Human Gene SRRM2 (ENST00000301740.13_6) from GENCODE V47lift37
Description: serine/arginine repetitive matrix 2 (from RefSeq NM_016333.4)Gencode Transcript: ENST00000301740.13_6Gencode Gene: ENSG00000167978.19_14Transcript (Including UTRs) Position: hg19 chr16:2,802,639-2,821,413 Size: 18,775 Total Exon Count: 15 Strand: +Coding Region Position: hg19 chr16:2,806,366-2,820,868 Size: 14,503 Coding Exon Count: 14
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: SRRM2_HUMAN DESCRIPTION: RecName: Full=Serine/arginine repetitive matrix protein 2; AltName: Full=300 kDa nuclear matrix antigen; AltName: Full=Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa; Short=SR-related nuclear matrix protein of 300 kDa; Short=Ser/Arg-related nuclear matrix protein of 300 kDa; AltName: Full=Splicing coactivator subunit SRm300; AltName: Full=Tax-responsive enhancer element-binding protein 803; Short=TaxREB803;FUNCTION: Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). Binds to RNA.SUBUNIT: Component of the active spliceosome. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRP70, SNRPA1, SRRM1 and SRRM2. Identified in the spliceosome C complex.INTERACTION: Q16611:BAK1; NbExp=1; IntAct=EBI-1050142, EBI-519866; Q15287:RNPS1; NbExp=1; IntAct=EBI-1050142, EBI-395959; P31946:YWHAB; NbExp=1; IntAct=EBI-1050142, EBI-359815; P61981:YWHAG; NbExp=1; IntAct=EBI-1050142, EBI-359832;SUBCELLULAR LOCATION: Nucleus speckle.TISSUE SPECIFICITY: Expressed in liver, placenta, and white blood cells.PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.MISCELLANEOUS: Can functionally substitute for CWC12 in yeast (PubMed:19854871).SIMILARITY: Belongs to the CWC21 family.SEQUENCE CAUTION: Sequence=AAF21439.1; Type=Frameshift; Positions=Several; Sequence=AAF28898.1; Type=Frameshift; Positions=167, 175, 179; Sequence=AAH70050.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAA20782.3; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
C111118
2',3,3',4',5-pentachloro-4-hydroxybiphenyl
C016403
2,4-dinitrotoluene
C049584
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
C030370
2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone
D015123
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
D016604
Aflatoxin B1
D001564
Benzo(a)pyrene
D002737
Chloroprene
D002794
Choline
D002945
Cisplatin
D003375
Coumestrol
D004237
Diuron
D004958
Estradiol
D005492
Folic Acid
D005839
Gentamicins
D006861
Hydrogen Peroxide
D007657
Ketone Bodies
D008715
Methionine
D009151
Mustard Gas
D010634
Phenobarbital
D012643
Selenium
D013749
Tetrachlorodibenzodioxin
D013759
Tetrahydrocannabinol
D014810
Vitamin E
D024483
Vitamin K 3
C044887
beta-methylcholine
C018021
cobaltous chloride
C045950
propiconazole
C009277
sodium arsenate
C004648
testosterone enanthate
C025643
vinclozolin
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR013170 - mRNA_splic_Cwf21IPR024945 - Spt5_C_domPfam Domains: PF08312 - cwf21 domainModBase Predicted Comparative 3D Structure on Q9UQ35 The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
