Human Gene SNX24 (ENST00000261369.9_4) from GENCODE V47lift37
  Description: sorting nexin 24, transcript variant 2 (from RefSeq NR_146145.2)
Gencode Transcript: ENST00000261369.9_4
Gencode Gene: ENSG00000064652.11_9
Transcript (Including UTRs)
   Position: hg19 chr5:122,181,308-122,344,900 Size: 163,593 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr5:122,181,329-122,343,444 Size: 162,116 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:122,181,308-122,344,900)mRNA (may differ from genome)Protein (169 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SNX24_HUMAN
DESCRIPTION: RecName: Full=Sorting nexin-24;
FUNCTION: May be involved in several stages of intracellular trafficking (By similarity).
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity).
DOMAIN: The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).
SIMILARITY: Belongs to the sorting nexin family.
SIMILARITY: Contains 1 PX (phox homology) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.80 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 191.24 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -9.8021-0.467 Picture PostScript Text
3' UTR -365.401456-0.251 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001683 - Phox

Pfam Domains:
PF00787 - PX domain

SCOP Domains:
64268 - PX domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
4AZ9 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q9Y343
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008289 lipid binding
GO:0010314 phosphatidylinositol-5-phosphate binding
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0035091 phosphatidylinositol binding
GO:0070273 phosphatidylinositol-4-phosphate binding

Biological Process:
GO:0015031 protein transport

Cellular Component:
GO:0016020 membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle


-  Descriptions from all associated GenBank mRNAs
  BC010886 - Homo sapiens sorting nexin 24, mRNA (cDNA clone MGC:745 IMAGE:3538426), complete cds.
BC069012 - Homo sapiens sorting nexin 24, mRNA (cDNA clone MGC:78539 IMAGE:4585781), complete cds.
AF139461 - Homo sapiens hypothetical protein SBBI31 mRNA, complete cds.
AY358098 - Homo sapiens clone DNA66477 SBBI31 (UNQ654) mRNA, complete cds.
CU679837 - Synthetic construct Homo sapiens gateway clone IMAGE:100020747 5' read SNX24 mRNA.
CU686699 - Synthetic construct Homo sapiens gateway clone IMAGE:100023051 5' read SNX24 mRNA.
HQ448039 - Synthetic construct Homo sapiens clone IMAGE:100071414; CCSB005986_03 sorting nexing 24 (SNX24) gene, encodes complete protein.
KJ893652 - Synthetic construct Homo sapiens clone ccsbBroadEn_03046 SNX24 gene, encodes complete protein.
KJ902494 - Synthetic construct Homo sapiens clone ccsbBroadEn_11888 SNX24 gene, encodes complete protein.
AY044655 - Homo sapiens sorting nexin SNX24 (SNX24) mRNA, complete cds.
AK021473 - Homo sapiens cDNA FLJ11411 fis, clone HEMBA1000870.
JD086335 - Sequence 67359 from Patent EP1572962.
JD377241 - Sequence 358265 from Patent EP1572962.
JD434121 - Sequence 415145 from Patent EP1572962.
JD164558 - Sequence 145582 from Patent EP1572962.
JD239340 - Sequence 220364 from Patent EP1572962.
JD364846 - Sequence 345870 from Patent EP1572962.
JD189125 - Sequence 170149 from Patent EP1572962.
JD136013 - Sequence 117037 from Patent EP1572962.
JD104631 - Sequence 85655 from Patent EP1572962.
JD419921 - Sequence 400945 from Patent EP1572962.
JD223077 - Sequence 204101 from Patent EP1572962.
JD349630 - Sequence 330654 from Patent EP1572962.
JD309803 - Sequence 290827 from Patent EP1572962.
JD058888 - Sequence 39912 from Patent EP1572962.
JD551372 - Sequence 532396 from Patent EP1572962.
JD147390 - Sequence 128414 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000261369.1, ENST00000261369.2, ENST00000261369.3, ENST00000261369.4, ENST00000261369.5, ENST00000261369.6, ENST00000261369.7, ENST00000261369.8, NR_146145, Q6UY33, Q9Y343, SBBI31, SNX24_HUMAN, uc317gpe.1, uc317gpe.2, UNQ654/PRO1284
UCSC ID: ENST00000261369.9_4
RefSeq Accession: NM_014035.4
Protein: Q9Y343 (aka SNX24_HUMAN or SNXO_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.