ID:SODM_HUMAN DESCRIPTION: RecName: Full=Superoxide dismutase [Mn], mitochondrial; EC=1.15.1.1; Flags: Precursor; FUNCTION: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. CATALYTIC ACTIVITY: 2 superoxide + 2 H(+) = O(2) + H(2)O(2). COFACTOR: Binds 1 manganese ion per subunit. SUBUNIT: Homotetramer. SUBCELLULAR LOCATION: Mitochondrion matrix. INDUCTION: Expression is regulated by KRIT1. PTM: Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity. DISEASE: Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6) [MIM:612634]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new- onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. SIMILARITY: Belongs to the iron/manganese superoxide dismutase family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/sod2/"; WEB RESOURCE: Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=SOD2"; WEB RESOURCE: Name=Wikipedia; Note=Superoxide dismutase entry; URL="http://en.wikipedia.org/wiki/Superoxide_dismutase";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P04179
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000303 response to superoxide GO:0001315 age-dependent response to reactive oxygen species GO:0001836 release of cytochrome c from mitochondria GO:0003069 vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006801 superoxide metabolic process GO:0008217 regulation of blood pressure GO:0008285 negative regulation of cell proliferation GO:0019430 removal of superoxide radicals GO:0030335 positive regulation of cell migration GO:0032364 oxygen homeostasis GO:0034599 cellular response to oxidative stress GO:0035722 interleukin-12-mediated signaling pathway GO:0043524 negative regulation of neuron apoptotic process GO:0051289 protein homotetramerization GO:0055114 oxidation-reduction process GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1904706 negative regulation of vascular smooth muscle cell proliferation GO:1905461 positive regulation of vascular associated smooth muscle cell apoptotic process
BioCarta from NCI Cancer Genome Anatomy Project h_longevityPathway - The IGF-1 Receptor and Longevity h_eponfkbPathway - Erythropoietin mediated neuroprotection through NF-kB
Reactome (by CSHL, EBI, and GO)
Protein P04179 (Reactome details) participates in the following event(s):
R-HSA-5688289 SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 R-HSA-3299680 SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis R-HSA-8863678 Neurodegenerative Diseases R-HSA-9020591 Interleukin-12 signaling R-HSA-1592230 Mitochondrial biogenesis R-HSA-1643685 Disease R-HSA-447115 Interleukin-12 family signaling R-HSA-3299685 Detoxification of Reactive Oxygen Species R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-449147 Signaling by Interleukins R-HSA-2262752 Cellular responses to stress R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-8953897 Cellular responses to external stimuli R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
