ID:SORCN_HUMAN DESCRIPTION: RecName: Full=Sorcin; AltName: Full=22 kDa protein; AltName: Full=CP-22; Short=CP22; AltName: Full=V19; FUNCTION: Calcium-binding protein that modulates excitation- contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. SUBUNIT: Homodimer. Interacts with GCA, RYR2 and ANXA7. INTERACTION: P40763:STAT3; NbExp=2; IntAct=EBI-750459, EBI-518675; SUBCELLULAR LOCATION: Cytoplasm. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels. TISSUE SPECIFICITY: Detected in cardiac myocytes. MISCELLANEOUS: This protein is encoded by an amplified gene in multidrug-resistant cells. MISCELLANEOUS: This protein has been shown to bind calcium with high affinity. SIMILARITY: Contains 4 EF-hand domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P30626
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0002020 protease binding GO:0004198 calcium-dependent cysteine-type endopeptidase activity GO:0005102 receptor binding GO:0005246 calcium channel regulator activity GO:0005509 calcium ion binding GO:0005515 protein binding GO:0042802 identical protein binding GO:0044325 ion channel binding GO:0046872 metal ion binding GO:0046982 protein heterodimerization activity GO:0070491 repressing transcription factor binding
Biological Process: GO:0001508 action potential GO:0006508 proteolysis GO:0006816 calcium ion transport GO:0006880 intracellular sequestering of iron ion GO:0006942 regulation of striated muscle contraction GO:0007165 signal transduction GO:0007507 heart development GO:0007517 muscle organ development GO:0008016 regulation of heart contraction GO:0010459 negative regulation of heart rate GO:0010649 regulation of cell communication by electrical coupling GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0042994 cytoplasmic sequestering of transcription factor GO:0051281 positive regulation of release of sequestered calcium ion into cytosol GO:0051924 regulation of calcium ion transport GO:0055118 negative regulation of cardiac muscle contraction GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0086004 regulation of cardiac muscle cell contraction GO:1901077 regulation of relaxation of muscle GO:1901841 regulation of high voltage-gated calcium channel activity GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction GO:2000678 negative regulation of transcription regulatory region DNA binding
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
