ID:SRSF9_HUMAN DESCRIPTION: RecName: Full=Serine/arginine-rich splicing factor 9; AltName: Full=Pre-mRNA-splicing factor SRp30C; AltName: Full=Splicing factor, arginine/serine-rich 9; FUNCTION: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10. SUBUNIT: Interacts with KHDRBS3 (By similarity). Interacts with NOL3/ARC/NOP30, NSEP1/YB-1/YB1, SAFB/SAFB1, SRSF6/SFRS6 and TRA2B/SFRS10. May also interact with DUSP11/PIR1. SUBCELLULAR LOCATION: Nucleus. Note=Cellular stresses such as heat shock may induce localization to discrete nuclear bodies termed SAM68 nuclear bodies (SNBs), HAP bodies, or stress bodies. Numerous splicing factors including SRSF1/SFRS1/SF2, SRSF7/SFRS7, SAFB and KHDRBS1/SAM68 accumulate at these structures, which may participate in the post-transcriptional regulation of mRNAs in stressed cells. TISSUE SPECIFICITY: Expressed at high levels in the heart, kidney, pancreas and placenta, and at lower levels in the brain, liver, lung and skeletal muscle. PTM: Extensively phosphorylated on serine residues in the RS domain (By similarity). SIMILARITY: Belongs to the splicing factor SR family. SIMILARITY: Contains 2 RRM (RNA recognition motif) domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13242
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
U30825 - Human splicing factor SRp30c mRNA, complete cds. JD331717 - Sequence 312741 from Patent EP1572962. AK290644 - Homo sapiens cDNA FLJ76387 complete cds, highly similar to Homo sapiens splicing factor, arginine/serine-rich 9 (SFRS9), mRNA. BC093971 - Homo sapiens splicing factor, arginine/serine-rich 9, mRNA (cDNA clone MGC:121006 IMAGE:7939816), complete cds. BC093973 - Homo sapiens splicing factor, arginine/serine-rich 9, mRNA (cDNA clone MGC:121008 IMAGE:7939818), complete cds. JD418630 - Sequence 399654 from Patent EP1572962. KJ892596 - Synthetic construct Homo sapiens clone ccsbBroadEn_01990 SRSF9 gene, encodes complete protein. AB528895 - Synthetic construct DNA, clone: pF1KE0653, Homo sapiens SFRS9 gene for splicing factor, arginine/serine-rich 9, without stop codon, in Flexi system. AK294254 - Homo sapiens cDNA FLJ56571 complete cds, highly similar to Splicing factor, arginine/serine-rich 9. AK309778 - Homo sapiens cDNA, FLJ99819.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q13242 (Reactome details) participates in the following event(s):
R-HSA-72107 Formation of the Spliceosomal E complex R-HSA-75096 Docking of the TAP:EJC Complex with the NPC R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-8849157 TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally R-HSA-72185 mRNA polyadenylation R-HSA-72180 Cleavage of mRNA at the 3'-end R-HSA-156661 Formation of Exon Junction Complex R-HSA-159101 NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72187 mRNA 3'-end processing R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-72172 mRNA Splicing R-HSA-72202 Transport of Mature Transcript to Cytoplasm R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-73856 RNA Polymerase II Transcription Termination R-HSA-8953854 Metabolism of RNA R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
