ID:SOSD1_HUMAN DESCRIPTION: RecName: Full=Sclerostin domain-containing protein 1; AltName: Full=Ectodermal BMP inhibitor; Short=Ectodin; AltName: Full=Uterine sensitization-associated gene 1 protein; Short=USAG-1; Flags: Precursor; FUNCTION: May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner. SUBUNIT: Interacts with BMP2, BMP4, BMP6 and BMP7 with high affinity. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Highly expressed in kidney and weakly in lung. SIMILARITY: Belongs to the sclerostin family. SIMILARITY: Contains 1 CTCK (C-terminal cystine knot-like) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6X4U4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
