Human Gene SRGAP2 (ENST00000426388.1) from GENCODE V47lift37
  Description: SLIT-ROBO Rho GTPase activating protein 2 (from HGNC SRGAP2)
Gencode Transcript: ENST00000426388.1
Gencode Gene: ENSG00000163486.8
Transcript (Including UTRs)
   Position: hg19 chr1:206,623,784-206,632,264 Size: 8,481 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr1:206,623,784-206,632,264 Size: 8,481 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:206,623,784-206,632,264)mRNA (may differ from genome)Protein (226 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsHGNCMalacards
MGIPubMedUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: Q5VZB3_HUMAN
DESCRIPTION: SubName: Full=SLIT-ROBO Rho GTPase activating protein 2; Flags: Fragment;
SIMILARITY: Contains 1 SH3 domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SRGAP2
Diseases sorted by gene-association score: infantile epileptic encephalopathy (10), familial hypocalciuric hypercalcemia (5), 3p- syndrome (5), van der woude syndrome (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 88.54 RPKM in Brain - Cerebellum
Total median expression: 564.89 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001452 - SH3_domain

ModBase Predicted Comparative 3D Structure on Q5VZB3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK295845 - Homo sapiens cDNA FLJ60271 complete cds, highly similar to SLIT-ROBO Rho GTPase-activating protein 2.
AB463261 - Synthetic construct DNA, clone: pF1KA0456, Homo sapiens SRGAP2 gene for SLIT-ROBO Rho GTPase activating protein 2, without stop codon, in Flexi system.
BC132872 - Homo sapiens SLIT-ROBO Rho GTPase activating protein 2, mRNA (cDNA clone MGC:164503 IMAGE:40146894), complete cds.
BC132874 - Homo sapiens SLIT-ROBO Rho GTPase activating protein 2, mRNA (cDNA clone MGC:164505 IMAGE:40146896), complete cds.
BC144343 - Homo sapiens SLIT-ROBO Rho GTPase activating protein 2, mRNA (cDNA clone MGC:177880 IMAGE:9052863), complete cds.
AB007925 - Homo sapiens KIAA0456 mRNA for KIAA0456 protein.
KX533503 - Homo sapiens sLIT-ROBO Rho GTPase-activating protein 2 (SRGAP2) mRNA, complete cds.
AK293335 - Homo sapiens cDNA FLJ61210 complete cds, highly similar to SLIT-ROBO Rho GTPase-activating protein 2.
BC041635 - Homo sapiens SLIT-ROBO Rho GTPase activating protein 2, mRNA (cDNA clone IMAGE:4862729).
LF205337 - JP 2014500723-A/12840: Polycomb-Associated Non-Coding RNAs.
AK294060 - Homo sapiens cDNA FLJ56407 complete cds, highly similar to SLIT-ROBO Rho GTPase-activating protein 2.
AK000885 - Homo sapiens cDNA FLJ10023 fis, clone HEMBA1000608, highly similar to SLIT-ROBO Rho GTPase-activating protein 2.
AK057565 - Homo sapiens cDNA FLJ33003 fis, clone THYMU1000240.
LF319457 - JP 2014500723-A/126960: Polycomb-Associated Non-Coding RNAs.
AK311111 - Homo sapiens cDNA, FLJ18153.
LF319455 - JP 2014500723-A/126958: Polycomb-Associated Non-Coding RNAs.
LF319454 - JP 2014500723-A/126957: Polycomb-Associated Non-Coding RNAs.
MA440914 - JP 2018138019-A/12840: Polycomb-Associated Non-Coding RNAs.
MA555034 - JP 2018138019-A/126960: Polycomb-Associated Non-Coding RNAs.
MA555032 - JP 2018138019-A/126958: Polycomb-Associated Non-Coding RNAs.
MA555031 - JP 2018138019-A/126957: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: AK294060, Q5VZB3, Q5VZB3_HUMAN, RP11-421E17.2-005 , SRGAP2 , uc319vna.1
UCSC ID: ENST00000426388.1
RefSeq Accession: NM_001170637.4
Protein: Q5VZB3

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.