LF210718 - JP 2014500723-A/18221: Polycomb-Associated Non-Coding RNAs.BC070050 - Homo sapiens serine/arginine repetitive matrix 2, mRNA (cDNA clone IMAGE:30340453), partial cds.BC020639 - Homo sapiens serine/arginine repetitive matrix 2, mRNA (cDNA clone IMAGE:4733822), partial cds.AF201422 - Homo sapiens splicing coactivator subunit SRm300 (SRM300) mRNA, complete cds.JD462492 - Sequence 443516 from Patent EP1572962.AB016092 - Homo sapiens mRNA for RNA binding protein, complete cds.JD457302 - Sequence 438326 from Patent EP1572962.BC032416 - Homo sapiens serine/arginine repetitive matrix 2, mRNA (cDNA clone IMAGE:5215215), with apparent retained intron.BC046104 - Homo sapiens serine/arginine repetitive matrix 2, mRNA (cDNA clone IMAGE:6203679), partial cds.BC041155 - Homo sapiens serine/arginine repetitive matrix 2, mRNA (cDNA clone IMAGE:5576530), complete cds.BC007752 - Homo sapiens serine/arginine repetitive matrix 2, mRNA (cDNA clone IMAGE:4110278), partial cds.AB002322 - Homo sapiens KIAA0324 mRNA for KIAA0324 protein.AB016089 - Homo sapiens mRNA for RNA binding protein, partial cds, clone: R52.AB016088 - Homo sapiens mRNA for RNA binding protein, partial cds, clone: R11.LF340573 - JP 2014500723-A/148076: Polycomb-Associated Non-Coding RNAs.JD418418 - Sequence 399442 from Patent EP1572962.JD253331 - Sequence 234355 from Patent EP1572962.JD141726 - Sequence 122750 from Patent EP1572962.JD407390 - Sequence 388414 from Patent EP1572962.JD211399 - Sequence 192423 from Patent EP1572962.HM005593 - Homo sapiens clone HTL-S-53 testicular secretory protein Li 53 mRNA, complete cds.AB384460 - Synthetic construct DNA, clone: pF1KA0324, Homo sapiens SRRM2 gene for serine/arginine repetitive matrix protein 2, complete cds, without stop codon, in Flexi system.LF340590 - JP 2014500723-A/148093: Polycomb-Associated Non-Coding RNAs.BX647088 - Homo sapiens mRNA; cDNA DKFZp686O15166 (from clone DKFZp686O15166).LF340591 - JP 2014500723-A/148094: Polycomb-Associated Non-Coding RNAs.LF340600 - JP 2014500723-A/148103: Polycomb-Associated Non-Coding RNAs.AF161338 - Homo sapiens HSPC075 mRNA, partial cds.LF340601 - JP 2014500723-A/148104: Polycomb-Associated Non-Coding RNAs.LF340602 - JP 2014500723-A/148105: Polycomb-Associated Non-Coding RNAs.AB015644 - Homo sapiens mRNA for RNA binding protein, partial cds.AB016087 - Homo sapiens mRNA for RNA binding protein, partial cds, clone: R03.LF340603 - JP 2014500723-A/148106: Polycomb-Associated Non-Coding RNAs.BX537511 - Homo sapiens mRNA; cDNA DKFZp779C108 (from clone DKFZp779C108).LF340608 - JP 2014500723-A/148111: Polycomb-Associated Non-Coding RNAs.LF340611 - JP 2014500723-A/148114: Polycomb-Associated Non-Coding RNAs.LF340613 - JP 2014500723-A/148116: Polycomb-Associated Non-Coding RNAs.LF340616 - JP 2014500723-A/148119: Polycomb-Associated Non-Coding RNAs.LF340617 - JP 2014500723-A/148120: Polycomb-Associated Non-Coding RNAs.LF340619 - JP 2014500723-A/148122: Polycomb-Associated Non-Coding RNAs.LF340622 - JP 2014500723-A/148125: Polycomb-Associated Non-Coding RNAs.LF340623 - JP 2014500723-A/148126: Polycomb-Associated Non-Coding RNAs.LF340625 - JP 2014500723-A/148128: Polycomb-Associated Non-Coding RNAs.AB016090 - Homo sapiens mRNA for RNA binding protein, partial cds, clone: R83.LF340627 - JP 2014500723-A/148130: Polycomb-Associated Non-Coding RNAs.LF340630 - JP 2014500723-A/148133: Polycomb-Associated Non-Coding RNAs.LF340632 - JP 2014500723-A/148135: Polycomb-Associated Non-Coding RNAs.LF340634 - JP 2014500723-A/148137: Polycomb-Associated Non-Coding RNAs.LF340635 - JP 2014500723-A/148138: Polycomb-Associated Non-Coding RNAs.AB016091 - Homo sapiens mRNA for RNA binding protein, partial cds, clone: R86.LF340642 - JP 2014500723-A/148145: Polycomb-Associated Non-Coding RNAs.DQ589293 - Homo sapiens