Human Gene SOCS2 (ENST00000551556.2_4) from GENCODE V47lift37
  Description: suppressor of cytokine signaling 2, transcript variant 6 (from RefSeq NM_001270471.2)
Gencode Transcript: ENST00000551556.2_4
Gencode Gene: ENSG00000120833.14_14
Transcript (Including UTRs)
   Position: hg19 chr12:93,966,451-93,970,521 Size: 4,071 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr12:93,966,674-93,968,955 Size: 2,282 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:93,966,451-93,970,521)mRNA (may differ from genome)Protein (198 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SOCS2_HUMAN
DESCRIPTION: RecName: Full=Suppressor of cytokine signaling 2; Short=SOCS-2; AltName: Full=Cytokine-inducible SH2 protein 2; Short=CIS-2; AltName: Full=STAT-induced STAT inhibitor 2; Short=SSI-2;
FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
PATHWAY: Protein modification; protein ubiquitination.
SUBUNIT: Interacts with IGF1 receptor, prolactin receptor and growth hormone (GH) receptor. Associates with the Elongin BC complex.
INTERACTION: P19235:EPOR; NbExp=3; IntAct=EBI-617737, EBI-617321;
TISSUE SPECIFICITY: High expression in heart, placenta, lung, kidney and prostate.
INDUCTION: By a subset of cytokines, including EPO/erythropoietin and CSF2/GM-CSF.
DOMAIN: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
SIMILARITY: Contains 1 SH2 domain.
SIMILARITY: Contains 1 SOCS box domain.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/SOCS2ID44123ch12q21.html";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SOCS2
Diseases sorted by gene-association score: essential thrombocythemia (2), vertebral artery occlusion (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 24.02 RPKM in Cervix - Ectocervix
Total median expression: 260.84 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -76.30223-0.342 Picture PostScript Text
3' UTR -372.901566-0.238 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000980 - SH2
IPR001496 - SOCS_C

Pfam Domains:
PF00017 - SH2 domain
PF07525 - SOCS box

SCOP Domains:
158235 - SOCS box-like
55550 - SH2 domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2C9W - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on O14508
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004860 protein kinase inhibitor activity
GO:0005070 SH3/SH2 adaptor activity
GO:0005131 growth hormone receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005515 protein binding
GO:0008269 JAK pathway signal transduction adaptor activity

Biological Process:
GO:0001558 regulation of cell growth
GO:0006469 negative regulation of protein kinase activity
GO:0007259 JAK-STAT cascade
GO:0007595 lactation
GO:0009966 regulation of signal transduction
GO:0009967 positive regulation of signal transduction
GO:0009968 negative regulation of signal transduction
GO:0016567 protein ubiquitination
GO:0019221 cytokine-mediated signaling pathway
GO:0032355 response to estradiol
GO:0032870 cellular response to hormone stimulus
GO:0035556 intracellular signal transduction
GO:0038111 interleukin-7-mediated signaling pathway
GO:0040008 regulation of growth
GO:0040014 regulation of multicellular organism growth
GO:0040015 negative regulation of multicellular organism growth
GO:0043066 negative regulation of apoptotic process
GO:0043687 post-translational protein modification
GO:0045666 positive regulation of neuron differentiation
GO:0046426 negative regulation of JAK-STAT cascade
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0060396 growth hormone receptor signaling pathway
GO:0060749 mammary gland alveolus development

