ID:SPTN5_HUMAN DESCRIPTION: RecName: Full=Spectrin beta chain, non-erythrocytic 5; AltName: Full=Beta-V spectrin; SUBUNIT: Probably associates with an alpha chain. Interacts (via C-terminus) with TRPC4. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Note=Detected prominently in the outer segments of photoreceptor rods and cones and in the basolateral membrane and cytosol of gastric epithelial cells. TISSUE SPECIFICITY: Expressed at very low levels in many tissues, with strongest expression in cerebellum, spinal cord, stomach, pituitary gland, liver, pancreas, salivary gland, kidney, bladder, and heart. SIMILARITY: Belongs to the spectrin family. SIMILARITY: Contains 2 CH (calponin-homology) domains. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 31 spectrin repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NRC6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AF233523 - Homo sapiens beta V spectrin (BSPECV) mRNA, complete cds. JD089803 - Sequence 70827 from Patent EP1572962. JD267818 - Sequence 248842 from Patent EP1572962. JD232968 - Sequence 213992 from Patent EP1572962. JD209561 - Sequence 190585 from Patent EP1572962. JD113509 - Sequence 94533 from Patent EP1572962. JD253342 - Sequence 234366 from Patent EP1572962. JD397630 - Sequence 378654 from Patent EP1572962. JD293851 - Sequence 274875 from Patent EP1572962. JD507134 - Sequence 488158 from Patent EP1572962. JD411265 - Sequence 392289 from Patent EP1572962. JD383133 - Sequence 364157 from Patent EP1572962. JD458637 - Sequence 439661 from Patent EP1572962. JD126895 - Sequence 107919 from Patent EP1572962. JD519360 - Sequence 500384 from Patent EP1572962. JD541559 - Sequence 522583 from Patent EP1572962. JD254972 - Sequence 235996 from Patent EP1572962. JD477139 - Sequence 458163 from Patent EP1572962. JD535402 - Sequence 516426 from Patent EP1572962. JD283249 - Sequence 264273 from Patent EP1572962. JD467410 - Sequence 448434 from Patent EP1572962. JD159727 - Sequence 140751 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9NRC6 (Reactome details) participates in the following event(s):
R-HSA-391868 Dephosphorylation of NCAM1 bound pFyn R-NUL-420388 Dephosphorylation of NCAM1 bound pFyn R-HSA-391865 Recruitment of FAK to NCAM1:Fyn in lipid rafts R-HSA-391871 Autophosphorylation of NCAM1 bound Fyn R-HSA-392751 L1 linked to actin cytoskeleton by ankyrin R-HSA-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex R-NUL-420398 Autophosphorylation of NCAM1 bound Fyn R-HSA-391866 Phosphorylation of FAK by Src kinase R-HSA-392051 Recruitment of Grb2 to pFAK:NCAM1 R-HSA-392053 SOS binds Grb2 bound to pFAK:NCAM1 R-HSA-373739 Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 R-HSA-6807877 ARFGAPs stimulate ARF GTPase activity R-HSA-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin R-HSA-392054 NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras R-HSA-6809006 Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex R-HSA-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle R-HSA-5672965 RAS GEFs promote RAS nucleotide exchange R-HSA-375165 NCAM signaling for neurite out-growth R-HSA-445095 Interaction between L1 and Ankyrins R-HSA-6807878 COPI-mediated anterograde transport R-HSA-422475 Axon guidance R-HSA-373760 L1CAM interactions R-HSA-199977 ER to Golgi Anterograde Transport R-HSA-1266738 Developmental Biology R-HSA-199991 Membrane Trafficking R-HSA-948021 Transport to the Golgi and subsequent modification R-HSA-5673001 RAF/MAP kinase cascade R-HSA-5653656 Vesicle-mediated transport R-HSA-446203 Asparagine N-linked glycosylation R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-597592 Post-translational protein modification R-HSA-5683057 MAPK family signaling cascades R-HSA-392499 Metabolism of proteins R-HSA-162582 Signal Transduction
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