piRNA piR-56405, complete sequence.LF340643 - JP 2014500723-A/148146: Polycomb-Associated Non-Coding RNAs.LF340644 - JP 2014500723-A/148147: Polycomb-Associated Non-Coding RNAs.LF340645 - JP 2014500723-A/148148: Polycomb-Associated Non-Coding RNAs.LF340646 - JP 2014500723-A/148149: Polycomb-Associated Non-Coding RNAs.LF340648 - JP 2014500723-A/148151: Polycomb-Associated Non-Coding RNAs.LF340651 - JP 2014500723-A/148154: Polycomb-Associated Non-Coding RNAs.DQ570486 - Homo sapiens piRNA piR-30598, complete sequence.LF340653 - JP 2014500723-A/148156: Polycomb-Associated Non-Coding RNAs.BC028054 - Homo sapiens serine/arginine repetitive matrix 2, mRNA (cDNA clone IMAGE:4999979).BC107087 - Homo sapiens serine/arginine repetitive matrix 2, mRNA (cDNA clone IMAGE:40014497), partial cds.AK025579 - Homo sapiens cDNA: FLJ21926 fis, clone HEP04142, highly similar to AB016092 Homo sapiens mRNA for RNA binding protein.LF340655 - JP 2014500723-A/148158: Polycomb-Associated Non-Coding RNAs.DQ593798 - Homo sapiens piRNA piR-33910, complete sequence.LF340657 - JP 2014500723-A/148160: Polycomb-Associated Non-Coding RNAs.LF340659 - JP 2014500723-A/148162: Polycomb-Associated Non-Coding RNAs.LF340660 - JP 2014500723-A/148163: Polycomb-Associated Non-Coding RNAs.AK025903 - Homo sapiens cDNA: FLJ22250 fis, clone HRC02675, highly similar to AB016092 Homo sapiens mRNA for RNA binding protein.LF340662 - JP 2014500723-A/148165: Polycomb-Associated Non-Coding RNAs.LF340665 - JP 2014500723-A/148168: Polycomb-Associated Non-Coding RNAs.BC009062 - Homo sapiens, clone IMAGE:3875076, mRNA, partial cds.AL833672 - Homo sapiens mRNA; cDNA DKFZp667L0421 (from clone DKFZp667L0421).LF340669 - JP 2014500723-A/148172: Polycomb-Associated Non-Coding RNAs.LF340671 - JP 2014500723-A/148174: Polycomb-Associated Non-Coding RNAs.LF340673 - JP 2014500723-A/148176: Polycomb-Associated Non-Coding RNAs.LF340676 - JP 2014500723-A/148179: Polycomb-Associated Non-Coding RNAs.LF340677 - JP 2014500723-A/148180: Polycomb-Associated Non-Coding RNAs.JD262975 - Sequence 243999 from Patent EP1572962.JD096936 - Sequence 77960 from Patent EP1572962.JD387209 - Sequence 368233 from Patent EP1572962.JD498335 - Sequence 479359 from Patent EP1572962.JD521810 - Sequence 502834 from Patent EP1572962.LF340678 - JP 2014500723-A/148181: Polycomb-Associated Non-Coding RNAs.JD540983 - Sequence 522007 from Patent EP1572962.JD445774 - Sequence 426798 from Patent EP1572962.JD353774 - Sequence 334798 from Patent EP1572962.LF340680 - JP 2014500723-A/148183: Polycomb-Associated Non-Coding RNAs.JD471537 - Sequence 452561 from Patent EP1572962.JD239772 - Sequence 220796 from Patent EP1572962.JD447355 - Sequence 428379 from Patent EP1572962.LF340681 - JP 2014500723-A/148184: Polycomb-Associated Non-Coding RNAs.JD045629 - Sequence 26653 from Patent EP1572962.JD344831 - Sequence 325855 from Patent EP1572962.LF340682 - JP 2014500723-A/148185: Polycomb-Associated Non-Coding RNAs.MA446295 - JP 2018138019-A/18221: Polycomb-Associated Non-Coding RNAs.MA576150 - JP 2018138019-A/148076: Polycomb-Associated Non-Coding RNAs.MA576167 - JP 2018138019-A/148093: Polycomb-Associated Non-Coding RNAs.MA576168 - JP 2018138019-A/148094: Polycomb-Associated Non-Coding RNAs.MA576177 - JP 2018138019-A/148103: Polycomb-Associated Non-Coding RNAs.MA576178 - JP 2018138019-A/148104: Polycomb-Associated Non-Coding RNAs.MA576179 - JP 2018138019-A/148105: Polycomb-Associated Non-Coding RNAs.MA576180 - JP 2018138019-A/148106: Polycomb-Associated Non-Coding RNAs.MA576185 - JP 2018138019-A/148111: Polycomb-Associated Non-Coding RNAs.MA576188 - JP 2018138019-A/148114: Polycomb-Associated Non-Coding RNAs.MA576190 - JP 2018138019-A/148116: Polycomb-Associated Non-Coding RNAs.MA576193 - JP 2018138019-A/148119: Polycomb-Associated Non-Coding RNAs.MA576194 - JP 2018138019-A/148120: Polycomb-Associated Non-Coding RNAs.MA576196 - JP 2018138019-A/148122: Polycomb-Associated Non-Coding RNAs.MA576199 - JP 2018138019-A/148125: Polycomb-Associated Non-Coding RNAs.MA576200 - JP 2018138019-A/148126: Polycomb-Associated Non-Coding RNAs.MA576202 - JP 2018138019-A/148128: Polycomb-Associated Non-Coding RNAs.MA576204 - JP 2018138019-A/148130: Polycomb-Associated Non-Coding RNAs.MA576207 - JP 2018138019-A/148133: Polycomb-Associated Non-Coding RNAs.MA576209 - JP 2018138019-A/148135: Polycomb-Associated Non-Coding RNAs.MA576211 - JP 2018138019-A/148137: Polycomb-Associated Non-Coding RNAs.MA576212 - JP 2018138019-A/148138: Polycomb-Associated Non-Coding RNAs.MA576219 - JP 2018138019-A/148145: Polycomb-Associated Non-Coding RNAs.MA576220 - JP 2018138019-A/148146: Polycomb-Associated Non-Coding RNAs.MA576221 - JP 2018138019-A/148147: Polycomb-Associated Non-Coding RNAs.MA576222 - JP 2018138019-A/148148: Polycomb-Associated Non-Coding RNAs.MA576223 - JP 2018138019-A/148149: Polycomb-Associated Non-Coding RNAs.MA576225 - JP 2018138019-A/148151: Polycomb-Associated Non-Coding RNAs.MA576228 - JP 2018138019-A/148154: Polycomb-Associated Non-Coding RNAs.MA576230 - JP 2018138019-A/148156: Polycomb-Associated Non-Coding RNAs.MA576232 - JP 2018138019-A/148158: Polycomb-Associated Non-Coding RNAs.MA576234 - JP 2018138019-A/148160: Polycomb-Associated Non-Coding RNAs.MA576236 - JP 2018138019-A/148162: Polycomb-Associated Non-Coding RNAs.MA576237 - JP 2018138019-A/148163: Polycomb-Associated Non-Coding RNAs.MA576239 - JP 2018138019-A/148165: Polycomb-Associated Non-Coding RNAs.MA576242 - JP 2018138019-A/148168: Polycomb-Associated Non-Coding RNAs.MA576246 - JP 2018138019-A/148172: Polycomb-Associated Non-Coding RNAs.MA576248 - JP 2018138019-A/148174: Polycomb-Associated Non-Coding RNAs.MA576250 - JP 2018138019-A/148176: Polycomb-Associated Non-Coding RNAs.MA576253 - JP 2018138019-A/148179: Polycomb-Associated Non-Coding RNAs.MA576254 - JP 2018138019-A/148180: Polycomb-Associated Non-Coding RNAs.MA576255 - JP 2018138019-A/148181: Polycomb-Associated Non-Coding RNAs.MA576257 - JP 2018138019-A/148183: Polycomb-Associated Non-Coding RNAs.MA576258 - JP 2018138019-A/148184: Polycomb-Associated Non-Coding RNAs.MA576259 - JP 2018138019-A/148185: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: A6NKB9, D3DU97, ENST00000301740.1, ENST00000301740.10, ENST00000301740.11, ENST00000301740.12, ENST00000301740.2, ENST00000301740.3, ENST00000301740.4, ENST00000301740.5, ENST00000301740.6, ENST00000301740.7, ENST00000301740.8, ENST00000301740.9, HSPC075, KIAA0324, NM_016333, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ35, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40, SRL300, SRM300, SRRM2_HUMAN, uc317mwl.1, uc317mwl.2UCSC ID: ENST00000301740.13_6RefSeq Accession: NM_016333.4 Protein: Q9UQ35
(aka SRRM2_HUMAN)
Gene Model Information
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for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