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AK313165 - Homo sapiens cDNA, FLJ93661, Homo sapiens suppressor of cytokine signaling 2 (SOCS2), mRNA.
AK297662 - Homo sapiens cDNA FLJ52461 complete cds, highly similar to Suppressor of cytokine signaling 2.
AK309452 - Homo sapiens cDNA, FLJ99493.
BC070039 - Homo sapiens suppressor of cytokine signaling 2, mRNA (cDNA clone IMAGE:30346134).
AK290546 - Homo sapiens cDNA FLJ78547 complete cds, highly similar to Homo sapiens suppressor of cytokine signaling 2 (SOCS2), mRNA.
AF037989 - Homo sapiens STAT-induced STAT inhibitor-2 mRNA, complete cds.
AF020590 - Homo sapiens suppressor of cytokine signalling-2 (HSSOCS-2) mRNA, complete cds.
BC010399 - Homo sapiens suppressor of cytokine signaling 2, mRNA (cDNA clone MGC:13697 IMAGE:4277425), complete cds.
JD111634 - Sequence 92658 from Patent EP1572962.
JD043666 - Sequence 24690 from Patent EP1572962.
JD190828 - Sequence 171852 from Patent EP1572962.
JD437350 - Sequence 418374 from Patent EP1572962.
LF209493 - JP 2014500723-A/16996: Polycomb-Associated Non-Coding RNAs.
AB004903 - Homo sapiens mRNA for STAT induced STAT inhibitor-2, complete cds.
JD129658 - Sequence 110682 from Patent EP1572962.
CU679697 - Synthetic construct Homo sapiens gateway clone IMAGE:100017571 5' read SOCS2 mRNA.
AB587527 - Synthetic construct DNA, clone: pF1KE0629, Homo sapiens SOCS2 gene for suppressor of cytokine signaling 2, without stop codon, in Flexi system.
KJ892634 - Synthetic construct Homo sapiens clone ccsbBroadEn_02028 SOCS2 gene, encodes complete protein.
AB006966 - Homo sapiens mRNA for CIS2, complete cds.
AB451318 - Homo sapiens SOCS2 mRNA for suppressor of cytokine signaling-2, complete cds, clone: FLJ08186AAAN.
LF328904 - JP 2014500723-A/136407: Polycomb-Associated Non-Coding RNAs.
LF328905 - JP 2014500723-A/136408: Polycomb-Associated Non-Coding RNAs.
LF328906 - JP 2014500723-A/136409: Polycomb-Associated Non-Coding RNAs.
LF328907 - JP 2014500723-A/136410: Polycomb-Associated Non-Coding RNAs.
JD518507 - Sequence 499531 from Patent EP1572962.
JD440107 - Sequence 421131 from Patent EP1572962.
JD214604 - Sequence 195628 from Patent EP1572962.
JD311162 - Sequence 292186 from Patent EP1572962.
JD098541 - Sequence 79565 from Patent EP1572962.
JD107255 - Sequence 88279 from Patent EP1572962.
JD476556 - Sequence 457580 from Patent EP1572962.
JD491478 - Sequence 472502 from Patent EP1572962.
JD043430 - Sequence 24454 from Patent EP1572962.
JD289612 - Sequence 270636 from Patent EP1572962.
JD283569 - Sequence 264593 from Patent EP1572962.
JD315777 - Sequence 296801 from Patent EP1572962.
MA564481 - JP 2018138019-A/136407: Polycomb-Associated Non-Coding RNAs.
MA564482 - JP 2018138019-A/136408: Polycomb-Associated Non-Coding RNAs.
MA564483 - JP 2018138019-A/136409: Polycomb-Associated Non-Coding RNAs.
MA564484 - JP 2018138019-A/136410: Polycomb-Associated Non-Coding RNAs.
MA445070 - JP 2018138019-A/16996: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O14508 (Reactome details) participates in the following event(s):

R-HSA-1168809 SOCS binding to GHR
R-NUL-1169195 SOCS binding to Ghr
R-HSA-1168813 SOCS binding to JAK2
R-HSA-8952039 NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex
R-HSA-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases
R-HSA-8952044 AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex
R-HSA-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes
R-HSA-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes
R-HSA-982772 Growth hormone receptor signaling
R-HSA-1266695 Interleukin-7 signaling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-449147 Signaling by Interleukins
R-HSA-168256 Immune System
R-HSA-8951664 Neddylation
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: A8K3D1, CIS2, ENST00000551556.1, NM_001270471, O14508, O14542, O95102, Q9UKS5, SOCS2_HUMAN, SSI2, STATI2, uc325cnr.1, uc325cnr.2
UCSC ID: ENST00000551556.2_4
RefSeq Accession: NM_001270471.2
Protein: O14508 (aka SOCS2_HUMAN or SOC2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.