The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
SCOP Domains: 88946 - Sigma2 domain of RNA polymerase sigma factors 46589 - tRNA-binding arm 47220 - alpha-catenin/vinculin-like 46966 - Spectrin repeat 52540 - P-loop containing nucleoside triphosphate hydrolases 90257 - Myosin rod fragments 58010 - Fibrinogen coiled-coil and central regions 58104 - Methyl-accepting chemotaxis protein (MCP) signaling domain
ModBase Predicted Comparative 3D Structure on O43805
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC000864 - Homo sapiens Sjogren syndrome nuclear autoantigen 1, mRNA (cDNA clone MGC:5078 IMAGE:3459939), complete cds. BC004118 - Homo sapiens Sjogren's syndrome nuclear autoantigen 1, mRNA (cDNA clone IMAGE:3843148), partial cds. Z96932 - Homo sapiens mRNA for NA14 protein. KJ892581 - Synthetic construct Homo sapiens clone ccsbBroadEn_01975 SSNA1 gene, encodes complete protein. CR542238 - Homo sapiens full open reading frame cDNA clone RZPDo834E1025D for gene SSNA1, Sjogren's syndrome nuclear autoantigen 1; complete cds, without stopcodon. BT006766 - Homo sapiens Sjogren's syndrome nuclear autoantigen 1 mRNA, complete cds. BC015827 - Homo sapiens Sjogren's syndrome nuclear autoantigen 1, mRNA (cDNA clone IMAGE:3634494), partial cds. DQ583563 - Homo sapiens piRNA piR-50675, complete sequence. JD402331 - Sequence 383355 from Patent EP1572962. JD271223 - Sequence 252247 from Patent EP1572962. JD487708 - Sequence 468732 from Patent EP1572962. JD373973 - Sequence 354997 from Patent EP1572962. JD484673 - Sequence 465697 from Patent EP1572962. JD414284 - Sequence 395308 from Patent EP1572962. JD384136 - Sequence 365160 from Patent EP1572962. JD500754 - Sequence 481778 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O43805 (Reactome details) participates in the following event(s):
R-HSA-380272 Plk1-mediated phosphorylation of Nlp R-HSA-380283 Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome R-HSA-380294 Loss of C-Nap-1 from centrosomes R-HSA-380311 Recruitment of Plk1 to centrosomes R-HSA-380455 Recruitment of CDK11p58 to the centrosomes R-HSA-380303 Dissociation of Phospho-Nlp from the centrosome R-HSA-5626220 C2CD3 binds the mother centriole R-HSA-380508 Translocation of NuMA to the centrosomes R-HSA-2574845 AJUBA binds centrosome-associated AURKA R-HSA-8853405 TPX2 binds AURKA at centrosomes R-HSA-3000319 BORA binds PLK1 and AURKA R-HSA-2574840 AJUBA facilitates AURKA autophosphorylation R-HSA-3000310 AURKA phosphorylates PLK1 R-HSA-5626223 C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole R-HSA-5626681 Recruitment of transition zone proteins R-HSA-5626227 CP110 and CEP97 dissociate from the centriole R-HSA-380316 Association of NuMA with microtubules R-HSA-8853419 TPX2 promotes AURKA autophosphorylation R-HSA-5626228 The distal appendage proteins recruit TTBK2 R-HSA-5638009 CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body R-HSA-5626699 MARK4 binds ODF2 in the centriole R-HSA-5617816 RAB3IP stimulates nucleotide exchange on RAB8A R-HSA-380259 Loss of Nlp from mitotic centrosomes R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-5620912 Anchoring of the basal body to the plasma membrane R-HSA-380320 Recruitment of NuMA to mitotic centrosomes R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-8854518 AURKA Activation by TPX2 R-HSA-380287 Centrosome maturation R-HSA-5617833 Cilium Assembly R-HSA-68877 Mitotic Prometaphase R-HSA-69275 G2/M Transition R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-68886 M Phase R-HSA-453274 Mitotic G2-G2/M phases R-HSA-69278 Cell Cycle (Mitotic) R-HSA-1640170 Cell Cycle
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
