Human Gene SOCS3 (ENST00000330871.3_7) from GENCODE V47lift37
  Description: suppressor of cytokine signaling 3, transcript variant 1 (from RefSeq NM_003955.5)
Gencode Transcript: ENST00000330871.3_7
Gencode Gene: ENSG00000184557.4_10
Transcript (Including UTRs)
   Position: hg19 chr17:76,352,859-76,356,158 Size: 3,300 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr17:76,354,499-76,355,176 Size: 678 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:76,352,859-76,356,158)mRNA (may differ from genome)Protein (225 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q6FI39_HUMAN
DESCRIPTION: SubName: Full=SOCS3 protein; SubName: Full=Suppressor of cytokine signaling 3, isoform CRA_a; SubName: Full=cDNA, FLJ94944, highly similar to Homo sapiens suppressor of cytokine signaling 3 (SOCS3), mRNA;
PATHWAY: Protein modification; protein ubiquitination.
SIMILARITY: Contains 1 SOCS box domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SOCS3
Diseases sorted by gene-association score: overnutrition (11), atopic dermatitis (11), infectious anterior uveitis (11), articulation disorder (7), primary polycythemia (7), hepatitis c (7), speech disorder (6), placental insufficiency (6), myeloproliferative neoplasm (6), prostatic acinar adenocarcinoma (5), polycythemia vera, somatic (5), dermatitis (4), essential thrombocythemia (2), obesity (2), diabetes mellitus, noninsulin-dependent (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 207.56 RPKM in Fallopian Tube
Total median expression: 1379.28 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -221.90416-0.533 Picture PostScript Text
3' UTR -630.401640-0.384 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000980 - SH2
IPR001496 - SOCS_C

Pfam Domains:
PF00017 - SH2 domain

SCOP Domains:
158235 - SOCS box-like
55550 - SH2 domain

ModBase Predicted Comparative 3D Structure on Q6FI39
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001784 phosphotyrosine binding

Biological Process:
GO:0001932 regulation of protein phosphorylation
GO:0007259 JAK-STAT cascade
GO:0009968 negative regulation of signal transduction
GO:0016567 protein ubiquitination
GO:0035556 intracellular signal transduction
GO:0043066 negative regulation of apoptotic process
GO:0045595 regulation of cell differentiation
GO:0045597 positive regulation of cell differentiation
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0050728 negative regulation of inflammatory response
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0060674 placenta blood vessel development
GO:0060707 trophoblast giant cell differentiation
GO:0060708 spongiotrophoblast differentiation
GO:1990830 cellular response to leukemia inhibitory factor

Cellular Component:
GO:0005622 intracellular


-  Descriptions from all associated GenBank mRNAs
  KJ892670 - Synthetic construct Homo sapiens clone ccsbBroadEn_02064 SOCS3 gene, encodes complete protein.
LF209433 - JP 2014500723-A/16936: Polycomb-Associated Non-Coding RNAs.
LF213997 - JP 2014500723-A/21500: Polycomb-Associated Non-Coding RNAs.
BC060858 - Homo sapiens suppressor of cytokine signaling 3, mRNA (cDNA clone MGC:71791 IMAGE:30333577), complete cds.
FW573283 - JP 2010529847-A/4: Oligonucleotides for modulation of target RNA activity.
LF328467 - JP 2014500723-A/135970: Polycomb-Associated Non-Coding RNAs.
LF328469 - JP 2014500723-A/135972: Polycomb-Associated Non-Coding RNAs.
LF328470 - JP 2014500723-A/135973: Polycomb-Associated Non-Coding RNAs.
LF328471 - JP 2014500723-A/135974: Polycomb-Associated Non-Coding RNAs.
LF328473 - JP 2014500723-A/135976: Polycomb-Associated Non-Coding RNAs.
LF328474 - JP 2014500723-A/135977: Polycomb-Associated Non-Coding RNAs.
JD097556 - Sequence 78580 from Patent EP1572962.
LF328477 - JP 2014500723-A/135980: Polycomb-Associated Non-Coding RNAs.
AK309756 - Homo sapiens cDNA, FLJ99797.
AB004904 - Homo sapiens mRNA for STAT induced STAT inhibitor-3, complete cds.
AF159854 - Homo sapiens cytokine signaling suppressor (SOCS3) mRNA, complete cds.
AB006967 - Homo sapiens mRNA for CIS3, complete cds.
CR536497 - Homo sapiens full open reading frame cDNA clone RZPDo834F1117D for gene SOCS3, suppressor of cytokine signaling 3; complete cds, incl. stopcodon.
AK314212 - Homo sapiens cDNA, FLJ94944, highly similar to Homo sapiens suppressor of cytokine signaling 3 (SOCS3), mRNA.
BT019544 - Homo sapiens suppressor of cytokine signaling 3 mRNA, complete cds.
CU687476 - Synthetic construct Homo sapiens gateway clone IMAGE:100020848 5' read SOCS3 mRNA.
AM392896 - Synthetic construct Homo sapiens clone IMAGE:100002708 for hypothetical protein (SOCS3 gene).
AM393146 - Synthetic construct Homo sapiens clone IMAGE:100002957 for hypothetical protein (SOCS3 gene).
AM393491 - Synthetic construct Homo sapiens clone IMAGE:100002709 for hypothetical protein (SOCS3 gene).
CR541694 - Homo sapiens full open reading frame cDNA clone RZPDo834G0128D for gene SOCS3, suppressor of cytokine signaling 3; complete cds, without stopcodon.
AB464720 - Synthetic construct DNA, clone: pF1KB8767, Homo sapiens SOCS3 gene for suppressor of cytokine signaling 3, without stop codon, in Flexi system.
LF328479 - JP 2014500723-A/135982: Polycomb-Associated Non-Coding RNAs.
JD456188 - Sequence 437212 from Patent EP1572962.
JD187628 - Sequence 168652 from Patent EP1572962.
JD142392 - Sequence 123416 from Patent EP1572962.
MA449574 - JP 2018138019-A/21500: Polycomb-Associated Non-Coding RNAs.
MA564044 - JP 2018138019-A/135970: Polycomb-Associated Non-Coding RNAs.
MA564046 - JP 2018138019-A/135972: Polycomb-Associated Non-Coding RNAs.
MA564047 - JP 2018138019-A/135973: Polycomb-Associated Non-Coding RNAs.
MA564048 - JP 2018138019-A/135974: Polycomb-Associated Non-Coding RNAs.
MA564050 - JP 2018138019-A/135976: Polycomb-Associated Non-Coding RNAs.
MA564051 - JP 2018138019-A/135977: Polycomb-Associated Non-Coding RNAs.
MA564054 - JP 2018138019-A/135980: Polycomb-Associated Non-Coding RNAs.
MA564056 - JP 2018138019-A/135982: Polycomb-Associated Non-Coding RNAs.
MA445010 - JP 2018138019-A/16936: Polycomb-Associated Non-Coding RNAs.
MP067499 - Sequence 3 from Patent WO2018232288.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_il22bppathway - IL22 Soluble Receptor Signaling Pathway
h_il2rbPathway - IL-2 Receptor Beta Chain in T cell Activation

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000330871.1, ENST00000330871.2, hCG_1776363 , NM_003955, Q6FI39, Q6FI39_HUMAN, SOCS3 , uc317tbo.1, uc317tbo.2
UCSC ID: ENST00000330871.3_7
RefSeq Accession: NM_003955.5
Protein: Q6FI39

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.