Human Gene SRP14 (ENST00000267884.11_7) from GENCODE V47lift37
  Description: signal recognition particle 14, transcript variant 1 (from RefSeq NM_003134.6)
Gencode Transcript: ENST00000267884.11_7
Gencode Gene: ENSG00000140319.11_9
Transcript (Including UTRs)
   Position: hg19 chr15:40,327,891-40,331,382 Size: 3,492 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr15:40,328,534-40,331,317 Size: 2,784 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:40,327,891-40,331,382)mRNA (may differ from genome)Protein (136 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SRP14_HUMAN
DESCRIPTION: RecName: Full=Signal recognition particle 14 kDa protein; Short=SRP14; AltName: Full=18 kDa Alu RNA-binding protein;
FUNCTION: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
SUBUNIT: Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.
SUBCELLULAR LOCATION: Cytoplasm.
SIMILARITY: Belongs to the SRP14 family.
WEB RESOURCE: Name=Wikipedia; Note=Signal recognition particle entry; URL="http://en.wikipedia.org/wiki/Signal_recognition_particle";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 127.03 RPKM in Pituitary
Total median expression: 4882.35 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -22.7065-0.349 Picture PostScript Text
3' UTR -141.30643-0.220 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003210 - Signal_recog_particle_SRP14
IPR009018 - Signal_recog_particle_SRP9/14

Pfam Domains:
PF02290 - Signal recognition particle 14kD protein

SCOP Domains:
54762 - Signal recognition particle alu RNA binding heterodimer, SRP9/14

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1E8O - X-ray MuPIT 1E8S - X-ray MuPIT 1RY1 - EM MuPIT


ModBase Predicted Comparative 3D Structure on P37108
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008312 7S RNA binding
GO:0030942 endoplasmic reticulum signal peptide binding

Biological Process:
GO:0006613 cotranslational protein targeting to membrane
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0042493 response to drug
GO:0043312 neutrophil degranulation
GO:0045047 protein targeting to ER

Cellular Component:
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005786 signal recognition particle, endoplasmic reticulum targeting
GO:0005829 cytosol
GO:0034774 secretory granule lumen
GO:0048500 signal recognition particle
GO:1904813 ficolin-1-rich granule lumen


-  Descriptions from all associated GenBank mRNAs
  BC100031 - Homo sapiens signal recognition particle 14kDa (homologous Alu RNA binding protein), mRNA (cDNA clone MGC:111680 IMAGE:2847600), complete cds.
BC071716 - Homo sapiens signal recognition particle 14kDa (homologous Alu RNA binding protein), mRNA (cDNA clone MGC:88011 IMAGE:4476669), complete cds.
BC035495 - Homo sapiens signal recognition particle 14kDa (homologous Alu RNA binding protein), mRNA (cDNA clone MGC:14326 IMAGE:4298087), complete cds.
BC051006 - Homo sapiens signal recognition particle 14kDa (homologous Alu RNA binding protein), mRNA (cDNA clone IMAGE:4577398), with apparent retained intron.
AB061546 - Homo sapiens SRP14 mRNA for signal recognition particle 14kD, complete cds.
X73459 - H.sapiens mRNA for signal recognition particle subunit 14.
U07857 - Human 18 kDa Alu RNA binding protein mRNA, complete cds.
U92988 - Homo sapiens clone DT1P1D2 mRNA, CAG repeat region.
JD427363 - Sequence 408387 from Patent EP1572962.
CU690086 - Synthetic construct Homo sapiens gateway clone IMAGE:100021873 5' read SRP14 mRNA.
HQ447734 - Synthetic construct Homo sapiens clone IMAGE:100071065; CCSB012462_01 signal recognition particle 14kDa (homologous Alu RNA binding protein) (SRP14) gene, encodes complete protein.
KJ892199 - Synthetic construct Homo sapiens clone ccsbBroadEn_01593 SRP14 gene, encodes complete protein.
AB451391 - Homo sapiens SRP14 mRNA for signal recognition particle 14 kDa protein, partial cds, clone: FLJ08081AAAF.
JD027126 - Sequence 8150 from Patent EP1572962.
JD027127 - Sequence 8151 from Patent EP1572962.
JD028346 - Sequence 9370 from Patent EP1572962.
JD033751 - Sequence 14775 from Patent EP1572962.
JD021078 - Sequence 2102 from Patent EP1572962.
JD021079 - Sequence 2103 from Patent EP1572962.
JD031740 - Sequence 12764 from Patent EP1572962.
JD036331 - Sequence 17355 from Patent EP1572962.
JD021607 - Sequence 2631 from Patent EP1572962.
JD024462 - Sequence 5486 from Patent EP1572962.
JD024587 - Sequence 5611 from Patent EP1572962.
JD030894 - Sequence 11918 from Patent EP1572962.
JD459567 - Sequence 440591 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P37108 (Reactome details) participates in the following event(s):

R-HSA-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)
R-HSA-1799326 Signal-containing nascent peptide translocates to endoplasmic reticulum
R-HSA-6800434 Exocytosis of ficolin-rich granule lumen proteins
R-HSA-6798748 Exocytosis of secretory granule lumen proteins
R-HSA-1799330 The SRP receptor binds the SRP:nascent peptide:ribosome complex
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-6798695 Neutrophil degranulation
R-HSA-72766 Translation
R-HSA-168249 Innate Immune System
R-HSA-392499 Metabolism of proteins
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: B5BUF5, ENST00000267884.1, ENST00000267884.10, ENST00000267884.2, ENST00000267884.3, ENST00000267884.4, ENST00000267884.5, ENST00000267884.6, ENST00000267884.7, ENST00000267884.8, ENST00000267884.9, NM_003134, P37108, Q6B0K5, Q96Q14, SRP14_HUMAN, uc317ilu.1, uc317ilu.2
UCSC ID: ENST00000267884.11_7
RefSeq Accession: NM_003134.6
Protein: P37108 (aka SRP14_HUMAN or SR14_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.