ID:RUXE_HUMAN DESCRIPTION: RecName: Full=Small nuclear ribonucleoprotein E; Short=snRNP-E; AltName: Full=Sm protein E; Short=Sm-E; Short=SmE; FUNCTION: Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Associated with snRNP U1, U2, U4/U6 and U5. SUBUNIT: Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10 and LSM11 proteins. Identified in the spliceosome C complex. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. INTERACTION: Q8TEQ6:GEMIN5; NbExp=2; IntAct=EBI-348082, EBI-443630; SUBCELLULAR LOCATION: Nucleus. MISCELLANEOUS: Patients with systemic lupus erythematosus produce antibodies which interact with snRNP proteins. SIMILARITY: Belongs to the snRNP Sm proteins family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P62304
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF205351 - JP 2014500723-A/12854: Polycomb-Associated Non-Coding RNAs. D28435 - Homo sapiens mRNA for U1/U2 snRNP E, 5'UTR region. AK307255 - Homo sapiens cDNA, FLJ97203. LF213697 - JP 2014500723-A/21200: Polycomb-Associated Non-Coding RNAs. AK309140 - Homo sapiens cDNA, FLJ99181. AK312130 - Homo sapiens cDNA, FLJ92412, Homo sapiens small nuclear ribonucleoprotein polypeptide E (SNRPE),mRNA. BC090951 - Homo sapiens small nuclear ribonucleoprotein polypeptide E, mRNA (cDNA clone MGC:105067 IMAGE:5204266), complete cds. M37716 - Human small nuclear RNA protein E mRNA, complete cds. X12466 - Human mRNA for snRNP E protein. BC002639 - Homo sapiens small nuclear ribonucleoprotein polypeptide E, mRNA (cDNA clone MGC:3652 IMAGE:3609230), complete cds. S60260 - B-raf=activated oncogene {rearranged 5' region, transfected DNA} [human, transformed NIH3T3 cells, mRNA Partial, 342 nt]. JD233100 - Sequence 214124 from Patent EP1572962. BC072433 - Homo sapiens small nuclear ribonucleoprotein polypeptide E, mRNA (cDNA clone IMAGE:5727660). AB464220 - Synthetic construct DNA, clone: pF1KB6729, Homo sapiens SNRPE gene for small nuclear ribonucleoprotein polypeptide E, without stop codon, in Flexi system. KJ892178 - Synthetic construct Homo sapiens clone ccsbBroadEn_01572 SNRPE gene, encodes complete protein. M15919 - Human autoimmune antigen small nuclear ribonucleoprotein E mRNA. LF319545 - JP 2014500723-A/127048: Polycomb-Associated Non-Coding RNAs. LF319543 - JP 2014500723-A/127046: Polycomb-Associated Non-Coding RNAs. LF365996 - JP 2014500723-A/173499: Polycomb-Associated Non-Coding RNAs. LF319541 - JP 2014500723-A/127044: Polycomb-Associated Non-Coding RNAs. JD019241 - Sequence 265 from Patent EP1572962. LF319540 - JP 2014500723-A/127043: Polycomb-Associated Non-Coding RNAs. JD027883 - Sequence 8907 from Patent EP1572962. LF319539 - JP 2014500723-A/127042: Polycomb-Associated Non-Coding RNAs. MA601573 - JP 2018138019-A/173499: Polycomb-Associated Non-Coding RNAs. MA440928 - JP 2018138019-A/12854: Polycomb-Associated Non-Coding RNAs. MA449274 - JP 2018138019-A/21200: Polycomb-Associated Non-Coding RNAs. MA555122 - JP 2018138019-A/127048: Polycomb-Associated Non-Coding RNAs. MA555120 - JP 2018138019-A/127046: Polycomb-Associated Non-Coding RNAs. MA555118 - JP 2018138019-A/127044: Polycomb-Associated Non-Coding RNAs. MA555117 - JP 2018138019-A/127043: Polycomb-Associated Non-Coding RNAs. MA555116 - JP 2018138019-A/127042: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_smPathway - Spliceosomal Assembly
Reactome (by CSHL, EBI, and GO)
Protein P62304 (Reactome details) participates in the following event(s):
R-HSA-191790 Loading and methylation of Sm proteins onto SMN Complexes R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-72107 Formation of the Spliceosomal E complex R-HSA-75083 ATAC spliceosome mediated 3' splice site cleavage, exon ligation R-HSA-75080 Formation of AT-AC A complex R-HSA-75079 Formation of AT-AC C complex R-HSA-191830 snRNP nuclear import and release R-HSA-77585 Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA R-HSA-111438 Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA R-HSA-77586 Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA R-HSA-111437 Cleavage of the 3'-end of the Histone Pre-mRNA R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-191786 snRNP complex assembly R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-75081 Formation of AT-AC B Complex R-HSA-75082 ATAC spliceosome mediated Lariat formation,5' splice site cleavage R-HSA-156661 Formation of Exon Junction Complex R-HSA-191763 snRNP:Snurportin complex formation R-HSA-191784 snRNA Cap hypermethylation R-HSA-191859 snRNP Assembly R-HSA-194441 Metabolism of non-coding RNA R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72165 mRNA Splicing - Minor Pathway R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-8953854 Metabolism of RNA R-HSA-72172 mRNA Splicing R-HSA-75067 Processing of Capped Intronless Pre-mRNA R-HSA-73856 RNA Polymerase II Transcription Termination R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
