ID:SRP19_HUMAN DESCRIPTION: RecName: Full=Signal recognition particle 19 kDa protein; Short=SRP19; FUNCTION: Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP. SUBUNIT: Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the SRP19 family. WEB RESOURCE: Name=Wikipedia; Note=Signal recognition particle entry; URL="http://en.wikipedia.org/wiki/Signal-recognition_particle";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P09132
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006613 cotranslational protein targeting to membrane GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition GO:0042493 response to drug
AK311803 - Homo sapiens cDNA, FLJ92064, Homo sapiens signal recognition particle 19kDa (SRP19), mRNA. BC000186 - Homo sapiens, Similar to signal recognition particle 19kD, clone IMAGE:3352633, mRNA. X12791 - Human mRNA for 19kD protein of signal recognition particle (SRP). BC017830 - Homo sapiens signal recognition particle 19kDa, mRNA (cDNA clone MGC:22478 IMAGE:4252554), complete cds. AK313576 - Homo sapiens cDNA, FLJ94140, highly similar to Homo sapiens U2(RNU2) small nuclear RNA auxillary factor 1-like 1(U2AF1L1), mRNA. BC010947 - Homo sapiens signal recognition particle 19kDa, mRNA (cDNA clone MGC:13596 IMAGE:4285753), complete cds. BC018669 - Homo sapiens cDNA clone IMAGE:4249893, containing frame-shift errors. AB587423 - Synthetic construct DNA, clone: pF1KB6746, Homo sapiens SRP19 gene for signal recognition particle 19kDa, without stop codon, in Flexi system. JD422459 - Sequence 403483 from Patent EP1572962. JD409361 - Sequence 390385 from Patent EP1572962. JD202486 - Sequence 183510 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P09132 (Reactome details) participates in the following event(s):
R-HSA-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) R-HSA-1799326 Signal-containing nascent peptide translocates to endoplasmic reticulum R-HSA-1799330 The SRP receptor binds the SRP:nascent peptide:ribosome complex R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
