ID:SMD2_HUMAN DESCRIPTION: RecName: Full=Small nuclear ribonucleoprotein Sm D2; Short=Sm-D2; AltName: Full=snRNP core protein D2; FUNCTION: Required for pre-mRNA splicing. Required for snRNP biogenesis (By similarity). SUBUNIT: Identified in the spliceosome C complex. composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. SUBCELLULAR LOCATION: Nucleus. MISCELLANEOUS: In the autoimmune disease systemic lupus erythematosus, antinuclear antibodies are developed with Sm specificity. SIMILARITY: Belongs to the snRNP core protein family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P62316
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK291912 - Homo sapiens cDNA FLJ76568 complete cds, highly similar to Homo sapiens small nuclear ribonucleoprotein D2 polypeptide 16.5kDa (SNRPD2), transcript variant 1, mRNA. BC001930 - Homo sapiens small nuclear ribonucleoprotein D2 polypeptide 16.5kDa, mRNA (cDNA clone MGC:3995 IMAGE:2819767), complete cds. BC000486 - Homo sapiens small nuclear ribonucleoprotein D2 polypeptide 16.5kDa, mRNA (cDNA clone MGC:8353 IMAGE:2819767), complete cds. U15008 - Human SnRNP core protein Sm D2 mRNA, complete cds. DQ891246 - Synthetic construct clone IMAGE:100003876; FLH176228.01X; RZPDo839A12122D small nuclear ribonucleoprotein D2 polypeptide 16.5kDa (SNRPD2) gene, encodes complete protein. KJ892177 - Synthetic construct Homo sapiens clone ccsbBroadEn_01571 SNRPD2 gene, encodes complete protein. DQ894432 - Synthetic construct Homo sapiens clone IMAGE:100008892; FLH176224.01L; RZPDo839A12121D small nuclear ribonucleoprotein D2 polypeptide 16.5kDa (SNRPD2) gene, encodes complete protein. AB464218 - Synthetic construct DNA, clone: pF1KB6775, Homo sapiens SNRPD2 gene for small nuclear ribonucleoprotein D2 polypeptide, without stop codon, in Flexi system. JD438018 - Sequence 419042 from Patent EP1572962. JD185179 - Sequence 166203 from Patent EP1572962. JD147545 - Sequence 128569 from Patent EP1572962. JD418799 - Sequence 399823 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_smPathway - Spliceosomal Assembly
Reactome (by CSHL, EBI, and GO)
Protein P62316 (Reactome details) participates in the following event(s):
R-HSA-191790 Loading and methylation of Sm proteins onto SMN Complexes R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-72107 Formation of the Spliceosomal E complex R-HSA-75083 ATAC spliceosome mediated 3' splice site cleavage, exon ligation R-HSA-75080 Formation of AT-AC A complex R-HSA-75079 Formation of AT-AC C complex R-HSA-191830 snRNP nuclear import and release R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-191786 snRNP complex assembly R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-75081 Formation of AT-AC B Complex R-HSA-75082 ATAC spliceosome mediated Lariat formation,5' splice site cleavage R-HSA-156661 Formation of Exon Junction Complex R-HSA-191763 snRNP:Snurportin complex formation R-HSA-191784 snRNA Cap hypermethylation R-HSA-191859 snRNP Assembly R-HSA-194441 Metabolism of non-coding RNA R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72165 mRNA Splicing - Minor Pathway R-HSA-8953854 Metabolism of RNA R-HSA-72172 mRNA Splicing R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
