ID:SRBP1_HUMAN DESCRIPTION: RecName: Full=Sterol regulatory element-binding protein 1; Short=SREBP-1; AltName: Full=Class D basic helix-loop-helix protein 1; Short=bHLHd1; AltName: Full=Sterol regulatory element-binding transcription factor 1; Contains: RecName: Full=Processed sterol regulatory element-binding protein 1; FUNCTION: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). SUBUNIT: Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. INTERACTION: P45481:Crebbp (xeno); NbExp=2; IntAct=EBI-948328, EBI-296306; Q96RN5:MED15; NbExp=6; IntAct=EBI-948328, EBI-394506; Q96EB6:SIRT1; NbExp=2; IntAct=EBI-948338, EBI-1802965; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. SUBCELLULAR LOCATION: Processed sterol regulatory element-binding protein 1: Nucleus. TISSUE SPECIFICITY: Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle. PTM: At low cholesterol the SCAP/SREBP complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane. Apoptosis triggers cleavage by the cysteine proteases caspase-3 and caspase-7. PTM: Phosphorylated by AMPK, leading to suppress protein processing and nuclear translocation, and repress target gene expression. Phosphorylation at Ser-402 by SIK1 represses activity possibly by inhibiting DNA-binding (By similarity). SIMILARITY: Belongs to the SREBP family. SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain. SEQUENCE CAUTION: Sequence=AAB28522.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAD92846.1; Type=Miscellaneous discrepancy; Note=Intron retention; WEB RESOURCE: Name=Wikipedia; Note=Sterol regulatory element- binding protein entry; URL="http://en.wikipedia.org/wiki/Sterol_regulatory_element_binding_protein";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P36956
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003682 chromatin binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0005515 protein binding GO:0019901 protein kinase binding GO:0032810 sterol response element binding GO:0043565 sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding GO:0044877 macromolecular complex binding GO:0046983 protein dimerization activity
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0003062 regulation of heart rate by chemical signal GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0006629 lipid metabolic process GO:0007568 aging GO:0007623 circadian rhythm GO:0008202 steroid metabolic process GO:0008203 cholesterol metabolic process GO:0008286 insulin receptor signaling pathway GO:0008610 lipid biosynthetic process GO:0009267 cellular response to starvation GO:0009749 response to glucose GO:0010867 positive regulation of triglyceride biosynthetic process GO:0014070 response to organic cyclic compound GO:0019217 regulation of fatty acid metabolic process GO:0030324 lung development GO:0030522 intracellular receptor signaling pathway GO:0031065 positive regulation of histone deacetylation GO:0031647 regulation of protein stability GO:0032094 response to food GO:0032526 response to retinoic acid GO:0032570 response to progesterone GO:0032869 cellular response to insulin stimulus GO:0033762 response to glucagon GO:0033993 response to lipid GO:0042493 response to drug GO:0042789 mRNA transcription from RNA polymerase II promoter GO:0043434 response to peptide hormone GO:0045444 fat cell differentiation GO:0045540 regulation of cholesterol biosynthetic process GO:0045542 positive regulation of cholesterol biosynthetic process GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046676 negative regulation of insulin secretion GO:0050796 regulation of insulin secretion GO:0051591 response to cAMP GO:0070542 response to fatty acid GO:0071398 cellular response to fatty acid GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1903146 regulation of mitophagy GO:1903214 regulation of protein targeting to mitochondrion
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
