ID:SPRE1_HUMAN DESCRIPTION: RecName: Full=Sprouty-related, EVH1 domain-containing protein 1; Short=Spred-1; Short=hSpred1; FUNCTION: Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity). SUBUNIT: Interacts with Ras. Interacts with TAOK2 and TESK1 (By similarity). Homodimer and heterodimer. Interacts with CAV1. Able to interact with SPRED2 to form heterodimers. INTERACTION: P62136:PPP1CA; NbExp=3; IntAct=EBI-5235340, EBI-357253; SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Nucleus. Note=Localized in cholesterol-rich membrane raft/caveola fractions. TISSUE SPECIFICITY: Weakly expressed in embryonic cell line HEK293. PTM: Phosphorylated on tyrosine (By similarity). DISEASE: Defects in SPRED1 are the cause of neurofibromatosis type 1-like syndrome (NFLS) [MIM:611431]. It is a disorder characterized mainly by cafe au lait macules without neurofibromas or other tumor manifestations of neurofibromatosis type 1, axillary freckling, and macrocephaly. Additional clinical manifestations include Noonan-like facial dysmorphism, lipomas, learning disabilities and attention deficit-hyperactivity. SIMILARITY: Contains 1 KBD domain. SIMILARITY: Contains 1 SPR (sprouty) domain. SIMILARITY: Contains 1 WH1 domain. SEQUENCE CAUTION: Sequence=AAH18015.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7Z699
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005173 stem cell factor receptor binding GO:0005515 protein binding GO:0019901 protein kinase binding GO:0019902 phosphatase binding GO:0030291 protein serine/threonine kinase inhibitor activity
Biological Process: GO:0000165 MAPK cascade GO:0000188 inactivation of MAPK activity GO:0006469 negative regulation of protein kinase activity GO:0007275 multicellular organism development GO:0008543 fibroblast growth factor receptor signaling pathway GO:0009966 regulation of signal transduction GO:0010801 negative regulation of peptidyl-threonine phosphorylation GO:0010923 negative regulation of phosphatase activity GO:0016525 negative regulation of angiogenesis GO:0043408 regulation of MAPK cascade GO:0043409 negative regulation of MAPK cascade GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator GO:0060979 vasculogenesis involved in coronary vascular morphogenesis GO:0070373 negative regulation of ERK1 and ERK2 cascade GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis GO:0090311 regulation of protein deacetylation
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
