ID:SMD1_HUMAN DESCRIPTION: RecName: Full=Small nuclear ribonucleoprotein Sm D1; Short=Sm-D1; AltName: Full=Sm-D autoantigen; AltName: Full=snRNP core protein D1; FUNCTION: May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA. SUBUNIT: Identified in the spliceosome C complex. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. INTERACTION: P54105:CLNS1A; NbExp=5; IntAct=EBI-372177, EBI-724693; SUBCELLULAR LOCATION: Nucleus. PTM: Methylated on arginine residues by PRMT5 and PRMT7; methylation is required for assembly and biogenesis of snRNPs. MISCELLANEOUS: In the autoimmune disease systemic lupus erythematosus, antinuclear antibodies are developed with Sm specificity. SIMILARITY: Belongs to the snRNP core protein family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P62314
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KJ897589 - Synthetic construct Homo sapiens clone ccsbBroadEn_06983 SNRPD1 gene, encodes complete protein. J03798 - Human autoantigen small nuclear ribonucleoprotein Sm-D mRNA, complete cds. LF385232 - JP 2014500723-A/192735: Polycomb-Associated Non-Coding RNAs. BC001721 - Homo sapiens small nuclear ribonucleoprotein D1 polypeptide 16kDa, mRNA (cDNA clone MGC:2222 IMAGE:3355716), complete cds. AJ577268 - Homo sapiens mRNA for small nuclear ribonucleoprotein Sm D1 (SNRPD1 gene), mutated allele. BC072427 - Homo sapiens small nuclear ribonucleoprotein D1 polypeptide 16kDa, mRNA (cDNA clone MGC:87720 IMAGE:6464946), complete cds. LF342697 - JP 2014500723-A/150200: Polycomb-Associated Non-Coding RNAs. AB451350 - Homo sapiens SNRPD1 mRNA for small nuclear ribonucleoprotein D1 polypeptide 16kDa, partial cds, clone: FLJ08014AAAF. AB464217 - Synthetic construct DNA, clone: pF1KB6779, Homo sapiens SNRPD1 gene for small nuclear ribonucleoprotein D1 polypeptide, without stop codon, in Flexi system. CR542239 - Homo sapiens full open reading frame cDNA clone RZPDo834F1125D for gene SNRPD1, small nuclear ribonucleoprotein D1 polypeptide 16kDa; complete cds, without stopcodon. AB451227 - Homo sapiens SNRPD1 mRNA for small nuclear ribonucleoprotein D1 polypeptide 16kDa, complete cds, clone: FLJ08014AAAN. JD345891 - Sequence 326915 from Patent EP1572962. JD495811 - Sequence 476835 from Patent EP1572962. JD499049 - Sequence 480073 from Patent EP1572962. JD171388 - Sequence 152412 from Patent EP1572962. JD145340 - Sequence 126364 from Patent EP1572962. JD353735 - Sequence 334759 from Patent EP1572962. JD446396 - Sequence 427420 from Patent EP1572962. JD488588 - Sequence 469612 from Patent EP1572962. JD059738 - Sequence 40762 from Patent EP1572962. JD534843 - Sequence 515867 from Patent EP1572962. JD366563 - Sequence 347587 from Patent EP1572962. JD149425 - Sequence 130449 from Patent EP1572962. JD517738 - Sequence 498762 from Patent EP1572962. JD519139 - Sequence 500163 from Patent EP1572962. JD180066 - Sequence 161090 from Patent EP1572962. JD496208 - Sequence 477232 from Patent EP1572962. JD181008 - Sequence 162032 from Patent EP1572962. JD135979 - Sequence 117003 from Patent EP1572962. JD514984 - Sequence 496008 from Patent EP1572962. JD169871 - Sequence 150895 from Patent EP1572962. JD169873 - Sequence 150897 from Patent EP1572962. JD356386 - Sequence 337410 from Patent EP1572962. JD356385 - Sequence 337409 from Patent EP1572962. MA620809 - JP 2018138019-A/192735: Polycomb-Associated Non-Coding RNAs. MA578274 - JP 2018138019-A/150200: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_smPathway - Spliceosomal Assembly
Reactome (by CSHL, EBI, and GO)
Protein P62314 (Reactome details) participates in the following event(s):
R-HSA-191790 Loading and methylation of Sm proteins onto SMN Complexes R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-72107 Formation of the Spliceosomal E complex R-HSA-75083 ATAC spliceosome mediated 3' splice site cleavage, exon ligation R-HSA-75080 Formation of AT-AC A complex R-HSA-75079 Formation of AT-AC C complex R-HSA-191830 snRNP nuclear import and release R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-191786 snRNP complex assembly R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-75081 Formation of AT-AC B Complex R-HSA-75082 ATAC spliceosome mediated Lariat formation,5' splice site cleavage R-HSA-156661 Formation of Exon Junction Complex R-HSA-191763 snRNP:Snurportin complex formation R-HSA-191784 snRNA Cap hypermethylation R-HSA-191859 snRNP Assembly R-HSA-194441 Metabolism of non-coding RNA R-HSA-8953854 Metabolism of RNA R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72165 mRNA Splicing - Minor Pathway R-HSA-72172 mRNA Splicing R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
