from Patent EP1572962.
JD260429 - Sequence 241453 from Patent EP1572962.
JD551205 - Sequence 532229 from Patent EP1572962.
JD052503 - Sequence 33527 from Patent EP1572962.
JD502362 - Sequence 483386 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RAV6, ENST00000296088.1, ENST00000296088.10, ENST00000296088.11, ENST00000296088.2, ENST00000296088.3, ENST00000296088.4, ENST00000296088.5, ENST00000296088.6, ENST00000296088.7, ENST00000296088.8, ENST00000296088.9, KIAA0096 , NM_017719, Q14706, Q68D15, Q6IQ46, Q9NRH2, Q9NXI7, SNFRK , SNRK , SNRK_HUMAN, uc317lqw.1, uc317lqw.2
UCSC ID: ENST00000296088.12_4
RefSeq Accession: NM_017719.5
Protein: Q9NRH2 (aka SNRK_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.