ID:SRSF7_HUMAN DESCRIPTION: RecName: Full=Serine/arginine-rich splicing factor 7; AltName: Full=Splicing factor 9G8; AltName: Full=Splicing factor, arginine/serine-rich 7; FUNCTION: Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. SUBUNIT: Found in large molecular weight complexes containing CCNL1 and the p110 isoforms of either CDC2L1 or CDC2L2. Interacts with CCNL2 and CPSF6. INTERACTION: Q7Z6E9:RBBP6; NbExp=3; IntAct=EBI-398885, EBI-2117026; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Brain, liver, kidney and lung. PTM: Extensively phosphorylated on serine residues in the RS domain. SIMILARITY: Belongs to the splicing factor SR family. SIMILARITY: Contains 1 CCHC-type zinc finger. SIMILARITY: Contains 1 RRM (RNA recognition motif) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q16629
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC022328 - Homo sapiens splicing factor, arginine/serine-rich 7, 35kDa, mRNA (cDNA clone MGC:22746 IMAGE:4251314), complete cds. AK091425 - Homo sapiens cDNA FLJ34106 fis, clone FCBBF3008073, highly similar to SPLICING FACTOR, ARGININE/SERINE-RICH 7. AX746975 - Sequence 500 from Patent EP1308459. AY513287 - Homo sapiens aging-associated protein 3 (AAG3) mRNA, complete cds. JD129715 - Sequence 110739 from Patent EP1572962. AK225141 - Homo sapiens mRNA for splicing factor, arginine/serine-rich 7, 35kDa isoform 1 variant, clone: CBL09471. JD247951 - Sequence 228975 from Patent EP1572962. JD524272 - Sequence 505296 from Patent EP1572962. JD295507 - Sequence 276531 from Patent EP1572962. JD056024 - Sequence 37048 from Patent EP1572962. AK293667 - Homo sapiens cDNA FLJ59182 complete cds, highly similar to Splicing factor, arginine/serine-rich 7. JD432291 - Sequence 413315 from Patent EP1572962. AK297161 - Homo sapiens cDNA FLJ60677 complete cds, highly similar to Splicing factor, arginine/serine-rich 7. AF055270 - Homo sapiens heat-shock suppressed protein 1 (HSSG1) mRNA, complete cds. BC000997 - Homo sapiens splicing factor, arginine/serine-rich 7, 35kDa, mRNA (cDNA clone MGC:5238 IMAGE:2901284), complete cds. BC017369 - Homo sapiens splicing factor, arginine/serine-rich 7, 35kDa, mRNA (cDNA clone MGC:1320 IMAGE:2967417), complete cds. AY166860 - Homo sapiens arginine/serine-rich splicing factor 7 type B mRNA, complete cds. AK094126 - Homo sapiens cDNA FLJ36807 fis, clone ASTRO2000141. BC017908 - Homo sapiens splicing factor, arginine/serine-rich 7, 35kDa, mRNA (cDNA clone MGC:23824 IMAGE:4276642), complete cds. JD240684 - Sequence 221708 from Patent EP1572962. L22253 - Homo sapiens 9G8 splicing factor mRNA, complete cds. AB445102 - Homo sapiens 9g8 mRNA for splicing factor, arginine/serine-rich 7, complete cds. KJ892131 - Synthetic construct Homo sapiens clone ccsbBroadEn_01525 SRSF7 gene, encodes complete protein. BT006745 - Homo sapiens splicing factor, arginine/serine-rich 7, 35kDa mRNA, complete cds. AB527733 - Synthetic construct DNA, clone: pF1KB6956, Homo sapiens SFRS7 gene for splicing factor, arginine/serine-rich 7, 35kDa, without stop codon, in Flexi system. JD304018 - Sequence 285042 from Patent EP1572962. JD289363 - Sequence 270387 from Patent EP1572962. JD507711 - Sequence 488735 from Patent EP1572962. JD170675 - Sequence 151699 from Patent EP1572962. JD246633 - Sequence 227657 from Patent EP1572962. JD487972 - Sequence 468996 from Patent EP1572962. JD278287 - Sequence 259311 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q16629 (Reactome details) participates in the following event(s):
R-HSA-72107 Formation of the Spliceosomal E complex R-HSA-75080 Formation of AT-AC A complex R-HSA-75096 Docking of the TAP:EJC Complex with the NPC R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-8849157 TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally R-HSA-72185 mRNA polyadenylation R-HSA-72180 Cleavage of mRNA at the 3'-end R-HSA-75081 Formation of AT-AC B Complex R-HSA-75082 ATAC spliceosome mediated Lariat formation,5' splice site cleavage R-HSA-75079 Formation of AT-AC C complex R-HSA-75083 ATAC spliceosome mediated 3' splice site cleavage, exon ligation R-HSA-156661 Formation of Exon Junction Complex R-HSA-159101 NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72165 mRNA Splicing - Minor Pathway R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72187 mRNA 3'-end processing R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-72172 mRNA Splicing R-HSA-72202 Transport of Mature Transcript to Cytoplasm R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-73856 RNA Polymerase II Transcription Termination R-HSA-8953854 Metabolism of RNA R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
